[1]胡旻,刘雅洁,许小飞,等.99Tcm-MIBI动态血流灌注显像和双时相核素显像对甲状腺冷结节良恶性的诊断价值研究[J].国际放射医学核医学杂志,2010,34(3):174-176.
　HU Min,LIU Ya-jie,XU Xiao-fei,et al.Study on the diagnostic value of 99Tcm-MIBI dynamic blood flow perfusion imaging and double-phase radionuclide imaging in benign and malignant cold thyroid nodules[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(3):174-176.
点击复制

99Tcm-MIBI动态血流灌注显像和双时相核素显像对甲状腺冷结节良恶性的诊断价值研究(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第3期
页码:
174-176
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Study on the diagnostic value of 99Tcm-MIBI dynamic blood flow perfusion imaging and double-phase radionuclide imaging in benign and malignant cold thyroid nodules
作者:
胡旻1;  刘雅洁2;  许小飞2;  盛丹丹2;  王颖2
1. 南京市玄武区后宰门社区卫生服务站, 210008;
2. 南京医科大学第二附属医院核医学科, 210011
Author(s):
HU Min1;  LIU Ya-jie2;  XU Xiao-fei2;  SHENG Dan-dan2;  WANG Ying2
Hou Zai Gate Community Health Service Station of Xuanwu District, Nanjing 210008, China
关键词:
甲状腺结节; 甲状腺肿瘤; 99m锝甲氧基异丁基异腈; 放射性核素显像
Keywords:
Thyroid nodule; Thyroid neoplasms; Technetium 99Tcm sestamibi; Radionuclide imaging
分类号:
10.3760/cma.j.issn.1673-4114.2010.03.013
摘要:
目的 探讨99Tcm-MIBI动态血流灌注显像和双时相显像对甲状腺冷结节良恶性的诊断价值.方法 回顾性分析甲状腺冷结节行手术治疗的患者28例,所有患者使用配备低能高分辨准直器的SPECT仪行99Tcm-MIBI动态血流灌注、30 min早期相及120 min延迟相静态平面显像,并用T/NT值等综合分析显像结果.结果 9例甲状腺癌患者在动态血流灌注、30 min早期相和120 min延迟相显像中阳性数分别为5例、6例、7例;19例良性病变患者在动态血流灌注、30 min早期相和120 min延迟相显像中阴性数分别为14例、11例、16例.99Tcm-MIBI动态血流灌注显像诊断甲状腺癌的灵敏度为55.56%,特异度为73.68%,准确率为67.85%;30 min早期相显像诊断甲状腺癌的灵敏度为66.67%,特异度为57.89%,准确率为67.85%;120 min延迟相显像诊断甲状腺癌的灵敏度为77.78%,特异度为84.21%,准确率为82.14%.结论 99Tcm-MIBI的双时相显像对甲状腺冷结节的诊断和鉴别诊断具有一定价值,通过对动态血流灌注和99Tcm-MIBI的双时相显像中T/NT值等综合分析,可以降低假阳性和假阴性的发生.
Abstract:
Objective To study the value of 99Tcm-MIBI dynamic blood flow perfusion imaging and double-phase radionuclide imaging in benign and malignant cold thyroid nodules. Methods Retrospective analysis of surgical treatment of cold thyroid nodules of 28 patients. Use dual-head SPECT with low energy and high resolution collimator to get dynamic 99Tcm-MIBI blood flow perfusion imaging, 30 min early-phase and 120 min delayed-phase static planar imaging. The images are comprehensive analysed by T/NT and other methods. Results Nine cases of thyroid cancer in the dynamic blood flow perfusion, 30 min early-phase and 120 min delayed-phase static planar imaging, contain positive imaging 5, 6 and 7 cases respectively. 19 cases of benign lesions contain negative imaging 14, 11 and 16 cases respectively. Sensitivity of 99Tcm-MIBI dynamic perfusion imaging in the diagnosis of thyroid cancer is 55.56%, specificity is 73.68%, accuracy is 67.85%. Sensitivity of 30 min early-phase static planar in the diagnosis of thyroid cancer is 66.67%, specificity is 57.89%, accuracy is 67.85%. Sensitivity of 120 min delayed-phase static planar imaging in the diagnosis of thyroid cancer is 77.78%, specificity is 84.21%, accuracy is 82.14%. Conclusions 99Tcm-MIBI dual-phase imaging in the diagnosis and differential diagnosis of cold thyroid nodules has some value,comprehensive analysis of the blood perfusion and the T/NT of 99Tcm-MIBI dual-phase imaging can reduce the occurrence of false positive and false negative cases.

参考文献/References:

[1] 马寄晓,刘秀杰.实用临床核医学. 2版.北京:原子能出版社, 2002:359-367.
[2] 李亚明,韩春起,范洋,等.99Tcm-MIBI头颈部肿瘤阳性显像临床应用研究.中国临床医学影像杂志,2000, 11(3):153-154.
[3] Elaraj DM, Clark OH. Changing management in patients with papillary thyroid cancer. Curr Treat Options Oncol, 2007, 8(4):305-313.
[4] Casara D, Rubello D, Saladini C. Role of scintigraphy with tumor-seeking agents in the diagnosis and preoperative staging of malignant thyroid nodules. Biomed Pharmacother, 2000, 54(6):334-336.
[5] Kucük ON, Aras G, Kulak HA, et al. Clinical importance of anti-thyroglobulin auto-antibodies in patients with diferentiated thyroid carcinoma:comparison with 99Tcm-MIBI scans. Nucl Med Commua 2006, 27(11):873-876.
[6] 杨爱民,李旭,薛建军,等99Tcm-MIBI肿瘤阳性显像的假阳性和假阴性分析.中华现代影像学杂志,2006,3⑵:116-118.

相似文献/References:

[1]李盼丽,宋少莉.碘难治性分化型甲状腺癌靶向药物治疗进展[J].国际放射医学核医学杂志,2016,40(3):202.[doi:10.3760/cma.j.issn.1673-4114.2016.03.009]
　Li Panli,Song Shaoli.Radioactive iodine refractory differentiated thyroid cancer targeted therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):202.[doi:10.3760/cma.j.issn.1673-4114.2016.03.009]
[2]杨珂,唐波,于夕荣,等.甲状腺癌131i治疗病房的辐射屏蔽计算与评价[J].国际放射医学核医学杂志,2015,39(5):405.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 012]
　yang ke,tang bo,yu xirong,et al.shielding calculation and assessment in 131i therapy for thyroid cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):405.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 012]
[3]陈立,陈跃.分化型甲状腺癌骨转移诊断及疗效评价的核素显像研究进展[J].国际放射医学核医学杂志,2016,40(6):452.[doi:10.3760/cma.j.issn.1673-4114.2016.06.010]
　Chen Li,Chen Yue.Diagnosis and evaluation of curative effect progress of radionuclide imaging methods in differentiated thyroid cancer of bone metastases[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(3):452.[doi:10.3760/cma.j.issn.1673-4114.2016.06.010]
[4]刘斌,潘明志.BRAF基因突变对甲状腺乳头状癌诊治价值的研究进展[J].国际放射医学核医学杂志,2015,39(2):154.[doi:10.3760/cma.j.issn.1673-4114.2015.02.011]
　Liu Bin,Pan Mingzhi.Advances in value of BRAF gene mutation on the diagnosis and treatment of papillary thyroid cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):154.[doi:10.3760/cma.j.issn.1673-4114.2015.02.011]
[5]胡斌,王锦锋,毛秋粉.18F-FDG PET/CT显像在Tg阳性131I全身显像阴性的分化型甲状腺癌患者中的应用价值[J].国际放射医学核医学杂志,2015,39(3):242.[doi:10.3760/cma.j.issn.1673-4114.2015.03.012]
　Hu Bin,Wang Jinfeng,Mao Qiufen.The application value of 18F-FDG PET/CT in patients with differentiated thyroid cancer of high thyroglobulin level and negative 131I whole body scan[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):242.[doi:10.3760/cma.j.issn.1673-4114.2015.03.012]
[6]刘鹏杰,唐铭,邓智勇,等.131I治疗儿童分化型甲状腺癌期间出现低钙血症伴癫痫发作一例[J].国际放射医学核医学杂志,2015,39(4):352.[doi:10.3760/cma.j.issn.1673-4114.2015.04.017]
[7]寇莹,刘建中,郝新忠,等.甲状腺癌131I治疗后全身扫描盆腔浓聚131I的临床分析[J].国际放射医学核医学杂志,2014,38(1):15.[doi:10.3760/cma.j.issn 1673-4114.2014.01.004]
　Kou Ying,Liu Jianzhong,Hao Xinzhong,et al.Analysis of pelvic 131I uptake after 131I whole body scan in patients with thyroid cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):15.[doi:10.3760/cma.j.issn 1673-4114.2014.01.004]
[8]李敬彦,蒋宁一.分化型甲状腺癌术后131I清甲治疗方法的相关问题[J].国际放射医学核医学杂志,2014,38(1):42.[doi:10.3760/cma.j.issn 1673-4114.2014.01.009]
　Li Jingyan,Jiang Ningyi.Issues related to radioactive iodine ablation in patients with differentiated thyroid carcinoma under-going thyroid surgery[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):42.[doi:10.3760/cma.j.issn 1673-4114.2014.01.009]
[9]马春旭,袁卫红.甲状腺结节影像学诊断研究进展[J].国际放射医学核医学杂志,2014,38(1):48.[doi:10.3760/cma.j.issn 1673-4114.2014.01.010]
　Ma Chunxu,Yuan Weihong.Advanced research on imaging diagnosis of thyroid nodule[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):48.[doi:10.3760/cma.j.issn 1673-4114.2014.01.010]
[10]成钊汀,谭建.分化型甲状腺癌术后患者131I治疗的辐射剂量与防护[J].国际放射医学核医学杂志,2014,38(2):110.[doi:10.3760/cma.j.issn.1673-4114.2014.02.010]
　Cheng Zhaoting,Tan Jian.Radiation dose and protection of differentiated thyroid carcinoma postoperative patients with 131I treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(3):110.[doi:10.3760/cma.j.issn.1673-4114.2014.02.010]
[11]惠金子,赵德善.Tg、TgAb及TSH在分化型甲状腺癌术前的预测分析[J].国际放射医学核医学杂志,2015,39(2):110.[doi:10.3760/cma.j.issn.1673-4114.2015.02.002]
　Hui Jinzi,Zhao Deshan.The prediction of risk of differentiated thyroid carcinoma with preoperative serum thyroid stimulating hormone, thyrogiobulin and antithyroglobulin antibody[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(3):110.[doi:10.3760/cma.j.issn.1673-4114.2015.02.002]
[12]龙再颖,曲新艳,单英丽.99Tcm-MIBI显像对甲状腺结节良恶性鉴别诊断价值的研究[J].国际放射医学核医学杂志,2010,34(2):80.[doi:10.3760/cma.j.issn.1673-4114.2010.02.004]
　LONG Zai-ying,QU Xin-yan,SHAN Ying-li.The diagnostic value of 99Tcm-MIBI imaging to benign and malignant thyroid lesions[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(3):80.[doi:10.3760/cma.j.issn.1673-4114.2010.02.004]
[13]杨帆,袁卫红.放射性核素显像鉴别甲状腺“冷结节”良恶性的研究进展[J].国际放射医学核医学杂志,2009,33(1):33.[doi:10.3760/cma.j.issn.1673-4114.2009.01.033]
　YANG Fan,YUAN Wei-hong.Study progress of nuclide imaging in the differential diagnosis of nonfunctional cold thyroid nodules[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(3):33.[doi:10.3760/cma.j.issn.1673-4114.2009.01.033]
[14]李昊颖.18F-氟脱氧葡萄糖PET全身显像时甲状腺意外瘤的检出及价值[J].国际放射医学核医学杂志,2007,31(3):148.
　LI Hao-ying.The value of whole body 18F-fluorodeoxyglucose PET in detecting thyroid incidentaloma[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):148.

备注/Memo

备注/Memo:
收稿日期:2010-01-08。
通讯作者:刘雅洁(E-mail:yjliu369@sina.com)
更新日期/Last Update: 1900-01-01