[1]董晓荣,伍钢.脑组织对DNA双链断裂的反应[J].国际放射医学核医学杂志,2008,32(1):51-54.
 DONG Xiao-rong,WU Gang.The response of the brain tissue to DNA double strand breaks[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(1):51-54.
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脑组织对DNA双链断裂的反应(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第1期
页码:
51-54
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The response of the brain tissue to DNA double strand breaks
作者:
董晓荣 伍钢
430023 武汉, 华中科技大学同济医学院附属协和医院肿瘤中心
Author(s):
DONG Xiao-rong WU Gang
Cancer Center, Wuhan Union Hospital, Huazhong University of Science and Technology, Wuhan 430023, China
关键词:
辐射损伤信号传导DNA损伤DNA修复
Keywords:
Radiation injuriesSignal transduetionDNA damageDNA repairBrain
分类号:
Q691.9
摘要:
DNA双链断裂是电离辐射引起的最严重DNA损伤形式,脑组织对DNA损伤的反应与其发展程度密切相关,脑组织中增殖细胞主要是通过同源重组进行修复,而分化细胞则通过非同源末端联接修复。DNA双链断裂信号通路相关因子的缺陷会导致一系列的有神经病理表现的人类遗传病。重点讨论电离辐射触发脑细胞DNA双链断裂后,信号转导相关因子和与相关因子导致的神经系统人类遗传疾病。
Abstract:
Double-strand breaks (DSB) are the most deleterious form of DNA damage after ionizing radiation, the response of the brain tissue to DNA damage is related to the developmental dynamics of this system. Homology recombination is particularly important for proliferating cells, while non-homologous end joining is critical for differentiating cells. Defects in the related factors to DNA damage pathway underpin many human genopathy with neuropathology. Reviewed the signal conduction system involved in the DNA DSB response and human neuropathology genopathy related to DNA DSB factors deficiencies in the brain cells.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-07-26。
通讯作者:伍钢,E-mail:wugangzr@yahoo.com.cn
更新日期/Last Update: 1900-01-01