[1]庄明明,问奕欣,洪晓鹏,等.肝硬化患者治疗前后可溶性细胞间黏附分子-1水平变化及其临床意义[J].国际放射医学核医学杂志,2005,29(3):118-120.
　ZHUANG Ming-ming,WEN Yi-xin,HONG Xiao-peng,et al.Serum soluble intercellular adhesion molecule-l and its clinic significance in patients with liver cirrhosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(3):118-120.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第3期
页码:
118-120
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Serum soluble intercellular adhesion molecule-l and its clinic significance in patients with liver cirrhosis
作者:
庄明明;  问奕欣;  洪晓鹏;  郑卫军
515300 广东, 广东普宁华侨医院检验科
Author(s):
ZHUANG Ming-ming;  WEN Yi-xin;  HONG Xiao-peng;  ZHENG Wei-jun
Depatment of Labouratory, Puning Overseas Chinese Hospital, Guangdong Puning 528031, China
关键词:
肝硬化; 细胞间黏附分子-1; 酶联免疫吸附试验; 肝功能试验
Keywords:
liver cirrhosis; intercellular adhesion molecule-l; enzyme linked immunosorbent assay; liver function test
分类号:
Q345.2
摘要:
目的: 探讨肝硬化患者治疗前后血清可溶性细胞间黏附分子-1(sICAM-1)水平变化与肝细胞损伤的关系。方法: 用酶联免疫吸附试验检测50例肝硬化患者和20例正常对照者血清sICAM-1水平。结果: 肝硬化患者血清sICAM-1水平高于正常对照组(t=2.874,P<0.01);肝硬化患者血清sICAM-1水平与谷草转氨酶(GOT)水平呈正相关(r=0.275,P<0.05),与血清白蛋白(ALB)水平呈负相关(r=-0.4812,P<0.01);从ChildA级到ChildC级,血清sICAM-1水平逐步升高(r=0.3698,P<0.05);重组人生长激素(rhGH)治疗组和常规治疗组治疗后GOT、血尿素氮(BUN)、总胆红素(SB)、肌酐(Cr)、sICAM-1水平均低于治疗前;rhGH治疗组治疗后BUN、Cr、sICAM-1水平较常规治疗组下降明显。rhGH治疗组和常规治疗组显效率、有效率、无效率分别为45.45%、36.36%、18.18%和36.36%、45.45%、27.27%。结论: 肝硬化患者血清sICAM-1水平增高与肝细胞损伤、肝功能障碍有关,血清sICAM-1水平监测可作为临床观察肝硬化患者病变活动的重要免疫学指标。
Abstract:
Objective: To investigate the level of serum soluble intercellular adhesion molecule-l(sICAM-1) and assess its role in liver function injury of cirrhosis. Methods: The sICAM-1 was measured by enzyme linked immunosorbent assay in serum samples collected from 50 liver cirrhosis patients and 20 healthy controls. Liver function tests performed in all samples. Results: Serum levels of sICAM-1 were signifi-cantly increased in patients with liver cirrhosis compared with healthy controls(t=2.874, P<0.01). Serum levels of sICAM-1 correlated positively with glutamic oxaloacetic transaminase(GOT)(r=0.2754, P<0.05) and negative with albumin(ALB) (r=-0.4812, P<0.01). Serum levels of sICAM-1 were correlated positively(r=0.3698, P<0.05) with assessment score of disease severity(Child classification). The contents of GOT, blood urea nitrogen(BUN), superfamily bilirubin(SB), creatinine(Cr), sICAM-1 were obviously lower than that of pretreatment. The contents of BUN、Cr、sICAM-1 comparision between recombination human growth hormone(rhGH) group and routine group in the after treatment were front obviously lower than that latter. The apparent efficiency, efficiency and inefficiency were 45.45%, 36.36% and 18.18% in rhGH group. The apparent efficiency, efficiency and inefficiency were 36.36%, 45.45%, and 27.27% in routine group. Conclusion: sICAM-1 is markedly elevated in liver cirrhosis and correlated with parameters of liver func-tion. sICAM-l may be useful in assessing the immunopathology of the disease process in liver cirrhosis.

参考文献/References:

1 Wallace JD, Abbott-Johnson WJ, Crawford DH, et al. GH treatment in adults with chronic liver disease:a randomized, double-blind,placebo-controlled, cross-over study[J]. J Clin Endocrinol Metab,2002, 87(6):2751-2759.
2 向海平, 金荣华, 郭新会.重组人生长激素对肝炎肝硬化患者生长激素抵抗状况改善的研究[J].临床肝胆病杂志,2004,20(2):93-95.
3 王洪涛, 邓美海, 区庆嘉.重组生长激素对实验性肝硬化肝细胞生长激素受体表达的调控作用[J].中华普通外科杂志,2002,17(2):93-95.
4 Wang HT, Chen S, Wang J, et al. Expression of growth hormone receptor and its mRNA in hepatic cirrhosis[J]. World J Gastroenterol, 2003, 9(14):765-770.
5 王若伦, 晓光.重组生长激素与人血清白蛋白治疗肝硬化低蛋白血症的疗效比较[J].广州医学院学报,2001,29(3):10-11.

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备注/Memo

备注/Memo:
收稿日期:2004-12-07。
更新日期/Last Update: 1900-01-01