[1]邹珍,常娅妮,武志芳.常见的99Tcm-MDP骨扫描骨外摄取研究进展[J].国际放射医学核医学杂志,2017,41(2):137-142,155.[doi:10.3760/cma.j.issn.1673-4114.2017.02.011]
 Zou Zhen,Chang Yani,Wu Zhifang.Extraosseous findings on bone scintigraphy and research progress of its mechanism[J].International Journal of Radiation Medicine and Nuclear Medicine,2017,41(2):137-142,155.[doi:10.3760/cma.j.issn.1673-4114.2017.02.011]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
41
期数:
2017年第2期
页码:
137-142,155
栏目:
综述
出版日期:
2017-03-25

文章信息/Info

Title:
Extraosseous findings on bone scintigraphy and research progress of its mechanism
作者:
邹珍 常娅妮 武志芳
030001 太原, 山西医科大学第一医院核医学科
Author(s):
Zou Zhen Chang Yani Wu Zhifang
Department of Nuclear Medicine, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
关键词:
99m锝美罗酸盐全身骨扫描骨外摄取钙化
Keywords:
Technetium Tc 99m medronateWhole-body bone scintigraphyExtraosseous uptakeCalcification
DOI:
10.3760/cma.j.issn.1673-4114.2017.02.011
摘要:
99Tcm-MDP可通过离子交换或化学吸附的方式与骨组织内羟基磷灰石晶体结合,从而特异性地显示骨骼影像,在临床上主要用于骨骼系统疾病的诊断。然而临床上经常可以见到骨外软组织摄取,骨外摄取的机制目前仍不清楚,多数研究认为与软组织钙化(营养不良性钙化、转移性钙化等)、局部血流变化及伪影有关,也可能与放射性显像剂与某些成分结合形成大分子有关。了解骨外摄取的原因便可通过骨扫描为临床提示其他系统可能的病变,减少盲目检查,提高骨扫描的诊断价值。笔者就当前国内外相关文献中报道的骨扫描中的骨外摄取及其可能的原因进行综述。
Abstract:
Chemisorption or ion exchange of 99Tcm-MDP on the surface of hydroxyapatite crystals can facilitate bone imaging, which can be used for the diagnosis of various bone disorders. However, extraosseous uptake in soft tissue structures on bone scans has been observed in some instances. Although the exact mechanism of its occurrence is currently unclear, most researchers have proposed that its mechanism include calcification of soft tissues(e.g., dystrophic calcification, and metastatic calcification), increased regional vascularity, technical artifacts, and radiopharmaceutical binding to macromolecules in the tissues. Identifying the specific mechanisms and detecting the occurrence of extraosseous uptake on the bone scan can facilitate the detection of disorders in other systems, thus reducing examinations and enhancing the diagnostic value of the study. The present essay reviews all the related articles and illustrates the commonly encountered extraosseous uptake and its possible mechanisms.

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备注/Memo

备注/Memo:
收稿日期:2016-11-19。
通讯作者:武志芳,Email:wuzhifang01@163.com
更新日期/Last Update: 2017-04-24