[1]董爱生,田建明.PET、SPECT及MRS在帕金森病诊断中的应用[J].国际放射医学核医学杂志,2005,29(6):244-248.
　DONG Ai-sheng,TIAN Jian-ming.The application of PET、SPECT and MRS in Parkinson’s disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(6):244-248.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第6期
页码:
244-248
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The application of PET、SPECT and MRS in Parkinson’s disease
作者:
董爱生;  田建明
200433 上海, 第二军医大学长海医院放疗科
Author(s):
DONG Ai-sheng;  TIAN Jian-ming
Department of Radiology, Changhai Hospital of the Second Military Medical University, Shanghai 200433, China
关键词:
正电子发射体层显像; 单光子发射体层显像; 磁共振波谱成像; 帕金森病
Keywords:
positron emission tomography; single photon emission computed tomography; magnetic resonance spectroscopy; Parkinson’s disease
分类号:
R814.42;R817.4
摘要:
PET和SPECT可以在体研究帕金森病患者黑质纹状体多巴胺能系统退变的神经化学、血流动力学及代谢改变,脑血流和代谢的激活研究表明,帕金森病患者补偿运动区和背侧额叶前部运动区的激活功能受损。纹状体多巴胺能神经元退变可以通过PET和SPECT进行定量分析,在帕金森病患者中纹状体对18F标记的多巴摄取明显下降,壳核比尾状核下降明显,且与运动异常症状的严重程度及病程呈负相关。PET和SPECT使无创评价多巴胺受体密度的变化成为可能。同时,MRS可以揭示脑内几种含氢含磷化合物的浓度变化。应用这些互相补充的技术可获得关于帕金森病脑功能的信息。
Abstract:
PET and SPECT provide the means to studying in vivo the neurochemical, hemodynamic or metabolic consequences of the degeneration of the nigrostriatal dopaminergic system in Parkinson’s disease (PD). Activation studies using cerebral blood flow and metabolism measurements during a motor task reveal an impaired ability to activate the supplementary motor area and dorsolateral prefrontal cortex in PD. The extent of striatal dopaminergic denervation can be quantified with PET and SPECT. Striatal uptake of 18F-dopa is markedly decreased in PD, more in the putamen than in the caudate nucleus, and inversely correlates with the severity of motor signs and with duration of disease. PET and SPECT make possible the assessment by noninvasive means of the changes in dopamine receptor density. Meanwhile, MRS can reveal changes in concentra-tion of several hydrogenate and phosphoric compounds in the brain. The functional information of brain in PD can be obtained with these complementary techniques.

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备注/Memo

备注/Memo:
收稿日期:2005-01-20。
更新日期/Last Update: 1900-01-01