[1]叶慧,莫逸,谢爱民,等.18F-氟脱氧葡萄糖PET-CT与99nTc-亚甲基二膦酸盐骨显像诊断转移性骨肿瘤的对比研究[J].国际放射医学核医学杂志,2008,32(3):147-150.
　YE Hui,MO Yi,XIE Ai-min,et al.Comparison study of 18F-fluorodeoxyglucose PET-CT and 99Tc-methylene phospho-nate bone scan in detecting bone metastases[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(3):147-150.
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18F-氟脱氧葡萄糖PET-CT与99nTc-亚甲基二膦酸盐骨显像诊断转移性骨肿瘤的对比研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第3期
页码:
147-150
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Comparison study of 18F-fluorodeoxyglucose PET-CT and 99Tc-methylene phospho-nate bone scan in detecting bone metastases
作者:
叶慧;  莫逸;  谢爱民;  彭翔
410013 长沙, 湖南省肿瘤医院PET-CT中心
Author(s):
YE Hui;  MO Yi;  XIE Ai-min;  PENG Xiang
PET-CT Center, Hunan Tumor Hospital, Changsha 410013, China
关键词:
骨肿瘤; 肿瘤转移; 氟脱氧葡萄糖F18; 99mTc-美罗酸盐; 体层摄影术; X线计算机; 体层摄影术; 发射型计算机; 对比研究
Keywords:
Bone neoplasms; Neoplasms metastasis; Fludeoxyglucose F18; 99mTc-medronate; Tomography; X-ray computed; Tomography; emission-computed; Comparative study
摘要:
目的 探讨18F-氟脱氧葡萄糖(18F-FDG) PET-CT与唧99mTc-亚甲基二膦酸盐(99mTc-MDP)全身骨显像对转移性骨肿瘤的诊断价值。方法 93例经病理证实为恶性肿瘤的患者同时接受18F-FDG PET-CT和99mTc-MDP全身骨显像(时间间隔在1周之内),对比分析两种显像结果,骨转移的诊断通过随访2年,由病理、X射线片、CT或MRI检查结果综合决定。结果 93例恶性肿瘤患者中,经过2年随访或病理证实骨转移44例,其中18F-FDG PET-CT灵敏度、特异度和准确率分别为95.4%、91.8%和93.5%,99mTc-MDP全身骨显像分别为90.9%、63.3%和76.3%。18F-FDG PET-CT对转移性骨肿瘤诊断的灵敏度与99mTc-MDP全身骨显像相近,但特异度(t=2.53,P<0.05)和准确率t=2.47,P<0.05)均明显高于99mTc-MDP全身骨显像。结论 PET-CT对转移性骨肿瘤有较高的诊断价值。
Abstract:
Objective To investigate the diagnostic value of 18F-fluorodcoxyglucose PET-CT and 99mTc-methylene phosphonate whole body imaging in detection bone metastases.Methods 18F-FDG PET-CT and 99mTc-MDP whole body bone scan were both performed in 93 patients with malignant tumors testified by pathology.Bone metastases were confirmed by pathology,X ray or CT or MRI and follow-up for not less than 2 years.Results Of the 93 patients 44 were confirmed to have bone metastases by 2 years follow-up or pathology.The sensitivity,specificity and accuracy of 18F-FDG PET-CT were 95.4%,91.8%,93.5%,and 99mTc-MDP bone imaging were 90.9%,63.3%,76.3%,respectively.18F-FDG PET-CT has a better specificity (t=2.53,P<0.05)and accuracy (t=2.47,P<0.05)in detecting bone metastases than that of 99mTc-MDP bone imaging.Conclusion PET-CT is a more valuable method in the diagnosis of bone metastases.

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备注/Memo

备注/Memo:
收稿日期:2007-12-27。
通讯作者:莫逸(E-mail:moyi828@sina.com)
更新日期/Last Update: 1900-01-01