[1]李祖贵.轻度认知障碍的功能性神经影像学研究进展[J].国际放射医学核医学杂志,2006,30(2):76-79.
 LI Zu-gui.The progress of functional neuroimaging in the study of mild cognitive impairment[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):76-79.
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轻度认知障碍的功能性神经影像学研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第2期
页码:
76-79
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The progress of functional neuroimaging in the study of mild cognitive impairment
作者:
李祖贵
300052 天津, 天津医科大学总医院PET-CT中心
Author(s):
LI Zu-gui
PET-CT Center, General Hospital of Tianjin Medical University, Tianjin 300052, China
关键词:
认知障碍体层摄影术发射型计算机体层摄影术发射型计算机单光子磁共振成像功能性阿尔茨海默病
Keywords:
Cognition disoerdersTomographyemission-computedTomographyemission-computedsingle-photonMagnetic resonance imagingfunctionalAlzheimer’s disease
分类号:
R445.2;R817.4
摘要:
轻度认知障碍(MCI)是正常老化过程与早期阿尔茨海默病(AD)之间的一种中间过渡状态,具有进展为AD的高度危险性。功能性神经影像学手段(如PET、SPECT、fMRI脑显像)能对MCI脑代谢、血流灌注特点进行正确评价,有助于AD的早期诊断、病程监测、疗效观察及临床治疗个体的选择。
Abstract:
Mild cognitive impairment (MCI) represents a transitional state between healthy aging and very mild Alzheimer’s disease. MCI patients have a substantially higher rate of progression to Alzheimer’s disease compared with cognitively normal elderly people. Functional neuroimaging modalities, including PET、SPECT and functional MRI show that MCI patients have special abnormalities in brain metabolism and perfusion, so they can offer great value in the predicting cognitive decline and early diagnosis of dementia.

参考文献/References:

1 Petersen RC,Smith GE,Waring SC,et al.Mild cognitive impairment:clinical characterization and outcome.Arch Neurol,1999,6(3):303-308.
2 Petersen RC,Doody R,Kurz A,et al.Current concepts in mild cognitive impairment.Arch Neurol,2001,58(12):1985-1992.
3 Celsis P.Age-related cognitive decline,mild cognitive impairment or preclinical Alzheimer’s disease?.Ann Med,2000,32(1):6-14.
4 Bennett DA,Schneider JA,Bienias JL,et al.Mild cognitive impairment is related to Alzheimer’s disease pathology and cerebral infarctions.Neurology,2005,64(5):834-841.
5 Johnson NA,Jahng GH,Weiner MW,et al.Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging:initial experience.Radiology,2005,234(3):851-859.
6 Kantarci K,Jack CR Jr,Xu YC,et al.Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease:A 1H MRS study.Neurology.2000,55(2):210-217.
7 Kantarci K,Peterson RC,Boeve BF,et al.DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment.Neurology,2005,64(5):902-904.
8 Machulda MM,Ward HA,Borowski B,et al.Comparison of memory fMRI response among normal,MCI,and Alzheimer’s patients.Neurology,2003,61(4):500-506.
9 Kogure D,Matsuda H,Ohnishi T,et al.Longitudinal evaluation of early Alzheimer’s disease using brain perfusion SPECT.J Nucl Med,2000,41(7):1155-1162.
10 Encinas M,Juan R,Marcos A,et al.Regional cerebral blood flow assessed with 99mTc-ECD SPET as a marker of progression of mild cognitive impairment to Alzheimer’s disease.Eur J Nucl Med Mol Imaging,2003,30(11):1473-1480.
11 Okamura N,Arai H,Maruyama M,et al.Combined analysis of CSF Tau levels and[123I] iodoamphetamine SPECT in mild cognitive impairment:implications for a novel predictor of Alzheimer’s disease.Am J Psychiatry,2002,159(3):474-476.
12 Drzezga A,Lautenschlager N,Siebner H,et al.Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer’s disease:a PET follow-up study.Eur J Nucl Med Mol Imaging,2003,30(8):1104-1113.
13 Small GW,Ercoli LM,Sliverman DH et al.Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease.Proc Natl Acad Sci USA,2000,97(11):6037-6042.
14 Chételat G,Desgranges B,de la Sayette V,et al.Mild cognitive impairment can FDG-PET predict who is to rapidly convert to Alzheimei’s disease?.Neurology,2003,60(8):1374-1377.
15 Mosconi L,Perani D,Sorbi S,et al.MCI conversion to dementia and the APOE genotype.A prediction study with FDG PET.Neurology,2004,63(12):2332-2340.
16 Arnáiz E,Jelic V,Almkvist O,et al.Impairment cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment.Neuroreport,2001,12(4):851-855.

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备注/Memo

备注/Memo:
收稿日期:2005-06-29。
更新日期/Last Update: 1900-01-01