[1]武萍,李思进,张艳兰,等.基于30mA管电流低剂量呼吸门控PET/CT扫描条件的建立讨论[J].国际放射医学核医学杂志,2013,37(5):257-261.[doi:10.3760/cma.j.issn.1673-4114.2013.05.001]
　WU Ping,LI Si-jin,ZHANG Yan-lan,et al.Low-dose respiratory-gated PET/CT: based on 30 mA tube current[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(5):257-261.[doi:10.3760/cma.j.issn.1673-4114.2013.05.001]
点击复制

基于30mA管电流低剂量呼吸门控PET/CT扫描条件的建立讨论(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第5期
页码:
257-261
栏目:
论著
出版日期:
2013-09-25

文章信息/Info

Title:
Low-dose respiratory-gated PET/CT: based on 30 mA tube current
作者:
武萍;  李思进;  张艳兰;  郝新忠;  秦志星;  鄢敏;  程鹏亮;  武志芳
030001 太原, 山西医科大学第一医院核医学科
Author(s):
WU Ping;  LI Si-jin;  ZHANG Yan-lan;  HAO Xin-zhong;  QIN Zhi-xing;  YAN Min;  CHENG Peng-liang;  WU Zhi-fang
Department of Nuclear Medicine, the First Hospital of Shanxi Medical University, 030001 Taiyuan, China
关键词:
辐射剂量; 正电子发射断层显像术; 体层摄影术; X线计算机; 呼吸门控
Keywords:
Radiation dosage; Positron-emission tomography; Tomography;  X-ray computed; Respiratory gated
DOI:
10.3760/cma.j.issn.1673-4114.2013.05.001
摘要:
目的 通过改善呼吸门控PET/CT(RG PET/CT)的扫描参数(如管电流、呼吸时相数目、呼吸周期等),拟建立一个低辐射剂量且图像质量适于临床的扫描条件。方法 对26例有18F-FDG摄取的肺结节患者行1个床位的低剂量RG PET/CT(30 mA,1 min/时相),评估其辐射剂量,并对比其与常规PET/CT(120mA,2min/床位)的图像质量(如均匀性、噪声、视觉评价)的差别.此外,通过模拟不同呼吸周期探讨其与辐射剂量间的关系。结果 1个PET床位的低剂量RG PET/CT的有效吸收剂量可降至4.88~7.69mSv[平均(5.68±0.83) mSv],且其PET图像信噪比与常规剂量时相比无明显差异,低剂量CT图像的均匀性在可接受范围(<5 HU),噪声较高,视觉评价肺结节特性在某些时相优于常规剂量CT。受检者的呼吸周期与辐射剂量呈正相关。结论 基于30 mA管电流、6个呼吸时相、1 min/时相、平静呼吸下的RG PET/CT的图像质量能满足肺结节特性观测及肿瘤放疗生物靶区勾画等临床应用,且辐射剂量大幅减低。
Abstract:
Objective To establish a low-dose but image-comparable respiratory-gated PET/CT (RG PET/CT) protocol based on 30 mA tube current plus other improved scanning parameters, such as the tube current, the number of respiratory phase and length of breathing cycle.Methods Twenty-six patients with 18F-FDG-intaking lung nodules underwent one-bed standard-dose PET/CT(120 mA, 2 min/bed)and lowdose RG PET/CT (30 mA, 6 respiratory phases, 1min/phase).The radiation dose and image quality were analyzed subsequently with signal to noise ratio (SNR)for PET and the homogeneity, noise level for CT in the water phantom respectively.Otherwise the CT images were both visual evaluated by two experienced doctors.In addition, different respiratory cycle was simulated to observe its relation with radiation dose.Results The effective dose of low-dose RG PET/CT was 4.88~7.69 mSv [mean (5.68±0.83) mSv].The PET SNR showed no significance between groups.The homogeneity of 30 mA is good (< 5 HU), although noise level was high, the visual character like lobulation, speculation of lung nodule was superior in some respiratory phases.The radiation dose was positively correlated with respiratory cycle.Conclusions The performance of low-dose RG PET/CT was comparable to those of standard-dose PET/CT based on a protocol with 30 mA tube current, 6 respiratory phases and breathing state of eupnoea.It produced a much lower radiation exposure and the image quality was enough for clinical use such as delineation of tumor active target, characterization and staging of lung nodules, etc.

参考文献/References:

[1] Guerra L, De Ponti E, Elisei F, et al. Respiratory gated PET/CT in a European multicentre retrospective study:added diagnostic value in detection and characterization of lung lesions. Eur J Nucl Med Mol Imaging, 2012, 39(9):1381-1390.
[2] van Elmpt W, Hamill J, Jones J, et al. Optimal gating compared to 3D and 4D PET reconstruction for characterization of lung tumours.Eur J Nucl Med Mol Imaging, 2011, 38(5):843-855.
[3] Prokop M. Radiation dose in computed tomography. Risks and challenges. Radiology, 2008, 48(3):229-242.
[4] Cohen MD. Pediatric CT radiation dose:how low can you go?. AJR Am J Roentgenol, 2009, 192(5):1292-1303.
[5] McCollough CH, Primak AN, Braun N, et al. Strategies for reducing radiation dose in CT. Radiol Clin North Am, 2009, 47(1):27-40.
[6] 武志芳,李思进,刘建忠,等.呼吸门控PET/CT对肺部结节SUV的影响.中华核医学与分子影像杂志,2012,32(2):111-114.
[7] 樊卫,张伟光,杨小春.PET/CT呼吸门控技术及其应用介绍.中华核医学杂志,2007,27(2):126-128.
[8] Li T, Schreibmann E, Thorndyke B, et al. Radiation dose reduction in four-dimensional computed tomography. Med Phys, 2005, 32(12):3650-3660.
[9] Hara R, Itami J, Kondo T, et al. Stereotactic single high dose irradi-ation of lung tumors under respiratory gating. Radiother Oncol,2002,63(2):159-163.
[10] Pan T, Mawlawi 0,Nehmeh SA, et al. Attenuation correction of PET images with respiration-averaged CT images in PET/CT. J Nucl Med, 2005,40:1481-1487.
[11] 北京市计量科学研究所,首都医科大学医学仪器质量控制技术研究中心.JJG 961-2001医用诊断计算机断层摄影装置(CT)X射线辐射源检定规程.北京:中国计量出版社,2001.
[12] Chang G, Chang T, Pan T, et al. Implementation of an automated respiratory amplitude gating technique for PET/CT:clinical evalu-ation. J Nucl Med, 2010,51(1):16-24.
[13] Lamb JM, Robinson C, Bradley J, et al. Generating lung tumor in-ternal target volumes from 4D-PET maximum intensity projections.Med Phys, 2011,38(10):5732-5737.
[14] Kasuya T, Tateishi U, Suzuki K, et al. Role of respiratory-gated PET/CT for pancreatic tumors:a preliminary result. Eur J Radiol,2013, 82(1):69-74.
[15] Suenaga Y, Kitajima K, Aoki H, et al. Respiratory-gated 18F-FDG PET/CT for the diagnosis of liver metastasis. Eur J Radiol, 2013, 82(10):1696-1701.
[16] Wu A, Zheng H, Kraenzle J, et al. Ferret thoracic anatomy by 2-deoxy-2-(18F)fluoro-D-glucose(18F-FDG) positron emission tomog-raphy/computed tomography (18F-FDG PET/CT) imaging. ILAR J,2012, 53(1):9-21.
[17] 黎喜,谢增海,罗慧.低剂量(30mA)胸部螺旋CT扫描的效果观察.广东医学院学报,2006,24(1):39-40.
[18] 孔秋雁,陈廷港,许崇永,等.多排螺旋CT低剂量扫描在小儿胸部的应用.实用放射学杂志,2007,23(6):792-794.
[19] 殷瑞根,王冬青,赵亮,等.多层螺旋CT肺部低剂量扫描的参数优化.实用放射学杂志,2004,20(8):694-697.
[20] Karabulut N, Törü M, Gelebek Y, et al. Comparison of low-dose and standard-dose helical CT in the evaluation of pulmonary nodules.Eur Radiol, 2002, 12(11):2764-2769.
[21] Zhu X, Yu J, Huang Z. Low-dose chest CT:optimizing radiation protection for patients. AJR Am J Roentgenol, 2004, 183(3):809-816.
[22] Wormanns D, Ludwig K, Beyer F, et al. Detection of pulmonary nodules at multirow-detector CT:effectiveness of double reading to improve sensitivity at standard-dose and low-dose chest CT. Eur Radiol, 2005, 15(1):14-22.
[23] Das M, Miihlenbruch G, Heinen S, et al. Performance evaluation of a computer-aided detection algorithm for solid pulmonary nodules in low-dose and standard-dose MDCT chest examinations and its influence on radiologists. Br J Radiol, 2008, 81(971):841-847.
[24] Christe A, Torrente JC, Lin M, et al. CT Screening and follow-up of lung nodules:effects of tube current-time setting and nodule size and density on detectability and of tube current-time setting on apparent size. AJR Am J Roentgenol, 2011, 197(3):623-630.
[25] Zhu Zhiyu, Tsui BMW, Segars WP. A Simulation Study of the Effect of Gating Scheme on respiratory Motion Blurring in FDG lung PET. IEEE Transactions on Nuclear Science, 2003, 13(3):1554-1558.
[26] 黄明刚,郭佑民,郑桂芳,等.早期肺癌低剂量CT检测的技术优化与应用.实用放射学杂志,2011,27(8):1263-1268.
[27] 刘彬,白玫.64层螺旋CT检查中患者受照剂量的研究.中华放射学杂志,2008,42(10):1050-1052.

相似文献/References:

[1]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
　He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[2]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
　Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[3]胡伟,赵军.小胶质细胞在AD炎性机制中的作用及其常见PET显像剂的应用进展[J].国际放射医学核医学杂志,2016,40(1):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
　Hu Wei,Zhao Jun.Microglia’s Alzheimer disease inflammatory mechanisms and progress of its common application in PET imaging agents[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
[4]张莹莹,王振光,孔艳.PET/CT显像在肺间质纤维化中的应用进展[J].国际放射医学核医学杂志,2016,40(1):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
　Zhang Yingying,Wang Zhenguang,Kong Yan.Application advancement on PET/CT in pulmonary interstitial fibrosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
[5]李海峰,张晓军,李云钢,等.国产模块LOOP环改良法合成11C-蛋氨酸[J].国际放射医学核医学杂志,2016,40(2):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
　Li Haifeng,Zhang Xiaojun,Li Yungang,et al.Synthesis of 11C-methionine on home-made module by the improved LOOP method[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
[6]史文杰,孟召伟,谭建.基于Deauville标准探讨18F-FDG PET/CT在霍奇金淋巴瘤复发诊断中的应用价值[J].国际放射医学核医学杂志,2016,40(2):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
　Shi Wenjie,Meng Zhaowei,Tan Jian.Value of 18F-FDG PET/CT on diagnosis of Hodgkin lymphoma recurrence using Deauville criterion[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
[7]李海峰,张晓军,张锦明.多巴胺转运蛋白显像剂11C-β-CFT在帕金森病中的应用研究[J].国际放射医学核医学杂志,2016,40(3):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
　Li Haifeng,Zhang Xiaojun,Zhang Jinming.Review of the use of dopamine transporter imaging agent 11C-β-CFT for diagnosing Parkinson disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
[8]尤阳,轩昂,张杰,等.淋巴瘤患者大脑静息葡萄糖代谢改变[J].国际放射医学核医学杂志,2016,40(4):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
　You Yang,Xuan Ang,Zhang Jie,et al.Changes in resting-state brain glucose metabolism in patients with lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
[9]邓大平,卢峰,孙洪强,等.颅脑肿瘤放射治疗时射野外器官吸收剂量体模法测量与分析[J].国际放射医学核医学杂志,2016,40(4):272.[doi:10.3760/cma.j.issn.1673-4114.2016.04.007]
　Deng Daping,Lu Feng,Sun Hongqiang,et al.Test and analysis of out-of-field organ dose in intracranial tumor radiotherapy using phantom[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):272.[doi:10.3760/cma.j.issn.1673-4114.2016.04.007]
[10]王朋,崔邦平,代文莉,等.18F-FDG PET/CT在前列腺癌中的应用进展[J].国际放射医学核医学杂志,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
　Wang Peng,Cui Bangping,Dai Wenli,et al.Progress in the application of 18F-FDG PET/CT in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
[11]赵檬,陈世容,程祝忠,等.铅屏风在PET增强CT中的具体应用及操作人员所受辐射剂量分析[J].国际放射医学核医学杂志,2017,41(1):29.[doi:10.3760/cma.j.issn.1673-4114.2017.01.006]
　Zhao Meng,Chen Shirong,Cheng Zhuzhong,et al.Application of lead screen in PET-enhanced CT scanning and radiation analysis on operator[J].International Journal of Radiation Medicine and Nuclear Medicine,2017,41(5):29.[doi:10.3760/cma.j.issn.1673-4114.2017.01.006]

备注/Memo

备注/Memo:
收稿日期:2013-07-02。
基金项目:山西省科技攻关项目(20120321028-03)
通讯作者:武志芳,Email:wuzhifang01@sina.com
更新日期/Last Update: 1900-01-01