[1]沈秀,刘晓秋,周则卫,等.昆明-无毛小鼠生物学特性的研究[J].国际放射医学核医学杂志,2013,37(2):74-76,87.[doi:10.3760/cma.j.issn.1673-4114.2013.02.003]
　SHEN Xiu,LIU Xiao-qiu,ZHOU Ze-wei,et al.Biological characteristic of Kunming-hairless mice[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):74-76,87.[doi:10.3760/cma.j.issn.1673-4114.2013.02.003]
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昆明-无毛小鼠生物学特性的研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第2期
页码:
74-76,87
栏目:
论著
出版日期:
2013-03-25

文章信息/Info

Title:
Biological characteristic of Kunming-hairless mice
作者:
沈秀;  刘晓秋;  周则卫;  杨福军;  张晓东;  龙伟;  王浩;  洪阁;  徐文清
中国医学科学院放射医学研究所, 天津市分子核医学重点实验室, 天津, 300192
Author(s):
SHEN Xiu;  LIU Xiao-qiu;  ZHOU Ze-wei;  YANG Fu-jun;  ZHANG Xiao-dong;  LONG Wei;  WANG Hao;  HONG Ge;  XU Wen-qing
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin
关键词:
肝肿瘤; 实验性; 白血病L1210; 昆明-无毛小鼠; 昆明小鼠
Keywords:
Liver neoplasms; experimental; Leukemia L1210; Kunming-Hairless mice; Kunming mice
DOI:
10.3760/cma.j.issn.1673-4114.2013.02.003
摘要:
目的 观察新品系昆明-无毛小鼠在正常、照射及接种肿瘤情况下的生物学指标。方法 ①测定正常昆明小鼠和正常昆明-无毛小鼠的各项生理指标;②将昆明小鼠和昆明-无毛小鼠同时接种上肿瘤(肝癌H22、白血病L1210),观察其生长情况;③昆明小鼠和昆明-无毛小鼠接受137Cs源γ射线照射后,观察白细胞、胸腺系数、脾系数等各项生理指标。结果 昆明小鼠与昆明-无毛小鼠正常指标之间无显着差异,只是昆明-无毛小鼠的胸腺略小一些;昆明-无毛小鼠和昆明小鼠接种上两种肿瘤后,肿瘤生长情况均较好;昆明小鼠和昆明-无毛小鼠接受137Cs源γ射线照射后,白细胞计数、胸腺系数、脾系数等各项生理指标均明显下降。结论 作为纯系小鼠的昆明-无毛小鼠具备昆明小鼠的生物学特性,可应用于科学实验研究。
Abstract:
Objective To observe the biological parameters of the new strain Kunming-hairless mice on the condition of normal,irradiation and tumor-implanting.Methods ①The physiological parameters of normal Kunming mice and normal Kunming-hairless mice were observed.②After being inoculated with hepatic carcinoma H22,leukemia L1210,tumor growth of the two kinds of mice was observed.③White blood cell count,thymus index and spleen index parameters were observed after irradiation by 137Cs γ-ray.Results The differences of normal parameters between Kunming mice and Kunming-hairless mice were not significant,but the immune parameter-thymuses of Kunming-hairless mice were smaller than that of Kunming mice,tumors growth after implantation were quite well in both strain Kunming and Kunming-hairless mice.Conclusion As pure strain animal,Kunming-hairless mice possesses biological traits of Kunming mice,it can be applied to the sciences experiment.

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备注/Memo

备注/Memo:
收稿日期:2012-07-20。
基金项目:天津市科技发展计划项目(项目编号:05YFGPGX07200)
通讯作者:徐文清,Email:xuwenqing67@yahoo.com.cn
更新日期/Last Update: 1900-01-01