[1]刘颖,王俊起.卡托普利介入99mTc-双半胱氨酸肾动态显像对肾血管性高血压患者的价值[J].国际放射医学核医学杂志,2007,31(2):86-89.
　LIU Ying,WANG Jun-qin.Value of captopril intervened 99mTc-ethylenedicysteine renal dynamic imaging in renovascular hypertension patients[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):86-89.
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卡托普利介入99mTc-双半胱氨酸肾动态显像对肾血管性高血压患者的价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第2期
页码:
86-89
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Value of captopril intervened 99mTc-ethylenedicysteine renal dynamic imaging in renovascular hypertension patients
作者:
刘颖1;  王俊起2
1. 300192 天津, 天津市第一中心医院肾内科;
2. 300192 天津, 天津市第一中心医院核医学科
Author(s):
LIU Ying1;  WANG Jun-qin2
1. Department of Nephrology, Tianjin First Central Hospital, Tianjin 300192, China;
2. Department of Nuclear Medicine, Tianjin First Central Hospital, Tianjin 300192, China
关键词:
卡托普利; 肾动态显像; 高血压; 肾血管性; 肾动脉梗阻; 99m锝双半胱氨酸
Keywords:
Captopril; Renal dynamic imaging; Hypertension;  renovascular; Renal artery obstruction; 99mTc-ethylenedicysteine
分类号:
R817.4
摘要:
目的 研究卡托普利介入99mTc-双半胱氨酸(99mTc-EC)肾动态显像对高血压患者的肾血管性原因的诊断准确性,并评价其对肾血管性高血压(RVH)患者血管成型术后肾功能改善的预测价值。方法 55例临床疑似RVH的患者,口服卡托普利50mg,60min后进行99mTc-EC肾动态显像,结果异常患者次日再进行基线水平肾动态显像。按照显像结果将RVH的诊断分为高度可能组、不确定组和低度可能组。结果 高度可能组的22例患者中20例有肾动脉狭窄(RAS);不确定组10例中的5例有RAS;低度可能组23例均证实没有RAS。如果将不确定诊断组和低度可能组归为阴性,诊断RAS的灵敏度为80%,特异度为93.3%,阳性预测值为90.9%,阴性预测值为84.8%;如果将高度可能组和不确定诊断组归为阳性,则灵敏度、特异度、阳性预测值和阴性预测值分别为100%、77.7%、78.7%、100%。22例RVH患者进行介入治疗,高度可能组的18例患者中16例治疗有效,不确定组中3例无效、1例有效。结论 卡托普利介入99mTc-EC肾动态显像是诊断RVH的有效手段,同时能预测患者血管成形术治疗效果。
Abstract:
Objective To show the value of captopril renal scintigraphy for detecting a renovascular cause in hypertensive patients and to assess the ability to predict the beneficial effect of revascularization on renal function. Methods Fifty-five consecutive patients with suspected renovascular hypertension (RVH) underwent renal scintigraphy after injection of 99mTc ethylenedicysteine (99mTc-EC) after oral administration of 50 mg captopril given 60 min before the test. Baseline scintigraphy was performed 24 h later if the 99mTc-EC results were abnormal. Results 20 patients had renal artery stenosis(RAS) in 22 patients whom scintigraphy had a high probability of RVH. The result was indeterminate in 10 patients, 5 of them had RAS. In 23 patients found a low probability RVH. In 18 of 22 patients with a high probability RVH by scintigraphy, revascularization procedures were performed and 16 patients had beneficial effects, 1 of 4 patients with intermediate RVH had beneficial effects. Conclusion Captopril renal scintigraphy can detect and can predict the beneficial effect of revascularization in some cases.

参考文献/References:

1 Vaughn ED. Renovascular hypertension. Curr Opin Urol, 1998, 8(2):125-128.
2 Taylor AT, Donald M, Dubovsky EV, et al. Procedure guideline for diagnosis of renovascular hypertension. Society of Nuclear Medicine Procedure guidelines manal, 2003.98-104.
3 Fenves AZ, Ram CV. Renovascular hypertension:Clinical concepts.Minerva Med, 2006, 97(4):313-324.
4 Kerut EK, Geraci SA, Faltman C, et al. Atherosclerotic renal artery stenosis and renalvascular hypertension:clinical diagnosis and indications for revascularization. J Clin Hypertens, 2006, 8(7):502-509.
5 Jensen G, Moonen M, Aurell M, et al. Reliability of ACEI enhanced 99mTc-DTPA gamma camera renography in the detection of renovascular hypertension. Nucl Med Commun, 1993, 14(3):169-175.
6 Grenier N, Hauger O, Cimpean A, et al. Update of renal imaging.Semin Nucl Med, 2006, 36(1):2-15.
7 Mittal BR, Kumar P, Arora P, et al. Role of eaptopril renography in the diagnosis of renovascular hypertension. Am J Kidney Dis, 1996,28(2):209-213.
8 Philippe F, Delphine M, Roselyne J, et al. Value of eaptopril scintigraphy in hypertension patients with renal failure. J Nucl Med,1999, 40(3):412-417.
9 Ludwig V, Martin WH, Delbeke D. Calcium channel blockers:a potential cause of false-positive captopril renography. Clin Nucl Med, 2003, 28(2):108-112.
10 Taylor AT, Nally J, Aurell M, et al. Procedure guideline for diagnosis of renovascular hypertension. J Nucl Med, 1998, 39(7):1297-1302.

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备注/Memo

备注/Memo:
收稿日期:2006-11-16。
通讯作者:刘颖(E-mail:yingliu@gmail.com)
更新日期/Last Update: 1900-01-01