[1]濮伟刚,谭纪伏,朱建华,等.血浆中四种肿瘤标志物和13C-尿素呼气试验对胃癌诊断的对比研究[J].国际放射医学核医学杂志,2010,34(2):94-96,104.[doi:10.3760/cma.j.issn.1673-4114.2010.02.008]
　PU Wei-gang,TAN Ji-fu,ZHU Jian-hua,et al.Clinical application of four plasma tumor markers and 13C-urea breath test in diagnosis of patients with gastric carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(2):94-96,104.[doi:10.3760/cma.j.issn.1673-4114.2010.02.008]
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血浆中四种肿瘤标志物和13C-尿素呼气试验对胃癌诊断的对比研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第2期
页码:
94-96,104
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Clinical application of four plasma tumor markers and 13C-urea breath test in diagnosis of patients with gastric carcinoma
作者:
濮伟刚1;  谭纪伏1;  朱建华1;  杨永青2
1. 南京医科大学附属苏州医院普外科, 苏州, 215002;
2. 南京医科大学附属苏州医院核医学科, 苏州, 215002
Author(s):
PU Wei-gang1;  TAN Ji-fu1;  ZHU Jian-hua1;  YANG Yong-qing2
Department of General Surgery, Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
关键词:
胃肿瘤; 胃泌素类; 瘦素; CA-125抗原; 抗原; 肿瘤相关; 碳水化合物; 螺杆菌; 幽门; 放射免疫测定
Keywords:
Stomach neoplasms; Gastrin; Leptin; CA125 antigen; Antigen; tumor-associated; carbohydrate; Helicobacter; pylori; Radioimmunoassay
DOI:
10.3760/cma.j.issn.1673-4114.2010.02.008
摘要:
目的 探讨胃癌患者血浆中胃泌素、瘦素、糖类抗原125(CA125)、糖类抗原72-4(CA72-4)水平和13C-尿素呼气试验(13C-UBT)对胃癌诊断的对比研究。方法 采用放射免疫分析法、酶免疫吸附测定法测定126例胃癌患者(其中Ⅰ~Ⅱ期32例、Ⅲ期57例和Ⅳ期37例)和60名正常对照者血浆中胃泌素、瘦素、CA125和CA72-4水平;用13C-UBT测定幽门螺旋杆菌(HP)感染的阳性率并进行比较性分析。结果 126例胃癌患者血浆中的胃泌素、CA125和CA72-4水平较60名正常对照者均明显升高(t分别为3.125、3.519、3.788,P均<0.01),并随疾病的严重程度而增加;血浆瘦素水平较60名正常对照者明显降低(t=3.524,P<0.01),并随疾病的严重程度不断减少。与正常对照组相比,4种肿瘤标志物中CA72-4水平变化最明显。126例胃癌患者HP感染的阳性率为84.9%,其中,Ⅰ~Ⅱ期、Ⅲ期和Ⅳ期胃癌患者HP感染的阳性率分别为46.9%、89.5%和89.2%;60名正常对照者HP感染的阳性率为15.0%。结论 通过对126例胃癌患者血浆中胃泌素、瘦素、CA125和CA72-4水平的分析表明,血浆中的CA72-4水平诊断胃癌为最佳,其次为瘦素、CA125及胃泌素。因胃癌与HP的关系密切,故尽早使用13C-UBT测定HP感染和治疗HP感染者甚为重要。
Abstract:
Objective To investigate clinical value of plasma gastrin, leptin, carbohydrate antigen 125(CA125), carbohydrate antigen 72-4(CA72-4) and 13C-urea breath test(13C-UBT) in diagnosis of patients with gastric carcinoma. Methods Radioimmunoassay and enzyme immunosorbent assay were used to deter-mine the plasma gastrin, leptin, CA125 and CA72-4 levels, and helicobacter pylori(HP) infection rate was determined by 13C-UBT. Compared all the determined results from 126 patients with gastric carcinoma(in-cluding 32 cases I-II stage gastric carcinoma, 57 cases III stage gastric carcinoma and 37 cases IV stage gastric carcinoma) and 60 normal controls. Results The plasma gastrin, CA125 and CA72-4 levels in 126 patients with gastric carcinoma were significantly higher(t=3.125, t=3.519, t=3.788, P<0.01) but plasma level was significantly lower(t=3.524, P<0.01) than those in 60 normal controls. Compared with normel controls, the result of CA72-4 was signeficantly changed. The plasma gastrin, CA125 and CA72-4 levels in 126 patients with gastric carcinoma were increased with the severity of gastric carcinoma, but plasma leptin was decreased.The HP infection rate in 126 patients with gastric carcinoma(84.9%) were significantly higher than those in 60 normal controls(15%). The HP infection rate in 32 Ⅰ~Ⅱ, 57 Ⅲ and 37 Ⅳ stage gastric carcinoma were 46.9%, 89.5% and 89.2% respectively and were increased with severity of gastric carcinoma. Conclusion The determination of plasma CA72-4 was the best item for diagnosis of gastric carcinoma in four tumor markers, leptin, CA125 and gastrin followed. The determination of HP infection rate in gastric carcinoma by 13C-UBT played a considerable role for diagnosis and therapy.

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备注/Memo

备注/Memo:
收稿日期:2010-01-28。
通讯作者:杨永青(E-mail:spl208@163.com)
更新日期/Last Update: 1900-01-01