[1]袁超,李卫鹏,胡永全,等.89Sr治疗乳腺癌和前列腺癌多发性骨转移的临床观察[J].国际放射医学核医学杂志,2010,34(4):220-222.[doi:10.3760/cma.j.issn.1673-4114.2010.04.008]
　YUAN Chao,LI Wei-peng,HU Yong-quan,et al.Clinical observation of 89Sr treatment efficacy of multiple bone metastases in breast and prostate cancer patients[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(4):220-222.[doi:10.3760/cma.j.issn.1673-4114.2010.04.008]
点击复制

89Sr治疗乳腺癌和前列腺癌多发性骨转移的临床观察(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第4期
页码:
220-222
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Clinical observation of 89Sr treatment efficacy of multiple bone metastases in breast and prostate cancer patients
作者:
袁超;  李卫鹏;  胡永全;  陶健
233004, 蚌埠医学院第一附属医院核医学科
Author(s):
YUAN Chao;  LI Wei-peng;  HU Yong-quan;  TAO Jian
Department of Nuclear Medicine, The First Affiliated Hospital of Bengbu Medical College, Anhui Bengbu 233004, China
关键词:
乳腺肿瘤; 前列腺肿瘤; 肿瘤转移; 骨肿瘤; 锶放射性同位素
Keywords:
Breast neoplasms; Prostate neoplasms; Neoplasm metastasis; Bone neoplasms; Strontium radioisotopes
DOI:
10.3760/cma.j.issn.1673-4114.2010.04.008
摘要:
目的 探讨放射性核素89Sr治疗乳腺癌和前列腺癌多发性骨转移患者的临床效果。方法 回顾性分析30例乳腺癌和40例前列腺癌多发性骨转移患者接受89Sr治疗的病例资料,采用Karnofsky评分量表和骨显像方法进行疗效评估。结果 乳腺癌组的止痛总有效率为79%,前列腺癌组的止痛总有效率为85%,两组患者之间差异无统计学意义(χ2=0.78,P>0.05)。两组患者的生存质量均有明显改善,治疗前后两组患者的Karnofsky评分均有明显提高(t=2.46,P<0.05;t=2.68,P<0.05)。治疗后两组患者均未见明显骨髓抑制与肝肾功能损伤。结论 89Sr治疗乳腺癌和前列腺癌多发性骨转移止痛效果良好,患者生存质量有明显提高。
Abstract:
Objective To evaluate the efficacy of 89Sr in treatment of multiple bone metastases of breast and prostate cancer patients. Methods Seventy multiple bone metastases patients (30 females with breast cancer and 40 males with prostate cancer) were treated with 89Sr. The clinical effectiveness was assessed by Karnofsky performance score and whole body bone scanning data. Results The total pain relief rate was 79% in bone metastases of breast cancer and 85% in bone metastases of prostate cancer, respectively. There was no significant differences between the two groups (χ2=0.78, P>0.05). The Karnofsky score was significantly improved in both groups (t=2.46, P<0.05; t=2.68, P<0.05). The bone marrow depression and the damage of liver and kidney were not observed in the two groups. Conclusion The analgesic effect of 89Sr treatment was good, and the quality of life was improved in patients with multiple bone metastases breast or prostate cancer.

参考文献/References:

[1] Lipton A,Steger GG,Figueroa J,et al.Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapy.Clin Cancer Res,2008,14(20):6690-6696.
[2] Even-Sapir E,Metser U,Mishani E,et al.The detection of bone metastases in patients with high-risk prostate cancer:99Tcm-MDP planar bone scintigraphy,single- and multi-field-of-view SPECT,18F-fluoride PET,and 18F-fluoride PET/CT.J Nucl Med,2006,47(2):287-297.
[3] 中华人民共和国卫生部医政司.核医学诊断与治疗规范.北京:科学技术出版社,1997.292-295.
[4] Wong J,Hird A,Kirou-Mauro A,et al.Quality of life in brain metastases radiation trials:a literature review.Curr Oncol,2008,15(5):25-45.
[5] 赵卫威,解朋,邓候富.89Sr治疗前列腺癌骨转移的研究进展.中华男科学杂志,2010(3):269-272.
[6] 青春,邓候富,贾志云.放射性核素89Sr治疗骨转移癌的新进展.国际放射医学核医学杂志,2007,31(3):160-162.
[7] 欧阳伟,刘金华,刘伟英.89SrCl2治疗无骨痛的多发性骨转移瘤的效果.南方医科大学学报,2007,27(3):390-391.
[8] 张晓红,王鸿智,陈正国,等.89Sr治疗乳腺癌多发性骨骼转移临床疗效评价.中国肿瘤临床与康复,2008,15(3):227-228.

相似文献/References:

[1]杨雷,袁卫红,王家平,等.99Tcm-MIBI显像与钼靶X线对乳腺癌诊断的比较研究[J].国际放射医学核医学杂志,2016,40(2):111.[doi:10.3760/cma.j.issn.1673-4114.2016.02.005]
　Yang Lei,Yuan Weihong,Wang Jiaping,et al.Diagnostic value of technetium 99Tcm sestamibi and X-ray mammography in breast cancer: a comparison study[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):111.[doi:10.3760/cma.j.issn.1673-4114.2016.02.005]
[2]马乐,张万春,李晓敏.乳腺癌前哨淋巴结核素显像新进展[J].国际放射医学核医学杂志,2016,40(2):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
　Ma Le,Zhang Wanchun,Li Xiaomin.Evolution of radionuclide imaging of sentinel node lymphscintigraphy in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):145.[doi:10.3760/cma.j.issn.1673-4114.2016.02.012]
[3]王朋,崔邦平,代文莉,等.18F-FDG PET/CT在前列腺癌中的应用进展[J].国际放射医学核医学杂志,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
　Wang Peng,Cui Bangping,Dai Wenli,et al.Progress in the application of 18F-FDG PET/CT in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
[4]储小飞,赵舒怡,樊赛军.肿瘤干细胞与辐射抗性的研究进展[J].国际放射医学核医学杂志,2015,39(5):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
　chu xiaofei,zhao shuyi,fan saijun..advance progress of cancer stem cells and radioresistance[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):431.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 019]
[5]廖光星,冷志欣,肖国有.前列腺癌骨转移影像诊断方法研究进展[J].国际放射医学核医学杂志,2016,40(6):464.[doi:10.3760/cma.j.issn.1673-4114.2016.06.012]
　Liao Guangxing,Leng Zhixin,Xiao Guoyou.Progress of imaging in the diagnosis of bone metastases of prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):464.[doi:10.3760/cma.j.issn.1673-4114.2016.06.012]
[6]陈伟君,孙达.99Tcm-MIBI显像在乳腺癌新辅助化疗中的应用价值[J].国际放射医学核医学杂志,2015,39(6):487.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
　Chen Weijun,Sun Da.Clinical value of 99Tcm-MIBI imaging in neoadjuvant chemotherapy of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):487.[doi:10.3760/cma.j.issn.1673-4114.2015.06.011]
[7]胡鸿,唐刚华,聂大红.乳腺癌分子显像研究进展[J].国际放射医学核医学杂志,2015,39(1):91.[doi:10.3760/cma.j.issn.1673-4114.2015.01.019]
　Hu Hong,Tang Ganghua,Nie Dahong.Progress on molecular imaging of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):91.[doi:10.3760/cma.j.issn.1673-4114.2015.01.019]
[8]刘辰,杨悦,张雪宁,等.MRI和1997年版Partin表对前列腺癌病理特征预测准确性的对比研究[J].国际放射医学核医学杂志,2015,39(2):124.[doi:10.3760/cma.j.issn.1673-4114.2015.02.005]
　Liu Chen,Yang Yue,Zhang Xuening,et al.Accuracy of MRI and 1997 edition of Partin tables in predicting the pathological features of prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):124.[doi:10.3760/cma.j.issn.1673-4114.2015.02.005]
[9]桂继琮,刘兴党.镭-223氯化物治疗去势抵抗性前列腺癌骨转移的研究进展[J].国际放射医学核医学杂志,2015,39(3):268.[doi:10.3760/cma.j.issn.1673-4114.2015.03.018]
　Gui Jicong,Liu Xingdang.Development in the study of radium-223 chloride for treating castration-resistant prostate carcinoma with bone metastases[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):268.[doi:10.3760/cma.j.issn.1673-4114.2015.03.018]
[10]黄娟,颜剑豪,梁联保,等.注射钆剂后弥散加权成像对乳腺肿瘤诊断的影响[J].国际放射医学核医学杂志,2015,39(4):287.[doi:10.3760/cma.j.issn.1673-4114.2015.04.003]
　Huang Juan,Yan Jianhao,Liang Lianbao,et al.Evaluation of the diffusion-weighted imaging after contrast for the characterization of breast tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):287.[doi:10.3760/cma.j.issn.1673-4114.2015.04.003]

备注/Memo

备注/Memo:
收稿日期:2010-03-28。
通讯作者:袁超,E-mail:ychsysu@yahoo.com.cn
更新日期/Last Update: 1900-01-01