[1]王长修.碳酸锂在低摄131I率Graves病患者131I治疗中的应用价值[J].国际放射医学核医学杂志,2010,34(2):100-101.[doi:10.3760/cma.j.issn.1673-4114.2010.02.010]
　WANG Chang-xiu.Application value of lithium carbonate for the low uptake rate of 131I treatment in patients with Graves[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(2):100-101.[doi:10.3760/cma.j.issn.1673-4114.2010.02.010]
点击复制

碳酸锂在低摄131I率Graves病患者131I治疗中的应用价值(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第2期
页码:
100-101
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Application value of lithium carbonate for the low uptake rate of 131I treatment in patients with Graves
作者:
王长修
河北省邢台市人民医院核医学科, 054031
Author(s):
WANG Chang-xiu
Department of Nuclear Medicine, The People’s Hospital of Xingtai, Hebei Xingtai 054031, China
关键词:
格雷夫斯病; 碳酸锂; 甲状腺; 碘放射性同位素
Keywords:
Graves disease; Lithium carbonate; Thyroid; Iodine radioisotopes
DOI:
10.3760/cma.j.issn.1673-4114.2010.02.010
摘要:
目的 通过对Graves病患者服用碳酸锂后甲状腺摄131I率变化的观察,探讨碳酸锂在低摄131I率Graves病患者131I治疗中的应用价值。方法 46例摄131I率低的Graves病患者口服碳酸锂,每日3次,每次250 mg,餐后服用,连续服用10 d,分别在用药前、后进行甲状腺摄131I率的测定,并比较用药前后差别。结果 46例摄131I率低的Graves病患者在服用碳酸锂10 d后甲状腺的24 h摄131I率比服用前明显升高(27%),两者具有统计学差异(t=3.24,P<0.01)。结论 碳酸锂能够提高Graves病患者的甲状腺摄131I率,达到了患者要求并减少了131I的治疗用量,具有实用推广价值。
Abstract:
Objective To observe 131I uptake rate of Graves’s patients after taking lithium carbonate thyroid and to investigate application value of lithium carbonate for the low 131I uptake rate in Graves’s patients. Methods Forty-six low 131I uptake Graves’s patients take lithium carbonate orally after meal, three times daily, 250 mg each time, and served 10 days, detected 131I uptake rate respectively before and after lithium carbonate treatment and compared the changes. Result Low 131I uptake rate after intake of lithium carbonate with 10 days was significantly higher(27%) in 24 hours than before with a statistic difference(t=3.24, P<0.01). Conclusions Lithium carbonate can improved the intake of thyroid 131I Graves’s patients, met the requirements of patients and reduced the amount of 131I treatment. So it was valuable for clinical application.

参考文献/References:

[1] Koong SS,Reynolds JC,Movius EG,et al.Lithium as a potential adjuvant to 131I therapy of metastatic,well differentiated thyroid carci-noma.J Clin Endocrinol Metab,1999,84(3):912-916.
[2] 康玉国.匡安仁,陈淼.碳酸锂在131I治疗Graves病中的应用.同位素,2004,17(1):59-61.
[3] 张承刚.甲状腺疾病核素治疗学.北京:原子能出版社,2003:181.
[4] Bogazzi F,Bartalena U Brogioni S,et al.Comparison of radioiodine with radioiodine plus lithium in the treatment of Graves’ hyperthy-roidism.J Clin Endocrinol Metab,1999,84(2):499-503.

相似文献/References:

[1]梁雯丽,郑艳,李娜,等.Graves甲亢患者131I治疗后早期TRAb及TSAb变化的研究分析[J].国际放射医学核医学杂志,2016,40(1):13.[doi:10.3760/cma.j.issn.1673-4114.2016.01.003]
　Liang Wenli,Zheng Yan,Li Na,et al.Analysis of the changes in early TRAb and TSAb after 131I treatment for patients with Graves hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):13.[doi:10.3760/cma.j.issn.1673-4114.2016.01.003]
[2]田琦,蒋宁一,郑丽.265例精细个体化131I治疗Graves甲亢的疗效观察[J].国际放射医学核医学杂志,2016,40(4):259.[doi:10.3760/cma.j.issn.1673-4114.2016.04.004]
　Tian Qi,Jiang Ningyi,Zheng Li.Therapeutic effect of fine individual 131I treatment on Graves disease hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(2):259.[doi:10.3760/cma.j.issn.1673-4114.2016.04.004]
[3]王越,晋建华,李思进,等.甲状腺24h摄碘率与131I治疗Graves甲亢疗效相关性研究[J].国际放射医学核医学杂志,2015,39(6):442.[doi:10.3760/cma.j.issn.1673-4114.2015.06.002]
　Wang Yue,Jin Jianhua,Li Sijin,et al.Correlation between thyroid 24 h of radioactive iodine uptake and clinical efficacy of 131I therapy for Graves’ hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):442.[doi:10.3760/cma.j.issn.1673-4114.2015.06.002]
[4]张丽花,蒋宁一.131I治疗Graves甲亢合并肝功能损害或血细胞减少的优势与风险[J].国际放射医学核医学杂志,2015,39(6):483.[doi:10.3760/cma.j.issn.1673-4114.2015.06.010]
　Zhang Lihua,Jiang Ningyi.The advantage and risk of 131I treatment in hyperthyroidism combined with liver injury or blood cell reduction[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):483.[doi:10.3760/cma.j.issn.1673-4114.2015.06.010]
[5]胡小春,蒋宁一,李敬彦,等.硒对经131I治疗Graves病患者血清甲状腺过氧化物酶抗体水平的影响[J].国际放射医学核医学杂志,2015,39(2):140.[doi:10.3760/cma.j.issn.1673-4114.2015.02.008]
　Hu Xiaochun,Jiang Ningyi,Li Jingyan,et al.Effect of additional selenium on the levels of serum thyroid peroxidase antibody in patients with Graves disease treated with 131I[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(2):140.[doi:10.3760/cma.j.issn.1673-4114.2015.02.008]
[6]俞秀华,黄炜坤,林玉梅.131I治疗Graves病合并肝损害的临床观察[J].国际放射医学核医学杂志,2014,38(2):90.[doi:10.3760/cma.j.issn.1673-4114.2014.02.005]
　Yu Xiuhua,Huang Weikun,Lin Yumei.Clinical observation of 131I therapy in Graves disease patients with hepatic dysfunction[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(2):90.[doi:10.3760/cma.j.issn.1673-4114.2014.02.005]
[7]王深,孟召伟,贾强,等.MRI弥散加权成像、甲状腺摄碘率和血清指标测定鉴别Graves甲状腺功能亢进症和无痛性甲状腺炎的研究[J].国际放射医学核医学杂志,2014,38(6):392.[doi:10.3760/cma.j.issn.1673-4114.2014.06.011]
　Wang Shen,Meng Zhao-wei,Jia Qiang,et al.Differentiation between Graves disease and painless thyroiditis by diffusion-weighted imaging, thyroid radioactive iodine uptake and serum parameters measurement[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(2):392.[doi:10.3760/cma.j.issn.1673-4114.2014.06.011]
[8]郑艳,赵德善,付松海,等.儿童和青少年Graves甲亢患者131Ⅰ治疗剂量的分析研究[J].国际放射医学核医学杂志,2013,37(2):69.[doi:10.3760/cma.j.issn.1673-4114.2013.02.002]
　ZHENG Yan,ZHAO De-shan,FU Song-hai,et al.The dose analysis of 131Ⅰ treatment in pediatric patients with Graves hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):69.[doi:10.3760/cma.j.issn.1673-4114.2013.02.002]
[9]王朝点,史育红,颜兵.TRAb水平测定在Graves眼病中的临床意义探讨[J].国际放射医学核医学杂志,2013,37(2):77.[doi:10.3760/cma.j.issn.1673-4114.2013.02.004]
　WANG Chao-dian,SHI Yu-hong,YAN Bing.The clinical value of serum thyrotrophin receptor antibody level in patients with Graves ophthalmopathy[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):77.[doi:10.3760/cma.j.issn.1673-4114.2013.02.004]
[10]张瑞国,秦岚,张又萍,等.初诊Graves甲亢合并肝损害及其影响因素的临床分析[J].国际放射医学核医学杂志,2013,37(5):283.[doi:10.3760/cma.j.issn.1673-4114.2013.05.008]
　ZHANG Rui-guo,QIN Lan,ZHANG You-ping,et al.Clinical study of hepatic dysfunction and its correlative factors in newly diagnosed patients with Graves hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(2):283.[doi:10.3760/cma.j.issn.1673-4114.2013.05.008]
[11]查金顺,蒋艳,徐源,等.131I辅以短期小剂量碳酸锂治疗Graves甲亢的研究[J].国际放射医学核医学杂志,2014,38(1):10.[doi:10.3760/cma.j.issn 1673-4114.2014.01.003]
　Zha Jinshun,Jiang Yah,Xu Yuan,et al.Clinical research on radioiodine addition of low-doses of lithium carbonate in short-term treatment of Graves hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(2):10.[doi:10.3760/cma.j.issn 1673-4114.2014.01.003]
[12]查金顺,黄春玲,蒋婷吟,等.131I治疗Graves甲状腺功能亢进症中碳酸锂的应用[J].国际放射医学核医学杂志,2011,35(2):93.[doi:10.3760/cma.j.issn.1673-4114.2011.02.007]
　ZHA Jin-shun,HUANG Chun-ling,JIANG Ting-yin,et al.Application of lithium carbonate on radioiodine treatment of Graves’ hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(2):93.[doi:10.3760/cma.j.issn.1673-4114.2011.02.007]
[13]徐海青,吴边.131I合并小剂量碳酸锂治疗Graves病的临床探讨[J].国际放射医学核医学杂志,2006,30(3):151.
　XU Hai-qing,WU Bian.Clinical investigation of 131I therapy combined with low-dose lithium carbonate for Graves disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):151.

备注/Memo

备注/Memo:
收稿日期:2009-10-23。
更新日期/Last Update: 1900-01-01