[1]赵修义,邵亚辉,汪延明,等.亲属活体肾供者肾小球滤过率与年龄的相关性及其临床意义[J].国际放射医学核医学杂志,2010,34(5):277-281.[doi:10.3760/cma.j.issn.1673-4114.2010.05.006]
　ZHAO Xiu-yi,SHAO Ya-hui,WANG Yan-ming,et al.Correlation and clinical significance between glomerular filtration rate and age in living-related kidney donors[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(5):277-281.[doi:10.3760/cma.j.issn.1673-4114.2010.05.006]
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亲属活体肾供者肾小球滤过率与年龄的相关性及其临床意义(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第5期
页码:
277-281
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Correlation and clinical significance between glomerular filtration rate and age in living-related kidney donors
作者:
赵修义1;  邵亚辉1;  汪延明1;  张爱民2;  郝俊文2;  田军1;  孙奔1;  韩建奎3
1. 250031, 济南军区总医院核医学科;
2. 250031, 济南军区总医院泌尿外科;
3. 250012, 济南, 山东大学齐鲁医院核医学科
Author(s):
ZHAO Xiu-yi1;  SHAO Ya-hui1;  WANG Yan-ming1;  ZHANG Ai-min2;  HAO Jun-wen2;  TIAN Jun1;  SUN Ben1;  HAN Jian-kui3
Department of Nuclear Medicine, Jinan Military General Hospital, Jinan 250031, China
关键词:
肾移植; 肾小球滤过率; 活体供者; 核型家庭
Keywords:
Kidney transplantation; Glomerular filtration rate; Livingdonors; Nuclear family
DOI:
10.3760/cma.j.issn.1673-4114.2010.05.006
摘要:
目的 探讨亲属活体肾供者肾小球滤过率(GFR)与年龄的相关性及其临床意义,为活体肾供者的选择提供客观的依据。方法 161名亲属活体肾供者按年龄分为4组:第1组20~29岁(n=52),第2组30~39岁(n=44),第3组40~49岁(n=38),第4组≥50岁(n=27);同时以55岁为界,分为老年供肾组(>55岁,n=24)和中青年供肾组(≤55岁,n=137)。利用99Tcm-二亚乙基三胺五乙酸肾动态显像法定量测量供肾者GFR,对比分析不同年龄组间GFR的特性。结果 亲属活体供肾者双肾GFR为(89.55±12.87) ml·min-1·(1.73 m2)-1,不同年龄组(1~4组) GFR分别为:(88.27±12.29) ml·min-1·(1.73 m2)-1、(91.85±14.51) ml·min-1·(1.73 m2)-1、(89.25±11.26) ml·min-1·(1.73 m2)-1和(88.24±13.20) ml·min-1·(1.73 m2)-1,各组间GFR差异无统计学意义(F=2.09,P=0.10);老年供肾组与中青年供肾组GFR分别为(88.57±13.14) ml·min-1·(1.73 m2)-1、(89.44±10.34) ml·min-1·(1.73 m2)-1,两组间GFR差异无统计学意义(F=1.31,P=0.25)。经相关性分析,亲属供肾者GFR与年龄变化无明显相关性(r=-0.033,P=0.69)。活体肾移植后供肾者均未发生严重并发症,血清肌酐、血清尿素氮均于短期内恢复正常水平,肝肾功能均正常。结论 亲属活体肾供者GFR与年龄变化无明显相关性,对于指导活体供体的选择有重要意义。
Abstract:
Objective To quantitatively investigate the effect of age on the glomemlar filtration rate (GFR) in living-related kidney donors, to analyze the clinical value and the dependence of GFR on age and to provide an objective basis for the selection of the living kidney donor. Methods One hundred and sixtyone living-related kidney donors were divided into four age groups, namely 20-29 years(n=52), 30-39 years (n=44), 40-49 years (n=38) and ≥ 50 years (n=27). On the other hand, the total donors were divided into the groups older than 55 years (n=24) and younger than 55 years (n=137). To quantify GFR in all the subjects using the 99Tcm-diethylenetriamine pentaacetic acid (99Tcm-DTPA) renography according to standard procedure and to evaluate the effects of age on renal function. Results The total GFR in living-related kidney donors was calculated as (89.55±12.87) ml·min-1·(1.73 m2)-1. The GFR in the first to the four age groups were(88.27±12.29) ml·min-1·(1.73 m2)-1, (91.85±14.51) ml·min-1·(1.73 m2)-1, (89.25±11.26) ml·min-1·(1.73 m2)-1 and (88.24±13.20) ml·min-1·(1.73 m2)-1. The difference of GFR were not significant between the four age groups (F=2.09, P=0. 10). The GFR in the donors older than 55 years and younger than 55 years were(88.574±13.14) ml·min-1·(1.73 m2)-1 and(89.44±10.34) ml·min-1·(1.73 m2)-1, there were no significant difference in GFR between the two groups (F=1.31,P=0.25). When relating GFR to age in all the livingrelated kidney donors, there was no significant correlation (r=-0.033,P=0.69). No serious complications occurred after living kidney transplantation, serum creatinine values and blood urea nitrogen recovered to the normal levels in a short period, hepatic and renal functions were normal. Conclusion This study indicated that the GFR values were not correlated with the change of age in living-related kidney donors, and the results were helpful for the selection of living donors.

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备注/Memo

备注/Memo:
收稿日期:2010-06-21。
通讯作者:邵亚辉,E-mail:zwzhaoxy@sina.com
更新日期/Last Update: 1900-01-01