[1]刘长江,董燕玉.99Tcm-depreotide显像对肺部病灶的鉴别诊断价值[J].国际放射医学核医学杂志,2009,33(2):79-82,92.[doi:10.3760/cma.j.issn.1673-4114.2009.02.005]
 LIU Chang-fiang,DONG Yan-yu.The clinical value of 99Tcm-depreotide scintigraphy in differentiating malignant from benign lesions in the lung[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):79-82,92.[doi:10.3760/cma.j.issn.1673-4114.2009.02.005]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第2期
页码:
79-82,92
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The clinical value of 99Tcm-depreotide scintigraphy in differentiating malignant from benign lesions in the lung
作者:
刘长江1 董燕玉2
1. 河北省承德医学院附属医院核医学科, 承德 067000;
2. 河北省承德医学院附属医院体验中心, 承德 067000
Author(s):
LIU Chang-fiang1 DONG Yan-yu2
1. Department of Nuclear Medicine, the Affiliated Hospital of Chengde Medical College, Chengde 067000, China;
2. Medical Examination Center, the Affiliated Hospital of Chengde Medical College, Chengde 067000, China
关键词:
肺肿瘤硬币病变淋巴结肿瘤转移99Tcm-depreotide
Keywords:
Lung neoplasmsCoin lesion pulmonaryLymph nodesNeoplasm metastasis99Tcm-depreotide
DOI:
10.3760/cma.j.issn.1673-4114.2009.02.005
摘要:
Depreotide是一种人工合成的十肽生长抑素类似物,含生长抑素受体结合序列和99Tcm配位序列.通过荟萃分析肺部病灶的99Tcm-depreotide显像资料显示,99Tcm-depreotide鉴别肺部病灶良恶性的灵敏度为94.2%(95%可信区间:90.5%,97.9%),特异度为61.2%(95%可信区间:50.7%,71.7%),诊断准确率为81.6%,阳性预测值为81.1%,阴性预测值为83.2%;对于1.5 cm以下的孤立性肺结节(SPN),99Tcm-depreotide显像特异性极高,显像阳性是手术治疗的适应证;对于1.5 cm以上的SPN,因其灵敏度高,99Tcm-depreotide显像阴性者可进行系列CT扫描随访观察.
Abstract:
Depreotide is a synthetic 10-aminoacid peptide which is comprised of a somatostain receptor binding sequence and a technetium coordinating sequence. A meta-analysis is performed to estimate the diagnostic efficiency of 99Tcm-depreotide scintigraphy. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 99Tcm-depreotide SPECT in distinguishing pulmonary lesions were, respectively, 94.2% (95% confidence interval (CI):90.5%, 97.9%), 61.2% (95% CI:50.7%,71.7%), 81.6%, 81.1% and 83.2%. In patients with a small solitary pulmonary nodule (<1.5 cm) and positive 99Tcm-depreotide SPECT, the risk of malignancy is high. On the other hand, patients with a large solitary pulmonary nodule (>1.5 cm) and a negative scan may be recommended for serial CT follow-up, since the sensitivity in those subjects was high.

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备注/Memo

备注/Memo:
收稿日期:2008-12-19。
通讯作者:刘长江(E-mail:liucj_009@163.com)
更新日期/Last Update: 1900-01-01