[1]冯彦林,袁建伟,余丰文,等.18F-氟脱氧葡萄糖PET-CT诊断主动脉壁粥样硬化斑块的价值探讨[J].国际放射医学核医学杂志,2007,31(2):83-85.
　FENG Yan-lin,YUAN Jian-wei,YU Feng-wen,et al.Explore the vaule of 18F-fluorodeoxyglucose PET-CT imaging in atherosclerotic plaques of aorta wall[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):83-85.
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18F-氟脱氧葡萄糖PET-CT诊断主动脉壁粥样硬化斑块的价值探讨(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第2期
页码:
83-85
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Explore the vaule of 18F-fluorodeoxyglucose PET-CT imaging in atherosclerotic plaques of aorta wall
作者:
冯彦林1; 2;  袁建伟2;  余丰文2;  刘德军2;  温广华2;  贺小红2;  黄克敏2
1. 430022 武汉, 华中科技大学同济医学院协和医院核医学科;
2. 528000 佛山, 中山大学附属佛山医院核医学科
Author(s):
FENG Yan-lin1; 2;  YUAN Jian-wei2;  YU Feng-wen2;  LIU De-jun2;  WEN Guang-hua2;  HE Xiao-hong2;  HUANG Ke-min2
1. Department of Nuclear Medcine, Union Hospital, Tongji Medcine College of Huazhong University of Science and Technology, Wuhan 430022, China;
2. Department of Nudear Medicine, the Foshan Hospital of Zhongshan University, Foshan 528000, China
关键词:
动脉粥样硬化; 不稳定性斑块; 氟脱氧葡萄糖F18; 体层摄影术; 发射型计算机
Keywords:
Atherosclerosis;  unstable plaques; Emission-computed;  tomography; Fluorodeoxy-glucoseFl8
分类号:
R817.4
摘要:
目的 通过PET-CT明确18F-氟脱氧葡萄糖在主动脉壁粥样硬化斑块中摄取程度,探讨其临床价值。方法 60例受检者,包括正常对照者6例,大动脉粥样硬化病例54例。测定主动脉壁粥样硬化部位标准化摄取值(SUV)和CT值,并依据CT值将54例主动脉壁局部18F-FDG高摄取的动脉粥样硬化病例分成3组,软斑块组CT值小于60HU,中等斑块组CT值介于60~100HU之间,钙化斑块组CT值大于100HU。第4组为正常对照组。结果 软斑块组42个测量部位的平均SUV为1.553±0.486;中等斑块组30个测量部位的平均SUV为1.393±0.296;钙化斑块组36个测量部位的平均SUV为1.354±0.189;正常对照组33个测量部位的平均SUV为1.102±0.141。多组之间比较差异具有统计学意义(F=678.909,P=0.000);正常组与各斑块组比较差异具有统计学意义。结论 18F-FDG在主动脉粥样硬化斑块中具有不同程度的摄取,其中软斑块对18F-FDG的摄取最高,提示18F-FDG PET-CT是诊断不稳定性主动脉粥样硬化斑块的有价值方法。
Abstract:
Objective To explore the clinical value of PET-CT for the diagnosis of unstable plaques in atherosclerotic lesions. Methods 60 cases underwent whole-body 18F-FDG PET-CT were retrospectively evaluated, including 6 cases with normal control group and 54 cases with atherosclerotic plaques. 54 cases with SUV and CT value in atherosclerotic lesions of large arterial wall were detected retrospectively. 54 high 18F-FDG uptake cases in atherosclerotic plaques were divided into three groups according the CT value:soft plaques group, intermediate plaques group, calcified plaques group. Group 4 was normal. Results In soft plaques group there were 42 sites whose average SUV was 1.553±0.486, in intermediate plaques group there were 30 sites whose average SUV was 1.393±0.296, in calcified plaques group there were 36 sites whose average SUV was 1.354±0.189, in normal control there were 33 sites whose average SUV was 1.102±0.141. The SUV showed significant difference among the four groups (F=678.909, P=0.000). There were significant difference between normal 18F-FDG uptake group and high 18F-FDG uptake groups. Conclusions 18F-FDG had different degree high uptake in large atherosclerotic plaques, the soft plaques had the highest 18F-FDG uptake among them. The results suggested that 18F-FDG PET-CT had significant potential valuable in the diagnosis of unstable soft plaques in atherosclerotic lesions.

参考文献/References:

1 张竹花.冠状动脉粥样硬化斑块的影像学诊断进展.国外医学:临床放射学分册,2003,26(2):78-81.
2 宋金松,朱杰等.冠状动脉粥样硬化斑块及其影像学评价.国外医学:临床放射学分册,2003,26(5):293-295.
3 Schroeder S, Kuettner A, Leitritz M, et al. Reliability of differentiating human coronary plaque morphology using contrast-enhanced multislice spiral computed tomography:a comparison with histology.J Comput Assist Tomogr, 2004, 28(4):449-454
4 Lowe GD. The relationship between infection, inflammation, and cardiovascular disease:an overview. Ann Periodontol, 2001, 6(17):1-8.
5 Ogawa M, Ishino S, Asano D, et al. 18F-FDG accumulation in atherosclerotic plaques:immunohistochemical and PET imaging study. J Nucl Med, 2004, 45(7):1245-1250.

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备注/Memo

备注/Memo:
收稿日期:2006-09-07。
通讯作者:冯彦林(E-mail:fylin@fsyyy.com)
更新日期/Last Update: 1900-01-01