[1]闵锐,李雨,潘真.辐射损伤的分类及诊断——介绍美国国家战略储备辐射工作组关于急性放射病治疗的建议之一[J].国际放射医学核医学杂志,2005,29(4):179-185,封三.
 MIN Rui,LI Yu,PAN Zhen.Triage and diagnosis of radiation injuries——Introduction of a suggestion on acute radiation sickness therapy made by strategic national stockpile radiation working group of USA. Part 1[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(4):179-185,封三.
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辐射损伤的分类及诊断——介绍美国国家战略储备辐射工作组关于急性放射病治疗的建议之一(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第4期
页码:
179-185,封三
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Triage and diagnosis of radiation injuries——Introduction of a suggestion on acute radiation sickness therapy made by strategic national stockpile radiation working group of USA. Part 1
作者:
闵锐 李雨 潘真
200433 上海, 上海第二军医大学海军医学系放射医学教研室
Author(s):
MIN Rui LI Yu PAN Zhen
Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China
关键词:
辐射损伤个体辐射剂量分类诊断
Keywords:
radiation injuryindividual exposure dosetriagediagnosis
分类号:
R818.04
摘要:
美国国家战略储备辐射工作组根据可能遭受到的放射性恐怖袭击,制定了不同急性照射剂量范围、出现不同数量伤员的救治方案,为内科和相关医疗专业的医生提供评估和处理大规模辐射损伤伤员的基本临床指南。该建议以恶心、呕吐发生的时间和严重性,照射后数小时及数日内淋巴细胞下降绝对值,以及外周血淋巴细胞染色体畸变率(包括双着丝粒和染色体环)来评估个体受照射剂量。各个时期出现的造血、胃肠道、脑血管和皮肤系统的临床征兆和症状等是病人分类、选择治疗和预后的重要信息。
Abstract:
Strategic National Stockpile Radiation Working Group developed a consensus document to provide a framework for physicians in internal medicine and the medical subspecialties to evaluate and manage large-scale radiation injuries for aiding individuals injured by a terrorist act involving radioactive material. Scenarios have been developed for such acts that include a range of exposures resulting in few to many casualties. Individual radiation dose is assessed by determining the time to onset and severity of nausea and vomiting, decline in absolute lymphocyte count over several hours or days after exposure, and appearance of chromosome aberrations (including dicentrics and ring forms) in peripheral blood lymphocytes. Documentation of clinical signs and symptoms (affecting the hematopoietic, gastrointestinal, cerebrovascular, and cutaneous systems) over time is essential for triage of victims, selection of therapy, and assignment of prognosis.

参考文献/References:

1 Shigematsu I, Kamada N, Akiyama M, et al. A-bomb radiation effects digest[M]. Tokyo, Bunkodo/Chur:Harwood Academic, 1993.
2 Schull WJ. Effects of atomic radiation:A half-century of studies from Hiroshima and Nagasaki[M]. New York:J Wiley, 1996.
3 Anno GH, Young RW, Bloom RM, et al. Dose response relationships for acute ionizing-radiation lethality[J]. Health Phys, 2003, 84(5):565-575.
4 National Council on Radiation Protection and Measurements. Management of terrorist events involving radioactive material[C]. Bethesda, MD:NCRP Publication No. 138, 2001.54-73.
5 Institute of Medicine/National Research Council. Potential Radiation Exposure in Military Operations:protecting the soldier before,during and after. Committee on Battlefield Radiation Exposure Criteria[M]. Washington DC:National Academy Pr, 1999.
6 Fliedner, TM, Friesecke, I, Beyrer K. Medical Management of Radiation Accidents:Manual on the Acute Radiation Syndrome[M]. Oxford:British Institute of Radiology, 2001.
7 Goans RE, Holloway EC, Berger ME, et al. Early dose assessment in criticality accidents[J]. Health Phys, 2001, 81(4):46-49.
8 Voisin P, Barquinero F, Blakely B, et al. Towards a standardization of biological dosimetry by cytogenetics[J]. Cell Mol Biol, 2002, 48(5):501-504.
9 Voisin P, Benderitter M, Claraz M, et al. The cytogenetic dosimetry of recent accidental overexposure[J]. Cell Mol Biol, 2001, 47(3):557-564.
10 Prasanna PG, Subramanian U, Greenhill RG, et al. Cytogenetic biodosimetry strategy for potential radiation mass casualties. In:The Health Physics Society Midyear Topical Meeting on Homeland Defense and Emergency Response. 36th HPS Topical Meeting[C].Washington DC:Health Physics Society, 2003. 218-223.
11 Amundson SA, Do KT, Shahab S, et al. Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation[J]. Radiat Res, 2000, 154(3):342-346.
12 Amundson SA, Fornace AJ Jr. Gene expression profiles for monitoring radiation exposure[J]. Radiat Prot Dosimetry, 2001, 97(1):11-16.
13 Schreyer SK, Karkanitsa LV, Albanese J, et al. Analysis of radiationassociated changes in gene expression using microarray technology[J]. Br J Radiol, 2002, 26(Suppl):129-139.
14 Grace MB, McLeland CB, Blakely WF. Real-time quantitative RTPCR assay of GADD45 gene expression changes as a biomarker for radiation biodosimetry[J]. Int J Radiat Biol, 2002, 78(11):1011-1021.
15 Walker RI, Cerveny RJ. Medical Consequences of Nuclear Warfare[M]. Falls Church, VA:Office of the Surgeon Genera l. 1989.
16 Dainiak N. Hematologic consequences of exposure to ionizing radiation[J]. Exp Hematol, 2002, 30(6):513-528.
17 Military Medical Operations Office. Medical Management of Radiological Casualties-Handbook[M]. 2nd ed. Bethesda:Armed Forces Radiology Research Institute, 2003.
18 Barabanova AV. Acute radiation syndrome with cutaneous syndrome[A]. Ricks RC, Berger ME, O’Hara FM, eds. The medical basis for radiation accident preparedness:The clinical care of victims[C]. New York:Parthenon; 2002:217-224.
19 Peter RU. Management of skin injuries in radiation accidents:the cutaneous radiation syndrome[A]. Ricks RC, Berger ME, O’ Hara FM, et al. The medical basis for radiation-accident preparedness:the Clinical Care of Victims[C]. New York:Parthenon, 2002.225-229.

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备注/Memo

备注/Memo:
收稿日期:2005-04-07。
更新日期/Last Update: 1900-01-01