[1]李蓉.AL杂交细胞在放射生物学研究中的应用[J].国际放射医学核医学杂志,2004,28(1):30-33.
　LI Rong.The application of AL hybrid cells in radiobiology study[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(1):30-33.
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AL杂交细胞在放射生物学研究中的应用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
28
期数:
2004年第1期
页码:
30-33
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
The application of AL hybrid cells in radiobiology study
作者:
李蓉
400038 重庆, 第三军医大学全军复合伤研究所
Author(s):
LI Rong
Institute of Combined Injuries Third Military Medical University, Chongqing 400038, China
关键词:
AL杂交细胞; 突变; 染色体; 基因
Keywords:
human-hamster hybrid AL cell; mutation; chromosome; gene
分类号:
Q345+.2
摘要:
AL杂交细胞是近年来研究负荷粒子致突变效应较理想的一种分析体系,可用于直接检测低剂量突变因子的效应。用此体系研究某些人类基因之间的连锁非常方便,体系灵敏度高,具有其他体系细胞所不具备的优势,在放射生物学中可作为研究致突变效应的一种很好的工具。
Abstract:
The AL cell assay employs a human-hamster hybrid cell lines which contains a sin-gle human chromosome-number 11.AL cells are convenient for studying linkage between selected human genes-and detecting effect of low-dose mutant.AL cells will aid in the understanding of the mutagenic effects of different types of ionizing radiation.

参考文献/References:

[1] Gustafson DL, Franz HR, Tom SM, et al. Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not (137)Cs gamma-radiation at the CD59 locus in human-hamster hybrid AL cell[J].Mutagenesis, 2000,15(3):207-213
[2] Zhou H, Zhu LX, Li K, et al. Radon, tobacco-specific nitrosamine and mutagenesis in mammalian cells[J]. Mutat Res, 1999, 430(1):145-153.
[3] Zhou HN, Masao Suzuki, Charles RG, et al. Effects of irradiated medium with or without cells on bystander cell responses[J]. Mutat Res/Fundament Mol Mechanisms of Mutagenesis, 2002, 499(2):135-141.
[4] Zhou HN, Xu A, Masao Suzuki, et al. The Yin and Yan of by stander versus adaptive response:lessons from the microbeam studies[J]. Int congress series radiat and homeostasis. 2002, 1236:241-247.
[5] Wedemeyer N, Greve B, Uthe D, et al. Frequency of CD59 mutations induced in human-hamster hybrid AL cells by low-dose X-irradiation[J]. Mutat Res, 2001, 473(1):73-84.
[6] Wu L J, Santella RM, Hei TK. Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells[J]. Cancer Res, 1999, 59(23):5922-5926.
[7] Xu A, Zhou H, Yu DZ, et al. Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells:implication from mutation patterns induced by reactive oxygen species[J].Environ Health Perspect, 2002, 110(10):1003-1008.
[8] Kessel M, Liu SX, Xu A, et al. Arsenic induces oxidative DNA damage in mammalian cells[J]. Mol Cell Biochem 2002, 234(1-2):301-308.
[9] Wu L J, Randers-pehrson G, Xu A, et al. Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells[J]. Proc Natl Acad Sci USA 1999, 96(9):4959-4964.
[10] Kraemer SM, Vannais DB, Kronenberg A, et al. Gamma-ray mutagenesis studies in a new human-hamster hybrid,ALCD59(+/-), which has two human chromosomes 11 but is hemizygous for the CD59 gene[J]. Radiat Res, 2001, 156(1):10-19.
[11] Kraemer SM, Kronenberg A, Ueno A, et al. Measuring the spectrum of mutation induced by nitrogen ions and protons in the human-hamster hybrid cell line ALC[J]. Radiat Res,2000, 153(6):743-751.
[12] Vannais D, Drabek R, Gustafson D, et al. Analysis of mutant quantity and quality in human-hamster hybrid AL and AL-179 cells exposed to 137Cs-gamma or HZE-Fe ions[J].Adv Space Res, 1998,22(4):579-585.

相似文献/References:

[1]袁雄,叶常青.重离子辐射的细胞突变效应[J].国际放射医学核医学杂志,1997,21(1):42.
[2]卜桂兰,王彬.体细胞HPRT基因位点在电离辐射及其它致突物质研究中的应用[J].国际放射医学核医学杂志,1997,21(2):91.

备注/Memo

备注/Memo:
收稿日期:2003-09-12。
更新日期/Last Update: 1900-01-01