[1]荆卫娟,杨永青.慢性萎缩性胃炎向胃癌转化时血清胃泌素和幽门螺杆菌的变化及其作用[J].国际放射医学核医学杂志,2009,33(6):341-343.[doi:10.3760/cma.j.issn.1673-4114.2009.06.006]
　JING Wei-juan,YANG Yong-qing.The changing and us interaction of determining serum gastrin levels and helicobacter pylori test during chronic atrophic gastritis into gastric cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(6):341-343.[doi:10.3760/cma.j.issn.1673-4114.2009.06.006]
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慢性萎缩性胃炎向胃癌转化时血清胃泌素和幽门螺杆菌的变化及其作用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第6期
页码:
341-343
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The changing and us interaction of determining serum gastrin levels and helicobacter pylori test during chronic atrophic gastritis into gastric cancer
作者:
荆卫娟1;  杨永青2
1. 苏州大学附属第一人民医院娄葑分院检验科, 苏州 215006;
2. 苏州市立医院核医学科, 苏州 215002
Author(s):
JING Wei-juan1;  YANG Yong-qing2
1. Department of Diagnosis, Loufeng Branch, the First Affiliated Hospital of Soochow University, Suzhou 215006, China;
2. Department of Nuclear Medicine, Suzhou municipal Hopital, Suzhou 215002, China
关键词:
胃炎; 萎缩性; 胃肿瘤; 胃泌素类; 螺杆菌; 幽门; 放射免疫测定; 13C-呼气试验
Keywords:
Gastritis; alrophix; Stomach neoplasms; Gastrins; Helicobacter pylori; Radioimmunoassay; 13C-urea breath test
DOI:
10.3760/cma.j.issn.1673-4114.2009.06.006
摘要:
目的 探讨慢性萎缩性胃炎(CAG)向胃癌转化时血清胃泌素(Gs)和幽门螺杆菌(Hp)的变化及其作用。方法 采用放射免疫分析和13C-尿素呼气试验(13C-UBT)检测了63例CAG(其中随访1年者48例、3年者35例和5年者30例)、90例胃癌和61例正常对照者血清Gs水平及Hp感染率,并做组间比较分析。结果 63例首诊CAG、48例随访1年CAG、35例随访3年CAG、30例随访5年CAG和90例胃癌者血清Gs水平明显高于正常对照组(t分别为4.716、5.218、5.624、6.179和6.572,均为P<0.01),Hp感染率分别为65.1%、70.8%、82.9%、86.7%和88.8%。90例不同部位胃癌患者血清Gs的水平:胃窦癌患者与正常对照组比较无统计学意义(t=1.560,P>0.05),胃体癌和胃底贲门癌患者正常对照组明显增加(t=4.221,P<0.05;t=4.436,P<0.01),以胃底贲门癌患者为最高。结论 CAG患者血清Gs水平和Hp感染率的随访测定可达到胃癌患者早期诊断和治疗之目的。
Abstract:
Objective To study the changing and its interaction of determining serum gastrin levels and Helicobacter pylori test during chronic atrophic gastritis into gastric cancer. Methods RIA and 13C-urea breath test(13C-UBT) determined the Gs levels and Hp infection rate in 63 rate cases(first visit) patients,48 cases(after one year return visit) patients, 35 cases(after three year return visit) patients and 30 cases(after five years return visit) patients with CAG 90 cases patients with gastric cancer(and different position) and 61 cases normal controls. They all were done study compared. Results Serum Gs levels in 63 cases(first visit) patients, 48 cases(after one year return visit) patients, 35 cases(after three year return visit) patients and 30 cases(after five years return visit) patient with CAG were significantly higher(t=4.716, 5.218,5.624, 6,179, 6,572, all P<0.01) than 61 cases normal controls, but Hp infection rate were 65,1%, 70,8%,82.9%, 86.7% and 88.8%. There was no distinct difference between serum Gs in patients with sinuses ventriculi cancer and normal controls(t=1.560, P>0.05). Serum Gs levels in 90 cases with gastric cancer(and different position) was significantly higher(t=4.221, P<0.05; t=4.436, P<0.01) than 61 cases normal controls and the highest serum Gs level was found in cancer of cardia and fundus. And Hp infection rate was 88.8%. Conclusion The early diagnosis on gastric cancer was very important by determining serum Gs and Hp infection rate.

参考文献/References:

[1] Kouturek PC,Kania J,Konturek J W,et al.H.pylori infection,atrophic gastritis,cytokines,gastrin,COX-2,PPAR gamma and impaired apoptosis in gastric carcinogenesis.Med Sci Monit,2003,9(7):SR53-SR66.
[2] 黄广建,余枫,王德昭.胃癌患者血清胃泌素水平的变化及其作用.上海医学,1999,22(1):36-37.
[3] Joh T,Kataoka H,Tanida S,et al.Helicobacter pylori-stimulated interleukin-8(IL-8)promotes cell proliferation through transactiv-ation of epidermal growth factor receptor (EGFR)by disintegrin and metalloproteimase (ADAM)activation.Dig Dis Sci,2005,50(11):2081-2089.
[4] 王建华,卢征义,谭毓铨,等.胃癌病人的胃泌素分泌.中华实验外科杂志,1996,13(3):149-151.
[5] 姜林明,潘晓峰.胃癌表达血清胃泌素的特征及意义.上海医学,2002,25(2):121-122.

相似文献/References:

[1]匡安仁,谭天秩,韩佩珍.14C-尿素呼吸试验诊断幽门螺杆菌感染[J].国际放射医学核医学杂志,1996,20(6):246.

备注/Memo

备注/Memo:
收稿日期:2009-09-22。
通讯作者:杨永青(E-mail:szjwj@163.com)
更新日期/Last Update: 1900-01-01