[1]王欣茹,罗庆良,王宝勤,等.中子急性放射病的特点及治疗研究进展[J].国际放射医学核医学杂志,2003,27(4):178-181.
　WANG Xin-ru,LUO Qing-liang,WANG Bao-qing,et al.The characters and developments of therapy and research of neutron-induced acute radiation sickness[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(4):178-181.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第4期
页码:
178-181
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
The characters and developments of therapy and research of neutron-induced acute radiation sickness
作者:
王欣茹1;  罗庆良1;  王宝勤1;  董书魁2
1. 100850 北京, 军事医学科学院放射医学研究所;
2. 100088 北京, 第二炮兵总医院检验科
Author(s):
WANG Xin-ru1;  LUO Qing-liang1;  WANG Bao-qing1;  DONG Shu-kui2
Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
关键词:
中子; 急性放射病; 重组人白细胞介素11; 治疗
Keywords:
neutron; acute radiation sickness; recombinant human interleukin-11; therapy
分类号:
R81.05;R818.71
摘要:
中子可对机体造成多种损伤而导致ARS(急性放射病)。中子ARS胃肠道症状重,早期死亡率高,缺乏特异性治疗方法,综合对症治疗是救治的基本手段,细胞因子可改善造血功能。分子生物学技术的快速发展和研究工作的不断深入,rhIL-11(重组人白细胞介素11)等一批促进胃肠黏膜再生的细胞因子的出现,为中子ARS的临床救治带来了新的希望。
Abstract:
Neutron radiation will exert seriously lesions on body and lead to acute radiation sickness (ARS).Neutron-induced ARS is characterized by complicated symptoms of gastrointestinal,high earlier death rate and lacking of specially therapeutic approaches.The primarily curable method is to treat patients with comprehensive means such as anti-infection,anti-bleeding and blood infusion,et.Cytokines can improve the hematopoietic functions of bone marrow.With the rapid development of the molecular biology and the emergence of cytokines such as recombinant human interleukin-11that could help the regeneration of the gastrointestinal mucosa,neutron-induced ARS will be treated with new methods.

参考文献/References:

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[10] Greenwood-Van Meerveld B, Venkova K, Keith Jc Jr. Recombinant human interleukin-11 restores smooth muscle function in the jejunum and colon of human leukocyte antigen-B27 rats with intestinal inflammation[J]. J Pharmacol Exp Ther, 2001, 299(1): 58-66.
[11] Kuenzler KA, Pearson PY, Schwartz MZ, et al. Interleukin-11 enhances intestinal absorptive function after ischemiareperfusion injury[J]. Pediatr Surg, 2002, 37(3): 457-459.

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[10]叶根耀.急性放射病临床诊治研究进展[J].国际放射医学核医学杂志,1997,21(5):199.

备注/Memo

备注/Memo:
收稿日期:2003-03-06
基金项目:全军十五指令性课题(01L019)
作者简介:王欣茹(1968-),女,实验师,硕士研究生,主要从事急性放射病治疗研究;罗庆良(1952-),男,研究员,主要从事急性放射病治疗研究;王宝勤(1941-),男,副研究员,主要从事急性放射病治疗研究;董书魁(1953-),男,主任,主要从事急性辐射损伤生物效应研究。
更新日期/Last Update: 1900-01-01