[1]徐海青,吴边.131I合并小剂量碳酸锂治疗Graves病的临床探讨[J].国际放射医学核医学杂志,2006,30(3):151-152.
　XU Hai-qing,WU Bian.Clinical investigation of 131I therapy combined with low-dose lithium carbonate for Graves disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(3):151-152.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第3期
页码:
151-152
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Clinical investigation of 131I therapy combined with low-dose lithium carbonate for Graves disease
作者:
徐海青;  吴边
246003 重庆, 安徽省安庆市立医院核医学科
Author(s):
XU Hai-qing;  WU Bian
Department of Nuclear Medicine, Anqing City Hespital, Anhui Anqing 246003, China
关键词:
格雷夫斯病; 碘放射性同位素; 碳酸锂; 药物疗法; 联合; 随访研究
Keywords:
Graves disease; Iodine radioisotopes; Lithium carbonate; Drugtherapy; combination; Follow-up investigation
分类号:
R817.5
摘要:
目的 探讨放射性核素131I合并小剂量碳酸锂治疗Graves病的临床疗效。方法 治疗前口服碳酸锂250mg,1次/d,共5周。于第三周末给予Graves患者一次性口服131I,剂量为3.15MBq(80uCi)/g甲状腺组织的60%~70%。随访时间6~24个月(平均14个月),按随访结果分成痊愈、好转、无效三类。结果 单次131I合并小剂量碳酸锂治疗Graves患者,痊愈率(106例)、好转率(28例)、无效率(8例)分别为74.6%、19.7%、5.6%,对23例Graves患者进行重复治疗(未再次服用碳酸锂)后痊愈为10例、好转8例、无效5例,分别占43.5%、34.8%、21.7%。其中,首次131I治疗后半年随访为甲状腺功能减退症(简称甲减)者25例,占17.6%。结论 131I合并小剂量碳酸锂治疗Graves病疗效显著,同时可以减少131I的使用剂量,降低了药物的毒性反应。
Abstract:
Objective To investigate the clinical curative effects of 131I therapy combined with low-dose lithium carbonate for Graves disease.Methods Patients with Graves disease took lithium carbonate (250mg, once per day) orally for 5 weeks. Then they were treated with 131I (doses=3.15 MBq(80 uCi)/g, based on 60%~70% of the thyroid size). We kept track from 6 to 24 months (averaging 14 months) and classified the results into three:cured, improved or no effect.Results After a single cycle of 131I therapy combined with low-dose lithium carbonate, 106 patients with Graves disease were cured, 28 were improved and 8 saw no effects, respectively 74.6%,19.7% and 5.6% among the 142 patients. We then treated 23 of them with another 131I therapy (without lithium carbonate). 10 of such were cured (43.5%), 8 were improved (34.8%) and the other 5 saw no effects. Among all patients, hypothyroidism was observed from 25 (17.6%), 6 months after the first 131I therapy.Conclusions Notable curative results were observed from 131I therapy combined with low-dose lithium carbonate for Graves disease. Moreover, the dosage of 131I was therefore decreased, which also lowered the toxicity response.

参考文献/References:

1 谭天秩.放射性核素治疗.临床核医学.第二版.北京:人民卫生出版社,1993,1218-1231.
2 谭天秩.放射性核素治疗.见:中华人民共和国卫生部医政司主编.核医学诊断与治疗规范.北京:科学出版社,1997.280-287.
3 Bogazzi F, Bartalena L, Brogioni S, et al. Comparison of radioiodine with mdioiodine plus lithium in the treatment of Graves thperthyroidism.J Clin Endocrinol Metab, 1999, 84(2):499-503.
4 丁昊, 匡安仁, 管昌田. 碳酸锂增强分化型甲状腺癌术后残留甲状腺131I吸收剂量的研究.中华核医学杂志,2003,23(2)80-81.
5 Mazzaferri EL Kloos RT. Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab,2001, 86(4):1447-1463.

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备注/Memo

备注/Memo:
收稿日期:2006-02-17。
通讯作者:徐海青(E-mail:xuhaiqing1972@163.com)
更新日期/Last Update: 1900-01-01