[1]张佳胤,李彪.正电子药物在肿瘤诊断中的进展[J].国际放射医学核医学杂志,2006,30(1):30-35.
 ZHANG Jia-yin,LI Biao.The development of positron emission tomography tracers in the diagnosis of malignant tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):30-35.
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正电子药物在肿瘤诊断中的进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第1期
页码:
30-35
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The development of positron emission tomography tracers in the diagnosis of malignant tumors
作者:
张佳胤 李彪
200025 上海, 上海瑞金医院核医学科
Author(s):
ZHANG Jia-yin LI Biao
Department of Nuclear Medicine, Ruijin Hospital, Shanghai 200025, China
关键词:
肿瘤体层摄影术发射型计算机脱氧葡萄糖
Keywords:
TumorTomographyemission-computedDeoxyglucose
分类号:
R817.4
摘要:
正电子发射型体层显像(PET)在肿瘤的早期诊断、分期、良恶性鉴别以及复发监测中有着广泛的应用。18F-氟代脱氧葡萄糖(18F-FDG)是目前最成熟的正电子肿瘤显像剂,但是18F-FDG在部分肿瘤中的显像结果并不理想。11C-甲硫氨酸(11C-MET)、11C-乙酸(11C-acetate)、11C-胆碱(11C-choline)、18F-脱氧胸苷(18F-FLT)等各类非葡萄糖代谢的正电子显像剂逐渐投入临床使用,它们将和18F-FDG互补,提高各种肿瘤诊断的敏感性、特异性和准确率。
Abstract:
Positron emission tomography(PET) is widely used in early diagnosis, staging, post-treatment follow-up of malignant tumors as well as the differentiation between benign and malignant tumor. So far, 18F-fluorodeoxyglucose (18F-FDG) is the most popular and mature PET tracer according to its excellent performance in various types of cancer. But in some kind of cancers, 18F-FDG fails to accurately diagnose them. Now with the clinical application of non-glucose metabolic PET tracers like 11C-methionine (11C-MET), 11C-acetate、11C-choline and 18F-fluorodeoxythymidine(18F-FLT), they complement 18F-FDG in improving the sensitivity, specificity and accuracy of tumor diagnosis.

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备注/Memo

备注/Memo:
收稿日期:2005-12-10。
通讯作者:李彪(E-mail:biaoli63@hotmail.com)
更新日期/Last Update: 1900-01-01