[1]胡红永,汤建林,李玉莹,等.肿瘤标志物CEA、CA19-9、CA242联检在结直肠癌患者诊断中的应用[J].国际放射医学核医学杂志,2010,34(2):97-99.[doi:10.3760/cma.j.issn.1673-4114.2010.02.009]
　HU Hong-yong,TANG Jian-lin,LI Yu-ying,et al.The value of combined tumor markers of CEA, CA19-9 and CA242 for diagnosis of patients with colorectal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(2):97-99.[doi:10.3760/cma.j.issn.1673-4114.2010.02.009]
点击复制

肿瘤标志物CEA、CA19-9、CA242联检在结直肠癌患者诊断中的应用(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第2期
页码:
97-99
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The value of combined tumor markers of CEA, CA19-9 and CA242 for diagnosis of patients with colorectal cancer
作者:
胡红永;  汤建林;  李玉莹;  高柳燕;  唐秀萍
云南省大理州人民医院核医学科, 大理, 671000
Author(s):
HU Hong-yong;  TANG Jian-lin;  LI Yu-ying;  GAO Liu-yan;  TANG Xiu-ping
Department of Nuclear Medicine, The People’s Hospital of Dali, Dali 671000, China
关键词:
结直肠肿瘤; 癌胚抗原; CA-19-9抗原; CA-242抗原; 放射免疫测定
Keywords:
Colorectal neoplasms; Carcinoembryonic antigen; CA-19-9 antigen; CA-242 antigen; Radioimmunoassay
DOI:
10.3760/cma.j.issn.1673-4114.2010.02.009
摘要:
目的 探讨云南省大理州结直肠癌患者血清中肿瘤标志物癌胚抗原(CEA)、糖链蛋白抗原19-9(CA19-9)、糖链蛋白抗原242(CA242)单项或多项联检对结直肠癌的临床诊断价值。方法 应用电化学发光法和放免法检测89例结直肠癌患者和50例正常体检者的CEA、CA19-9和CA242水平。结果 三种肿瘤标志物在结直肠癌患者血清中含量均明显高于健康对照组(t分别为2.97、3.55和7.44,P均<0.01);三种肿瘤标志物联检对结直肠癌的临床诊断效果明显优于各单项(CEA、CA19-9、CA242)和两项联检(CA242+CA19-9和CEA+CA19-9),差异有统计学意义(χ2分别为30.552、32.076、18.365、7.130和8.862,P均<0.01);三项联检可提高结直肠癌诊断的灵敏度(85.39%)和准确率(90.60%),但特异度下降(88.00%).结论 CEA、CA19-9和CA242可用于该地区结直肠痛的早期诊断和病情判断,三者联检可提高诊断效率。
Abstract:
Objective To explore the clinical value of serum tumor markers carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9) and carbohydrate antigen 242(CA242) levels in patients with colorectal cancer using single item and multi-items determination. Methods Serum levels of CEA, CA19-9 and CA242 were measured with chemiuminescent immunoassay(CLIA) and radioimmunoassay(RIA) in 89 cases of colorectal cancer patients and 50 cases of normal people. Results The serum levels of this three tumor markers were significantly higher than those in the control group(t=2.97, 3.55 and 7.44, P<0.01). Combined determination of those three obviously excels that two items(CA242+CA19-9 and CEA+CA19-9) or single item, there was statistical significance(χ2=30.552, 32.076, 18.365, 7.130 and 8.862, P<0.01). Combined determination of those three could enhance the sensitivity(85.39%) and accuracy(90.60%), but the specificity was decreased(88.00%). Conclusion Determination of serum CEA, CA19-9 and CA242 levels are valuable for the diagnosis and evaluation of patients with colorectal cancer, and the diagnosis sensitivity can be enhanced with combined determinations.

参考文献/References:

[1] 胡水清,汤哲,张玫.结直肠癌患病的糖尿病相关因素研究.中国老年学杂志,2008,28(3):253-255.
[2] 陈创,陈利琴,杨国梁,等.肿瘤标志物在结直肠痛诊断和监测中的价值和改进策略:130例患者的临床资料分析.癌症,2007,26(11):1221-1226.
[3] 朱玉琨,翟良,袁荣国,等.大肠癌患者血清CA242、CA19-9和CEA水平测定的临床意义.肿瘤研究与临床,2004,16(4):227-229.
[4] Seregni E,Coli A,Mazzucca N,et al.Circulating tumor markers in breast cancer.Eur J Nucl Med Mol Imaging,2004,31(suppl 1):S15-S22.
[5] Chen CC,Yang SH,Lin JK,et al.Is it reasonable to add preoperative serum level of CEA and CA19-9 to staging for colorectal cancer?.J Surg Res,2005,124(2):169-174.
[6] 尹伯元.标记免疫分析临床应用手册.1版.北京:原子能出版社,1994:11,45.
[7] Carpelan-Holmstrom M,Louhimo J,Stenman UH,et al.CEA,CA19-9 and CA72-4 improve the diagnostic accuracy in gastrointestinal cancers.Anticancer Res,2002,22(4):2311-2316.
[8] 赵明,田爱娟,张宏伟,等.结直肠癌患者血清CA19-9、CA242和CEA检测的临床意义.放射免疫学杂志,2008,21(4):323-324
[9] 王影,梁欢.血清CEA、CA199、CA424联检在大肠癌诊断中的临床应用.中国卫生检验杂志,2008,18(7):1359-1360.

相似文献/References:

[1]黄天骄,史学森,孙凯.CT虚拟结肠镜对早期筛查结直肠癌的研究进展[J].国际放射医学核医学杂志,2016,40(6):474.[doi:10.3760/cma.j.issn.1673-4114.2016.06.014]
　Huang Tianjiao,Shi Xuesen,Sun Kai.Research progress of CT virtual colonoscopy for early screening of colorectal neoplasmas[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):474.[doi:10.3760/cma.j.issn.1673-4114.2016.06.014]
[2]马佶赟,石洪成.PET-CT在结直肠癌肝转移诊治中的应用进展[J].国际放射医学核医学杂志,2010,34(4):212.[doi:10.3760/cma.j.issn.1673-4114.2010.04.006]
　MA Ji-yun,SHI Hong-cheng.Progress in application of PET-CT in diagnosis and therapy of liver metastasis from colorectal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(2):212.[doi:10.3760/cma.j.issn.1673-4114.2010.04.006]
[3]路宝士,高玉芳.血清CA15-3、CEA检测联合全身骨显像在乳腺癌骨转移中的诊断价值[J].国际放射医学核医学杂志,2011,35(2):107.[doi:10.3760/cma.j.issn.1673-4114.2011.02.010]
　LU Bao-shi,GAO Yu-fang.The value of combined examination of serum CA15-3, CEA level and whole body bone scan in the diagnosis of bone metastasis in breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(2):107.[doi:10.3760/cma.j.issn.1673-4114.2011.02.010]
[4]袁超,陶健,袁媛,等.血清CA15-3、CEA及全身骨显像联合检查对乳腺癌骨转移的诊断价值[J].国际放射医学核医学杂志,2009,33(6):353.[doi:10.3760/cma.j.issn.1673-4114.2009.06.011]
　YUAN Chao,TAO Jian,YUAN Yuan,et al.The diagnostic significance of CA15-3, CEA combined with whole body bone scan for bone metastases in patients with breast cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):353.[doi:10.3760/cma.j.issn.1673-4114.2009.06.011]
[5]张悦.18F-氟脱氧葡萄糖PET和PET-CT在结直肠癌术后复发或转移中的应用价值[J].国际放射医学核医学杂志,2007,31(1):34.
　ZHANG Yue.The value of 18F-fluorodeoxyglucose PET and PET-CT in the detection of recurrence and metastases of colorectal cancer post-operation[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):34.
[6]渠浩,王振军,陈大志,等.18F-氟代脱氧葡萄糖正电子放射导向手术在结直肠癌治疗中的初步应用[J].国际放射医学核医学杂志,2006,30(3):145.
　QU Hao,WANG Zhen-jun,CHEN Da-zhi,et al.The preliminary study using 18F-fluorodeoxyglucose positron-radioguided surgery for colorectal carcinoma operation[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):145.
[7]杜忠斌,武春梅,李润,等.凝聚胺法放射免疫快速测定癌胚抗原的应用[J].国际放射医学核医学杂志,2006,30(5):296.
　DU Zhong-bin,WU Chun-mei,LI Run,et al.Application of polybrene in rapid radioimmunoassay carcinoembryonic antigen[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):296.
[8]罗全勇.基因转染诱导核素靶向治疗的实验研究[J].国际放射医学核医学杂志,2001,25(2):60.
　LUO Quan-yong.Inducement of radionuclides targeting therapy by gene transfection[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(2):60.
[9]田蓉蓉,薄云峰,张毅勋,等.18F-FDG PET/CT显像与结直肠癌治疗前分期的相关性研究[J].国际放射医学核医学杂志,2018,(1):9.[doi:10.3760/cma.j.issn.1673-4114.2018.01.002]
　Tian Rong-rong,Bo Yunfeng,Zhang Yixun,et al.Correlation between 18F-FDG PET/CT and pretreatment staging of colorectal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(2):9.[doi:10.3760/cma.j.issn.1673-4114.2018.01.002]
[10]孙斌,刘举珍,张飞飞.SPECT/CT断层融合显像联合血清CEA、CYFRA21-1在诊断非小细胞肺癌骨转移中的应用[J].国际放射医学核医学杂志,2018,(3):212.[doi:10.3760/cma.j.issn.1673-4114.2018.03.004]
　Sun Bin,Liu Juzhen,Zhang Feifei.Application of SPECT/CT tomographic fusion imaging combined with serum CEA and CYFRA21-1 in the diagnosis of bone metastasis of non-small cell lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(2):212.[doi:10.3760/cma.j.issn.1673-4114.2018.03.004]

备注/Memo

备注/Memo:
收稿日期:2009-11-15。
通讯作者:胡红永(E-mail:hhyhuhongyong@126.com)
更新日期/Last Update: 1900-01-01