[1]刘刚,吴华,吴立兵,等.99Tcm-HL91 SPECT探测缺血存活心肌的初步应用研究[J].国际放射医学核医学杂志,2009,33(2):73-75.[doi:10.3760/cma.j.issn.1673-4114.2009.02.003]
　LIU Gang,WU Hua,WU Li-bin,et al.Preliminary assessment of ischemic and viable myocardium with 99Tcm-HL91 SPECT[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):73-75.[doi:10.3760/cma.j.issn.1673-4114.2009.02.003]
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99Tcm-HL91 SPECT探测缺血存活心肌的初步应用研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第2期
页码:
73-75
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Preliminary assessment of ischemic and viable myocardium with 99Tcm-HL91 SPECT
作者:
刘刚1;  吴华2;  吴立兵1;  李伏燕1;  裴之俊1;  陈宇1
1. 郧阳医学院附属太和医院核医学科, 湖北十堰 442000;
2. 福建医科大学附属厦门第一医院核医学科, 福建 361006
Author(s):
LIU Gang1;  WU Hua2;  WU Li-bin1;  LI Fu-yan1;  PEI Zhi-jun1;  CHEN Yu1
1. Department of Nuclear Medicine, Taihe Hospital, Yunyang Medical University, Hubei Shiyan, 442000, China;
2. Department of Nuclear Medicine, Xiamen First Hospital, Fujian Medical University, Fujian Xiamen 361006, China
关键词:
心肌; 体层摄影术; 发射型计算机; 单光子; 99m锝甲氧基异丁基异腈; 99Tcm-HL9l
Keywords:
Myocardium; Tomography;  emission-computed;  single-photon; Techonetium; Tc99m sestamibi 99Tcm-HL91
DOI:
10.3760/cma.j.issn.1673-4114.2009.02.003
摘要:
目的 研究99Tcm-4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮肟(99Tcm-HL91)在缺血心肌中的显像表现,探讨99Tcm-HL91探测缺血但存活心肌的价值.方法 18例已确诊为心肌缺血或心肌梗死的患者均行99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)与99Tcm-HL91心肌灌注显像.在心脏短轴图像上通过感兴趣区技术获取缺血区与正常心肌组织的平均放射性计数,获得99Tcm-MIBI与99Tcm-HL91在局部缺血区与正常心肌组织的放射性比值.结果 10例患者在99Tcm-MIBI显像的放射性稀疏或缺损区而在99Tcm-HL91 SPECT可见到明显的放射性充填;其余8例患者99Tcm-HL91显像心肌摄取不高.结论 99Tcm-HL91可选择性地被存活乏氧心肌摄取,与99Tcm-MIBI SPECT联合应用,可望有效提高检测存活心肌的效能.
Abstract:
Objective To investigate the image characteristic of 99Tcm-4, 9-diaza-3, 3, 10, 10-tetramethyldodecan-2, 11-dione dioxime (99Tcm-HL91) in the ischemic myocardium, thus explore the possibility of 99Tcm-HL91 in assessment of ischemic but viable myocardium. Methods Eighteen patients with cardiac infarction went 99Tcm-sestamibi(99Tcm-MIBI)SPECT and 99Tcm-HL91 SPECT. Average radioactivity of ischemic area and normal area were respectively obtained by region of interest on heart short axis images.The radioactivity ratios of target (ischemic area)-to-non target (normal area) were calculated. Results In 10 patients the positive 99Tcm-HL91 uptake was shown in the defect region of 99Tcm-MIBI images. In the other cases, similar signs have not been found. Conclusions 99Tcm-HL91 may be selectively uptaken by ischemic and hypoxic but viable myocardium. The combination of 99Tcm-MIBI and 99Tcm-HL91 SPECT may be more helpful for accurate evaluation of hypoxic viable myocardium.

参考文献/References:

[1] Pallister I, Iorwerth A. Indirect reduction using a simple quadrilateral frame in the application of distal tibial LCP-technical tips. Injury, 2005, 36(9):1138-1142.
[2] 刘生,王艺东,蒋宁一,等.99Tcm-HL91 SPECT显像检测急性脑梗死乏氧脑组织的研究.中华核医学杂志,2004,24(4):236-237.
[3] 侯妮,邹保民,胡国瑛,等.99Tcm-HL91在体外乏氧心肌细胞中的动力学观察.同位素,2002,15(3):151-153.
[4] 李艳,刘刚,李伏燕,等.99Tcm-HL91对大鼠心肌梗死再灌注后存活心肌的评价.郧阳医学院学报,2005,24(5):288-290.
[5] 李艳,刘刚,吴立兵,等.用99Tcm-HL91评价鼠心肌缺血模型.中华核医学杂志,2006,26(5):280-281.

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备注/Memo

备注/Memo:
收稿日期:2008-12-19。
通讯作者:吴华(E-mail:wuhuaa@hotmail.com)
更新日期/Last Update: 1900-01-01