[1]唐波,郑磊,李前伟.血管活性肠肽受体显像及治疗研究进展[J].国际放射医学核医学杂志,2011,35(4):212-216.[doi:10.3760/cma.j.issn.1673-4114.2011.04.004]
 TANG Bo,ZHENG Lei,LI Qian-wei.Advances on the imaging and therapy of vasoactive intestinal peptide receptor[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(4):212-216.[doi:10.3760/cma.j.issn.1673-4114.2011.04.004]
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血管活性肠肽受体显像及治疗研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第4期
页码:
212-216
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Advances on the imaging and therapy of vasoactive intestinal peptide receptor
作者:
唐波 郑磊 李前伟
第三军医大学西南医院核医学科, 重庆 400038
Author(s):
TANG Bo ZHENG Lei LI Qian-wei
Department of Nuclear Medicine, Southwest Hospital of the Third Military Medical Universiiy, Chongqing 400038, China
关键词:
受体血管活性肠肽放射性核素显像放射疗法
Keywords:
Receptorsvasoactive intestinal peptideRadionuclide imagingRadiotherapy
DOI:
10.3760/cma.j.issn.1673-4114.2011.04.004
摘要:
血管活性肠肽(VIP)是由28个氨基酸组成的小分子多肽,属胰高血糖素-胰泌素家族,通过其受体(VIPR)介导,调节正常及肿瘤细胞的增殖与分化。多种类型的肿瘤细胞膜上表达高密度及高亲和力VIPR,为实现肿瘤放射性核素标记VIPR显像及靶向治疗提供了分子基础。新的VIPR放射性配体的研发极大地推动了肿瘤VIPR显像及治疗的研究,有望在肿瘤的早期诊断、分期及靶向治疗中发挥重要作用。
Abstract:
Vasoactive intestinal peptide(VIP) is a peptide hormone containing 28 amino acid residues, and it belongs to glucagon-secretin family. VIP regulates the proliferation and differentiation of normal and cancer cell through the mediation of vasoactive intestinal peptide receptor(VIPR). Different types of cancer cell membrane express distinct density and affinity of VIPR, which provides the underlying molecular basis for labeling VIPR for radionuclide imaging and targeted therapy. The progress of VIPR radioligand research greatly promotes tumor VIPR imaging and therapy. The research will play an important part in the early diagnosis, staging, and targeted therapy of cancer.

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备注/Memo

备注/Memo:
收稿日期:2011-03-07。
通讯作者:李前伟(Email:tmmuxnyy@yahoo.com.cn)
更新日期/Last Update: 1900-01-01