[1]郭阳.DNA链间交联的修复与辐射敏感性[J].国际放射医学核医学杂志,2007,31(6):371-372,376.
 GUO Yang.Repair of DNA interstrand cross-links and its’ role in radiation sensitive[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(6):371-372,376.
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DNA链间交联的修复与辐射敏感性(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第6期
页码:
371-372,376
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
Repair of DNA interstrand cross-links and its’ role in radiation sensitive
作者:
郭阳
300060 天津, 天津环湖医院放疗科
Author(s):
GUO Yang
Department of Radiotherapy, Huanhu Hospital, Tianjin 300060, China
关键词:
DNA损伤DNA修复辐射耐受性DNA链间交联
Keywords:
DNA damageDNA repairRadiation toleranceDNA interstrand cross-links
分类号:
Q345.2
摘要:
实体肿瘤中存在大量的乏氧细胞。辐射可以导致这些乏氧细胞产生DNA链间交联(DNA interstrand cross-links,ICL)。ICL对细胞具有潜在的致死性毒性作用。细胞通过核酸切除修复、同源重组等方式修复ICL。但这种修复需要数小时才能完成。抑制ICL修复,有可能成为提高辐射敏感性的一种策略。
Abstract:
There are a lot of hypoxia cells in tumor tissue. These cells trend to induce the DNA interstrand cross-links (ICL) under radiation. ICL has potential lethal effect on the cells. Repair of ICL need a period of hours. It is possible to be a strategy in enhance of radiation sensitive by block the repair of ICL.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-05-25。
更新日期/Last Update: 1900-01-01