[1]徐志英,李善春.11C-甲硫氨酸PET在乳腺癌诊疗中的价值[J].国际放射医学核医学杂志,2008,32(5):299-301.
 XU Zhi-ying,LI Shan-chun.The clinical and diagnostic value of 11C-methionine PET in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(5):299-301.
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11C-甲硫氨酸PET在乳腺癌诊疗中的价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第5期
页码:
299-301
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The clinical and diagnostic value of 11C-methionine PET in breast cancer
作者:
徐志英 李善春
264000 烟台, 烟台市毓璜项医院核医学科
Author(s):
XU Zhi-ying LI Shan-chun
Department of Nuclear Medicine, Yuhuangding Hospital, Yantai 264000, China
关键词:
乳腺肿瘤体层摄影术发射型计算机11C-甲硫氨酸
Keywords:
Breast neoplasmsTomographyemission-computed11C-methionine
摘要:
乳腺癌是我国妇女最常见的恶性肿瘤之一,也是妇女中除肺癌外病死率最高的恶性肿瘤,早期诊断是降低乳腺癌病死率的关键因素。目前,乳腺癌的诊断方法主要是钼靶X线乳腺摄影、超声检查、磁共振成像、细针穿刺活组织检查等。乳腺癌的基因变化导致癌肿血流增加,葡萄糖代谢、氨基酸转运、蛋白质合成、受体表达增加,DNA合成和细胞增殖活跃,并诱导细胞凋亡。PET结果显示,肿瘤部位对18F-氟脱氧葡萄糖(18F-FDG)和11C-甲硫氨酸(11C-MET)摄取均增高而11C-MET合成方便快捷,价格较18F-FDG低,其在乳腺癌中的应用价值国外已有诸多报道。
Abstract:
Breast cancer is one of the most ordinary malignant tumors in woman, and its mortality is only less than that of lung cancer.Early diagnosis is a key to reducing the mortality rate.The commonly used methods to diagnose breast cancer include mammography, ultrasonography, magnetic resonance imaging.Genetic changes of breast cancer comprise increased tumor blood flow, increased levels of glucose metabolism, amino acid transport, protein synthesis receptor expression, enhanced DNA synthesis and cell proliferation, and induction of apoptosis.It shows high 18F-fluorodeoxyglucose(18F-FDG) or methionine uptake in breast cancer, 11C-methionine (11C-MET) has a lower price.PET with 11C-MET has a high prognostic value in breast cancer.

参考文献/References:

[1] 邱霞,黄建.FDG PET在乳腺癌中的临床应用进展[J].实用肿瘤杂志,2006,21(1):85-88.
[2] Walter C,Scheidhauer K,Scharl A,et al.Clinical and diagnostic value of preoperative MR mammography and FDG-PET in suspicious breast lesions[J].Eur Radial,2003,13(7):1651-1656.
[3] Scheidhauer K,Walter C,Seemann MD,et al.FDG PET and other imaging modalities in the primary diagnosis of suspicious breast lesions[J].Eur J Nucl Med Mol Imaging,2004,31(Suppl 1):S70-S79.
[4] 杨国仁,张秀丽,孙晓蓉,等.FDG PET/CT联合99Tcm-SC前哨淋巴结显像诊断乳腺癌[J].中华核医学杂志,2004,24(5):312-312.
[5] 余丰文,冯彦林,贺小红,等.PET-CT与钼靶X线、B超定性诊断乳腺癌的临床对比研究[J].国际放射医学核医学杂志,2006,30(3):148-151.
[6] Buck AK,Schirrmeister H,Mattfeidt T,et al.Biological characterisation of breast cancer by means of PET[J].Eur J Nucl Med Mol Imaging,2004,31(Suppl 1):S80-S87.
[7] Kracht LW,Friese M,Herholz K,et al.Methyl-[11C]-l-methionine uptake as measured by positron emission tomography correlates to micovessel density in patients with.glioma[J].Eur J Nucl Med Mol Imaging,2003,30(6):868-873.
[8] Khan N,Oriuchi N,Ninomiya H,et al.Positron emission tomographic imaging with 11C-choline in differential diagnosis of head and neck tumors:comparison with ISF-FDG PET[J].Ann Nucl Med,2004,18(5):409-417.
[9] Inoue T,Kim EE,Wong FC,et al.Comparison of fluorine-18-fluorodeoxyglucose and carbon-11-methionine PET in detection of malignant tumors[J].J Nucl Med,1996,37(9):1472-1476.
[10] Leskinen-Kallio S,Nagren K,Lehikoinen P,et al.Uptake of 11C-methionine in breast cancer studied by PET.An association with the size of S-phase fraction[J].Br J Cancer,1991,64(6):1121-1124.
[11] Padma MV,Jacobs M,Kraus G,et al.11C-methionine PET imaging of leptomeningeal metastases from primary breast cancer-a case report[J].J Neurooncol,2001,55(1):39-44.
[12] Jansson T,Westlin JE,Ahlstr m H,et al.Positron emission tomography studies in patients with locally advanced and/or metastatic breast cancer:a method for early therapy evaluation?[J].J Clin Oncol,1995,13(6):1470-1477.
[13] Huovinen R,Leskinen-Kallio S,Nagren K,et al.Carbon-11-methionine and PET in evaluation of treatment response of breast cancer[J].Br J Cancer,1993,67(4):787-791.

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备注/Memo

备注/Memo:
收稿日期:2008-05-15。
通讯作者:李善春(E-mail:1sc718@163.com)
更新日期/Last Update: 1900-01-01