[1]袁志斌.正电子肿瘤阳性显像剂18F-AMT[J].国际放射医学核医学杂志,2002,26(5):193-195.
　YUAN Zhi-bin.Tumor positive positron imaging agent 18F-AMT[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(5):193-195.
点击复制

正电子肿瘤阳性显像剂18F-AMT(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第5期
页码:
193-195
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Tumor positive positron imaging agent 18F-AMT
作者:
袁志斌
200233 上海, 上海市第六人民医院核医学科
Author(s):
YUAN Zhi-bin
Department of Nuclear Medicine Shanghai 6th People’s Hospital, Shanghai 200233, China
关键词:
正电子发射体层显像; 18F-α-甲基酪氨酸; 18F-氟代脱氧葡萄糖; 对比研究
Keywords:
positron emission tomography; 18F-α-methyl-tyrosine; 18F-fluorodeoxyglucose; comparison study
分类号:
R817.4
摘要:
18F-AMT(18F-α-methyl-tyrosine,18F-α-甲基酪氨酸)是新研制的一种正电子肿瘤阳性显像剂。18F-AMT的合成方法较简单,在肿瘤/非靶组织的比值高于18F-FDG(18F-氟代脱氧葡萄糖),特别是在脑肿瘤显像方面较18F-FDG显示更大的优越性。
Abstract:
18F-AMT (18F-α-methyl-tyrosine)is a newly developed positron tumor positive imaging agent.In this review the synthesis method,biodistribution,in vitro study and clinical application result of 18F-AMT are discussed separately.

参考文献/References:

[1] Bomanji JB, Costa DC, Ell PJ. Clinical role of positron emission tomography in oncology[J]. Lancet Oncol, 2001, 2(3):157-164.
[2] Schmiolt D, Gottand U, Langen KJ, et al. 3-[123] Iodoalpha-methyl-L-tyrosine uptake in cerebral gliomas:relationship to histological grading and prognosis[J]. Eur J Nucl Med, 2001, 28(7):855-861.
[3] Tomiyoshi K, Amed K, Muhammad S, et al. Synthesis of isomers of 18F-labelled amino acid radiopharmaceutical:position 2- and 3-L-18F-alpha-methyltyrosine using a separation and purification system[J]. Nucl Med Commun, 1997,18(2):169-175.
[4] Inoue T, Tomiyoshi K, Higuchi T, et al. Biodistribution studies on L-3-[fluorine-18]fluoro-alpha-methyl tyrosine:a potential tumor-detecting agent[J]. J Nucl Med,1998, 39(4):663-667.
[5] Tomiyoshi K, Inoue T, Higuchi T, et al. Metabolic studies of [18F-alpha-methyl]tyrosine in mice bearing colorectal carcinoma LS180[J]. Anticancer Drugs, 1999, 10(3):329-336.
[6] Amano S, Inoue T, Tomiyoshi K, et al. In vivo somparison of PET and SPECT radiopharmaceuticals in detecing breast cancer[J]. J Nucl Med, 1998, 39(8):1424-1427.
[7] Inoue T, Koyama K, Oriuchi N, et al. Detection of malignant tumors:whole-body PET with fluorine-18 alpha-methyl tyrosine versus FDG-prelimary study[J]. Radiology, 2001, 220(10):54-62.
[8] Inoue T, Shibasaki T, Oriuchi N, et al. 18F-alpha-methyl tyrosine PET stidies in patients with brain tumors[J]. J Nucl Med, 1999, 40(3):399-405.
[9] Watanabe H, Inoue T, Shinozali T, et al. PET imaging of musculoskeletal tumors with fluorine-18 alpha-methyltyrsine:comparison with fluorine-18 fluorodeoxyglucose PET[J]. Eur J Nucl Med, 2000, 27(10):1509-1517.

相似文献/References:

[1]左传涛.脑中风患者脑功能重塑研究中应注意的问题[J].国际放射医学核医学杂志,2005,29(1):1.
　ZUO Chuan-tao.The issues in the study of brain plasticity after stroke[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):1.
[2]蔡莉,李彦生.氟代脱氧葡萄糖与氨基酸PET在脑肿瘤中的对比研究[J].国际放射医学核医学杂志,2005,29(1):10.
　CAI Li,LI Yan-sheng.Comparison of 18F-FDG and amino acid PET imaging in brain tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):10.
[3]董爱生,田建明.部分癫痫的神经影像学诊断[J].国际放射医学核医学杂志,2005,29(4):148.
　DONG Ai-sheng,TIAN Jian-ming.Neuroimaging in the diagnosis of partial epilepsy[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):148.
[4]季仲友.PET-CT中诊断性CT的必要性与临床应用[J].国际放射医学核医学杂志,2005,29(5):197.
　JI Zhong-you.Necessity and clinical application of diagnostic CT in PET-CT scanner[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):197.
[5]陈香,赵军,管一晖.PET-CT常见伪影[J].国际放射医学核医学杂志,2005,29(5):201.
　CHEN Xiang,ZHAO Jun,GUAN Yi-hui.Common artifacts on PET-CT images[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):201.
[6]吴湖炳.18F-氟代脱氧葡萄糖PET-CT在头颈部肿瘤中的应用价值[J].国际放射医学核医学杂志,2005,29(5):205.
　WU Hu-bing.The clinical application value of 18F-FDG PET-CT on the head and neck cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):205.
[7]董孟杰,林祥通,赵军.PET-CT在卵巢癌中的临床应用价值[J].国际放射医学核医学杂志,2005,29(5):209.
　DONG Meng-jie,LIN Xiang-tong,ZHAO Jun.The application of PET-CT in ovarian cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):209.
[8]刘建军,黄钢.18F-氟代脱氧葡萄糖PET和PET-CT在转移性骨肿瘤中的应用研究[J].国际放射医学核医学杂志,2005,29(5):213.
　LIU Jian-jun,HUANG Gang.Application study of 18F-FDG PET and PET-CT on malignant bone metastases[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):213.
[9]华逢春,管一晖,赵军.18F-氟代脱氧葡萄糖PET及PET-CT在淋巴瘤中的临床应用[J].国际放射医学核医学杂志,2005,29(5):216.
　HUA Feng-chun,GUAN Yi-hui,ZHAO Jun.18F-FDG PET and PET-CT imaging in lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):216.
[10]黎海涛.PET-CT在乳腺癌诊断中的应用价值[J].国际放射医学核医学杂志,2005,29(5):220.
　LI Hai-tao.The application value of PET-CT in the diagnosis of breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):220.

备注/Memo

备注/Memo:
收稿日期:2002-05-23。
作者简介:袁志斌(1969-),男,副主任技师,主要从事放射性药物的研究工作。
更新日期/Last Update: 1900-01-01