[1]覃春霞,兰晓莉,张永学.多模式分子影像PET-MRI的研究进展[J].国际放射医学核医学杂志,2011,35(4):207-212.[doi:10.3760/cma.j.issn.1673-4114.2011.04.003]
 QIN Chun-xia,LAN Xiao-li,ZHANG Yong-xue.Progress in PET-MRI multimodality molecular imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(4):207-212.[doi:10.3760/cma.j.issn.1673-4114.2011.04.003]
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多模式分子影像PET-MRI的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第4期
页码:
207-212
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Progress in PET-MRI multimodality molecular imaging
作者:
覃春霞 兰晓莉 张永学
华中科技大学同济医学院附属协和医院核医学科, 湖北省分子影像重点实验室, 武汉 430022
Author(s):
QIN Chun-xia LAN Xiao-li ZHANG Yong-xue
Department of Nuclear Medicine and PET Center, Union Hospital, Tongji Medical College, Huazlwng University of Science and Technology, Molecular Imaging Key Laboratory of Hubei Province, Wuhan 430022, China
关键词:
正电子发射断层显像术磁共振成像分子影像技术
Keywords:
Positron-emission tomographyMagnetic resonance imagingMolecular imaging techniques
DOI:
10.3760/cma.j.issn.1673-4114.2011.04.003
摘要:
PET-CT已成为当今恶性肿瘤诊断、分期及疗效评价必不可少的工具,但是,MRI具有比CT更好的软组织分辨力,还可提供多种生理功能、多序列和多参数成像,且无放射性损伤,其与PET提供的分子信息互补、融合,有望成为新的双模式显像工具,在基础和临床研究中将起着至关重要的作用。然而PET与MRI结合在技术上具有很多挑战,近几年来成为分子影像学研究的热点,并已取得了重大进展。该文对PET-MRI融合技术及设备、初步应用及多模式探针的研究进展等作相关综述。
Abstract:
PET-CT multimodality imaging has become an essential tool for diagnosis, staging and therapeutic evaluation for malignancy. But MRI has better soft tissue resolution than CT, and provides a variety of functional imaging, multi-sequence and multi-parameter imaging, and has no radiation damage. The integration of plentiful information from MRI and molecular information provided by PET is expected to become a new dual-mode imaging tool which will play a very important role in basic and clinical research. However, many challenges are existed in the combined PET and MRI technology, and it has become a focus in molecular imaging research in recent years, and has made significant progress. This paper overviews the progresses of PET-MRI integration technologies and devices, preliminary applications and multi modality probes.

参考文献/References:

[1] Pichler BJ,Wehrl HF,Judenhofer MS.Latest advances in molecular imaging instrumentation.J Nucl Med,2008,49(Suppl 2):5S-23S.
[2] Antoch G,Bockisch A.Combined FET/MRI:a new dimension in whole-body oncology imaging?.Eur J Nucl Med Mol Imaging,2009,36(Suppl 1):S113-S120.
[3] Bolus NE,George R,Washington J,et al.PET/MRI:the blended-modality choice of the future?.J Nucl Med Technol,2009,37(2):63-71.
[4] Wehrl HF,Judenhofer MS,Wiehr S,et al.Pre-clinical PET/MR:technological advances and new perspectives in biomedical research.Eur J Nucl Med Mol Imaging,2009,36(Suppl 1):S56-S68,
[5] Delso G,Ziegler S.PET/MRI system design.Eur J Nucl Med Mol Imaging,2009,36(Suppl 1):S86-S92.
[6] Sauter AW,Wehrl HF,Kolb A,et al.Combined PET/M RI:one step further in multimodality imaging.Trends Mol Med,2010,16(11):508-515.
[7] Shao Y,Cherry S R,Farahani K,et al.Development of a PET detector system compatible with MRI/NMR systems.IEEE Trans Nucl Sci,1997,44(3):1167-1171.
[8] Marsden PK,Strul D,Keevil SF,et al.Simultaneous PET and NMR.Br J Radiol 2002,75(Suppl 9):S53-S59.
[9] Pichler BJ,Swann BK,Rochelle J,et al.Lutetium oxyorthosilicate block detector readout by avalanche photodiode arrays for high resolution animal PET.Phys Med Biol,2004,49(18):4305-4319.
[10] Martinez-Möller A,Souvatzoglou M,Delso G,et al.Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI:evaluation with PKT/CT data.J Nucl Med,2009,50(4):520-526.
[11] Judenhofer MS,Wehrl HF,Newport DF,et al.Simultaneous PET-MRI:a new approach for functional and morphological imaging.Nat Med,2008,14(4):459-465.
[12] Catana C,Procissi D,Wu Y,et al.Simultaneous in vivo positron emission tomography and magnetic resonance imaging.Proc Natl Acad Sci USA,2008,105(10):3705-3710.
[13] Schlemmer HP,Pichler BJ,Krieg R,et al.An integrated MR/PET system:prospective applications.Abdom Imaging,2009,34(6):668-674.
[14] Schlemmer HP,Pichler BJ,Schmand M,et al.Simultaneous MR/PET imaging of the human brain:feasibility study.Radiology,2008,248(3):1028-1035.
[15] Schlemmer HP,Pichler B,Wienhard K,et al.Simultaneous MR/PET for brain imaging:first patient scans,J Nucl Med,2007,48(Suppl 2):45P.
[16] Boss A,Kolb A,Hofmann M,et al.Diffusion tensor imaging in a human PET/MR hybrid system.Invest Radiol,2010,45(5):270-274.[17] Lucas AJ,Hawkes RC,Ansorge RE,et al.Development of a combined micro PET-MR system.Technol Cancer Res Treat,2006,5(4):337-341
[18] Yamamoto S,Imaizumi M,Kanai Y,et al.Design and performance from an integrated PET/MRI system for small animals.Ann Nucl Med,2010,24(2):89-98.
[19] Handler W,Chronik B,Scholl T,et al.Combining field-cycled magnetic resonance imaging with positron emission tomography.J Nucl Med,2007,48(Suppl 2):89p.
[20] Gilbert KM,Handler WB,Scholl TJ,et al.Design of field-cycled magnetic resonance systems for small animal imaging.Phys Med Biol,2006,51(11):2825-2841.
[21] Hofmann M,Steinke F,Scheel V,et al.MRI-based attenuation correction for PET/MRI:a novel approach combining pattern recognition and atlas registration.J Nucl Med,2008,49(11):1875-1883.
[22] Keereman V,Fierens Y,Broux T,et al.MRI-based attenuation correction for PET/MRI using ultrashort echo time sequences.J Nucl Med,2010,51(5):812-818.
[23] Schulz V,Torres-Espallardo I,Renisch S,et al.Automatic,three-segment,MK-based attenuation correction for whole-body PET/MR data.Eur J Nucl Med Mol Imaging,2011,38(1):138-152.
[24] Salomon A,Coedicke A,Schweizer B,et al.Simultaneous reconstruction of activity and attenuation for PKT/MR.IEEE Trans Med Imaging,2011,30(3):804-813.
[25] Hofmann M,Pichler B,Schölkopf B,et al.Towards quantitative PET/M RI:a review of MR-based attenuation correction techniques.Eur J Nucl Med Mol Imaging,2009,36(Suppl 1):S93-S104.
[26] Thesen S,Heid O,Mueller E,et al.Prospective acquisition correction for head motion with image-based tracking for real-time fMRI.Magn Reson Med,2000,44(3):457-465.
[27] Catana C,Benner T,van der Kouwe A,et al.MRI-assisted PET motion correction for neurologic studies in an integrated MR-PET scanner.J Nucl Med,2011,52(1):154-161.
[28] Cho ZH,Son YD,Kim HK,et al.A fusion PET-MRI system with a high-resolution research tomograph-PET and ultra-high field 7.0 T-MRI for the molecular-genetic imaging of the brain.Proteomics,2008,8(6):1302-1323.
[29] Cho ZH,Son YD,Kim HK,et al.Substructural hippocampal glucose metabolism observed on PET/MRI.J Nucl Med,2010,51(10):1545-1548.
[30] Cho ZH,Son YD,Kim HK,et al.Horizontal versus longitudinal axis of the hippocampus:metabolic differentiation as measured with high-resolution PET/MRI.J Nucl Med,2011,[Epuh ahead of print].
[31] Cho ZH, Son YD,Kim HK,et al.Observation of glucose metabolism in the thalamic nuclei by fusion PET/MRI.J Nurl Med,2011,52(3):401-404.
[32] Thor warth D,Hülle G,Mailer AC,et al.Simultaneous(68)Ga-DOTATOC-FKT/MRI for IMRT treatment planning for meningioma:first experience.Int J Radiat Oncol Biol Phys,2011,81(1):277-283.
[33] Chapon C,Jackson JS,Aboagye EO,et al. An in vivo multimodal imaging study using MRI and PET of stem cell transplantation after myocardial infarction in rats.Mol Imaging Biol,2009.11(1):31-38.
[34] Cicearelli O,Catani M,Johansen-Berg H,et al.Diffusion-based tractography in neurological disorders:concepts applications,and future developments.Lancet Neurol,2008,7(8):715-727.
[35] Büscher K,Judenhofer MS,Kuhlmann MT,et al.Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRL.J Nucl Med,2010,51(8):1277-1284.
[36] Nekolla SG,Martinez-Moeller A,Saraste A.PET and MRI in cardiac imaging:from validation studies to integrated applications.EurJ Nucl Med Mol Imaging,2009,36(Suppl 1):S121-S130.
[37] Daftary A.PET-MRI:challenges and new directions.Indian J Nucl Med,2010,25(1):3-5.
[38] Van Goethem M,Tjalma W,Schelfout K,et al.Magnetic resonance imaging in breast cancer.Eur J Surg Oncol,2006,32(9):901-910.
[39] Bao A,Coins B,Dodd GD 3rd,et al.Real-time iterative monitoring of radiofrequency ablation tumor therapy with 150-water PET imaging.J Nucl Med,2008,49(10):1723-1729.
[40] Lee S,Chen X.Dual-modality probes for in vivo molecular imaging.Mol Imaging,2009,8(2):87-100.
[41] Lee HY,Li Z,Chen K,et al.PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic(RGD)-conjugated radiolabeled iron oxide nanoparticles.J Nucl Med,2008,49(8):1371-1379.
[42] Xie J,Huang J,Li X,et al.Iron oxide nanoparticle platform for biomedical applications.Curr Med Chem,2009,16(10):1278-1294.
[43] Cheon J,Lee JH.Synergistically integrated nanoparticles as multimodal probes for nanobiotechnology.Acc Chem Res,2008,41(12):1630-1640.
[44] Shokeen M,Fettig NM,Rossin R.Synthesis,in vitro and in vivo evaluation of radiolabeled nanoparticles.Q J Nucl Med Mol Imaging,2008,52(3):267-277.
[45] Claus C,Rossin R,Welch MJ,et al.In vivo evaluation of (64)Cu-labeled magnetic nanoparticles as a dual-modality PET/MR imaging agent.Bioconjug Chem,2010,21(4):715-722.
[46] Patel D,Kell A,Simard B,et al.The cell labeling efficacy,cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents.Biomaterials,2011,32(4):1167-1176.
[47] Xie J,Chen K,Huang J,et al.PET/NIRF/MRI triple functional iron oxide nanoparticles.Biomaterials,2010,31(11):3016-3022.
[48] Park JC,Yu M K,An GI,et al.Facile preparation of a hybrid nanoprobe for triple-modality optical/PET/MR imaging.Small,2010,6(24):2863-2868.
[49] Stelter L,Pinkernelle JG,Michel R,et al.Modification of aminosi-lanized superparamagnetic nanoparticles:feasibility of multimodal detection using 3T MRI,small animal PET,and fluorescence imaging.Mol Imaging Biol,2010,12(1):25-34.
[50] Higuchi T,Anton M,Dumler K,et al.Combined reporter gene PET and iron oxide MRI for monitoring survival and localization of transplanted cells in the rat heart.J Nucl Med,2009,50(7):1088-1094.
[51] Uppal R,Catana C,Ay I.et al.Bimodal thrombus imaging:simultaneous PET/MR imaging with a fibrin-targeted dual PET/MRP robe-feasibility study in rat model.Radiology,2011,258(3):812-820.

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备注/Memo

备注/Memo:
收稿日期:2011-05-19。
基金项目:国家自然科学基金(81071200;30830041)
通讯作者:张水学(Email:zhyxl229@163.com)
更新日期/Last Update: 1900-01-01