[1]江波,刘璐.多肽类示踪技术在乳腺癌诊治中的应用进展[J].国际放射医学核医学杂志,2009,33(1):5-8.[doi:10.3760/cma.j.issn.1673-4114.2009.01.005]
　JIANG Bo,LIU Lu.Application researched progress of micromolecule polypeptide technology in diagnosis and therapy of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(1):5-8.[doi:10.3760/cma.j.issn.1673-4114.2009.01.005]
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多肽类示踪技术在乳腺癌诊治中的应用进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第1期
页码:
5-8
栏目:
分子核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Application researched progress of micromolecule polypeptide technology in diagnosis and therapy of breast cancer
作者:
江波;  刘璐
东南大学医学院核医学技术研究所, 南京 210009
Author(s):
JIANG Bo;  LIU Lu
Department of Nuclear Medical Technique, Clinical College, Southeast University, Nanjing 210009, China
关键词:
乳腺肿瘤; 肽类; 放射疗法; 受体显像
Keywords:
Breast neoplasms; Peptides; Radiotherapy; Receptor image
DOI:
10.3760/cma.j.issn.1673-4114.2009.01.005
摘要:
核素分子诊治乳腺癌在近几年发展迅速,是研究的热点。放射性核素标记的多肽受体显像是核医学中最年轻、最有活力的分支领域。当前有代表性的前沿多肽类示踪药物包括生长抑素类似物、16α-18F-17β-雌二醇、血管活性肠肽、白细胞介素11类似物环九肽、顺式11β-甲氧基-17α-123I-碘乙烯雌二醇等数种。该文综述各种多肽类药物在乳腺癌诊治中的最新进展。
Abstract:
Nuclide molecule diagnosis and therapy breast cancer is developing quite quickly in recent years, and is the hot spot of study and research. The developing of polypeptide receptor labelling by radioactivity nuclide is the most active and youngest territory branch of nuclear medicine. The nearest representative of polypeptide drug including somatostatin analogue, 18F-fluoroestradiol, vasoactive intestinal peptide, interleukin-ll analogs nine-circellus polypeptide, 11β-metoxy-17α-123I-iodovinylestradiol, this review the nearest progress of every polypeptide drug in diagnosis and therapy of breast cancer respectively.

参考文献/References:

[1] Buchholz TA,Lehman CD,Harris JR,et al.Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer,a National Cancer Institute Conference.J Clin Oncol,2008,26(5):791-797.
[2] Skanberg J,Ahlman H,Benjegard SA,et al.Indium-111-octreotide scintigraphy,intraoperative ganana-detector localisation and somatostatin receptor expression in primary human breast cancer.Breast Cancer Res Treat,2002,74(8):101-111.
[3] 王少华,于泽平,李宁,等.生长抑素受体在乳腺癌组织中表达及其临床意义.实用临床医药杂志,2006,10(2):5-7.
[4] 王少华,于泽平,李刚,等.99mTc-Sandostatin生长抑素受体显像在原发性乳腺癌诊断中的意义.医学研究生学报,2005,18(12):1120-1121.
[5] 王佳琼,王自正,姚薇萱,等.99mTc-MIBI与99mTc-Octreotide生长抑素受体显像诊断乳腺癌的对比研究.中国医学影像学杂志,2006,14(2):91-93.
[6] Van Den Bosache B,Van Belle S,De Winter F,et al.Early prediction of endocrine therapy effect in advanced breast cancer patients using 99mTe-depreotide seintigraphy.J Nucl Med,2006,47(1):6-13.
[7] 孟召伟,董峰,谭建.乳腺癌的雌激素受体显像.国际放射医学核医学杂志,2007,31(3):157-159.
[8] Mankoff DA,Peterson LM,Tewson TJ,et al.[18F]fluoroestradiol radiation desimetry in human PET studies.J Nucl Med,2001,42(4):679-684.
[9] Linden HM,Stekhova SA,Link JM,et al.Quantitative fluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer.J Clin Oncol,2006,24(18):2793-2799.
[10] Mortimer JE,Dehdashti F,Siegel BA,et al.Metabolic flare:Indicator of hormone responsiveness in advanced breast cancer.J Clin Oncol,2001,19(11):2797-2803.
[11] Zhang K,Aruva MR,Shantldy N,et al.Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP)receptor specific peptide analogues for PET imaging of breast cancer:In vitro/in vivo evaluation.Regul Pept,2007,144(1-3):91-100.
[12] Thakur ML,Aruva MR,Gariepy J,et al.PET imaging of oncogene overexpression using 64Cu-vasoactive intestinal peptide (VIP) analog:comparison with 99mTc-VIP analog.J Nucl Med,2004,45(8):1381-1389.
[13] Moody TW,Jensen RT.Breast cancer VPAC1 receptors.Ann N Y Acad Sci,2006,1070:436-439.
[14] 雷炜,梁军,陈维刚,等.重组人白细胞介素-11治疗化疗所致血小板减少的临床观察.中华肿瘤杂志,2006,28(7):542-544.
[15] Morgan H,Tumber A,Hill PA.Breast cancer cells induce osteoclast formation by stimulating host IL-11 production and downregulating granulocyte/macrophage colony-stimulating factor.Int J Cancer,2004,109(5):653-660.
[16] Wang W,Ke S,Kwon S,et al.A new optical and nuclear duallabeled imaging agent targeting interteukin 11 receptor alphachain.Bioconjug Chem,2007,18(2):397-402.
[17] Singh B,Berry JA,Shoher A,et al.COX-2 induces IL-11 production in human breast cancer cells.J Surg Res,2006,131(2):267-275.
[18] Bennink RJ,vail Tienhoven G,Rijks U,et a1.In vivo prediction of response to antiestrogen treatment in estrogen receptor-positive breast cancer.J Nucl Med,2004,45(1):1-7.

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备注/Memo

备注/Memo:
收稿日期:2008-09-26。
基金项目:国家高技术研究发展计划(863计划)项目(2007AA022471)
通讯作者:刘璐(E-mail:luliuzhou@sina.com)
更新日期/Last Update: 1900-01-01