[1]杨从波,李险峰.盆腔放射病的预防进展[J].国际放射医学核医学杂志,2017,41(1):40-44.[doi:10.3760/cma.j.issn.1673-4114.2017.01.008]
 Yang Congbo,Li Xianfeng.Progress in prevention of pelvic radiation disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2017,41(1):40-44.[doi:10.3760/cma.j.issn.1673-4114.2017.01.008]
点击复制

盆腔放射病的预防进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
41
期数:
2017年第1期
页码:
40-44
栏目:
综述
出版日期:
2017-01-25

文章信息/Info

Title:
Progress in prevention of pelvic radiation disease
作者:
杨从波 李险峰
030001 太原, 山西医科大学第一医院放疗科
Author(s):
Yang Congbo Li Xianfeng
Department of Radiotherapy, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
关键词:
盆腔肿瘤放射疗法辐射损伤预防
Keywords:
Pelvic neoplasmsRadiotherapyRadiation injuriesPrevention
DOI:
10.3760/cma.j.issn.1673-4114.2017.01.008
摘要:
盆腔恶性肿瘤是最常见的肿瘤之一,放疗是盆腔恶性肿瘤综合治疗的重要组成部分。放疗在提高肿瘤控制率的同时,也会对周围正常组织造成损伤。盆腔放射病(PRD)是盆腔恶性肿瘤放疗后出现的最主要的并发症,严重影响患者的生活质量。如果能够及早进行干预,采取一定的预防措施降低PRD的发生率,患者将会从中获益。笔者将结合国内外相关文献,就PRD的相关预防措施进行综述。
Abstract:
Pelvic cancer is among the most commonly diagnosed cancers, and radiotherapy is frequently conducted as a part of tumor comprehensive treatment. Radiotherapy can improve tumor control rate but can also damage surrounding normal tissue. Pelvic radiation disease is the most common complication that results from radiotherapy to a tumor of pelvic origin, thereby seriously affecting the quality of life of a patient. If early intervention can be achieved, the patient will benefit by reducing the incidence of the disease. This article reviews domestic and foreign literature on the prevention of pelvic radiation disease.

参考文献/References:

[1] Frazzoni L, La Marca M, Guido A, et al.Pelvic radiation disease:Updates on treatment options[J].World J Clin Oncol, 2015, 6(6):272-280.DOI:10.5306/wjco.v6.i6.272.
[2] Morris Al, Haboubi Y.Pelvic radiation therapy:Between delight and disaster[J].World J Gastrointest Surg, 2015, 7(11):279-288.DOI:10.4240/wjgs.v7.i11.279.
[3] Benderitter M, Gourmelon P, Bey E, et al.New emerging concepts in the medical management of local radiation injury[J].Health Phys, 2010, 98(6):851-857.DOI:10.1097/HP.0b013e-3181c9f79a.
[4] Armes J, Crowe M, Colbourne L, et al.Patients’ supportive care needs beyond the end of cancer treatment:a prospective, longitudinal survey[J].J Clin Oncol, 2009, 27(36):6172-6179.DOI:10.1200/JCO.2009.22.5151.
[5] Andreyev HJ, Wotherspoon A, Denham W, et al.Defining pelvic-radiation disease for the survivorship era[J].Lancet Oncol, 2010, 11(4):310-312.DOI:10.1016/S1470-2045(10)70026-7.
[6] Denham W, Hauer-Jensen M.Radiation induced bowel injury:a neglected problem[J].Lancet, 2013, 382(9910):2046-2047.DOI:10.1016/S0140-6736(13)61946-7.
[7] Fuccio L, Frazzoni L, Guido A.Prevention of pelvic radiation disease[J].World J Gastrointest Pharmacol Ther, 2015, 6(1):1-9.DOI:10.4292/wjgpt.v6.i1.1.
[8] Brenn T, Fletcher D.Postradiation vascular proliferations:an increasing problem[J].Histopathology, 2006, 48(1):106-114.DOI:10.1111/j.1365-2559.2005.02293.x.
[9] Andreyev J.Pelvic radiation disease[J].Colorectal Dis, 2015, 17(1):2-6.DOI:10.1111/codi.12812.
[10] Hauer-Jensen M, Denham W, Andreyev J.Radiation enteropathy——pathogenesis, treatment and prevention[J].Nat Rev Gastroenterol Hepatol, 2014, 11(8):470-479.DOI:10.1038/nrgastro.2014.46.
[11] 李幼生.从放射性盆腔病概念的产生看疾病整体治疗的重要性[J].医学研究生学报, 2016, 29(5):449-452.DOI:10.16571/j.cnki.1008-8199.2016.05.001.Li YS.Radaition pelvicopathy:a comprehensive and interdiscipli-nary approach[J].J Med Postgraduates, 2016, 29(5):449-452.
[12] Teo T, Sebag-Montefiore D, Donnellan F.Prevention and management of radiation-induced late gastrointestinal toxicity[J].Clin Oncol(R Coll Radiol), 2015, 27(11):656-667.DOI:10.1016/j.clon.2015.06.010.
[13] Laterza L, Cecinato P, Guido A, et al.Management of radiation-induced rectal bleeding[J].Curr Gastroenterol Rep, 2013, 15(11):355.DOI:10.1007/s11894-013-0355-z.
[14] 沈亚丽, 李霞, 赵娅琴, 等.宫颈癌术后放射治疗容积旋转调强与静态调强、三维适形计划的剂量学研究[J].华西医学, 2015, 30(6):1096-1100.Shen YL, Li X, Zhao YQ, et al.Dosimetric comparison among volumetric-modulated arc therapy, intensity modulated radiotherapy and three-dimensional conformal radiotherapy as adjuvant radiotherapy for cervical cancer[J].West Chin Med J, 2015, 30(6):1096-1100.
[15] Shadad K, Sullivan J, Martin D, et al.Gastrointestinal radiation injury:prevention and treatment[J].World J Gastroenterol, 2013, 19(2):199-208.DOI:10.3748/wjg.v19.i2.199.
[16] 戴丹丹, 刘孟娟, 叶晓春.氨磷汀的临床应用概况[J].海峡药学, 2014, 26(5):79-80.Dai DD, Liu MJ, Ye XC.The clinical application of amifostine[J].Strait Pharm J, 2014, 26(5):79-80.
[17] Katsanos KH, Briasoulis E, Tsekeris P, et al.Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis[J].J Exp Clin Cancer Res, 2010, 29:68.DOI:10.1186/1756-9966-29-68.
[18] Koukourakis MI, Kyrgias G, Panteliadou M, et al.Dose escalation of amifostine for radioprotection during pelvic accelerated radiotherapy[J].Am J Clin Oncol, 2013, 36(4):338-343.DOI:10.1097/COC.0b013e318248d882.
[19] KiliçD, Egehan I, Ozenirler S, et al.Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of sulphasalazine in preventing acute gastrointestinal complications due to radiotherapy[J].Radiother Oncol, 2000, 57(2):125-129.DOI:10.1016/S0167-8140(00)00254-1.
[20] Pal S, Adhikary SS, Bhattacharya B, et al.A prospective randomized controlled trial to study the role of sulfasalazine in prevention of acute gastrointestinal toxicity associated with concurrent chemoradiation in carcinoma cervix[J].Clin Cancer Investig J, 2013, 2:118-121.DOI:10.4103/2278-0513.113633.
[21] Gibson RJ, Keefe DM, Lalla RV, et al.Systematic review of agents for the management of gastrointestinal mucositis in cancer patients[J].Support Care Cancer, 2013, 21(1):313-326.DOI:10.1007/s00520-012-1644-z.
[22] Jahraus CD, Bettenhausen D, Malik U, et al.Prevention of acute radiation-induced proctosigmoiditis by balsalazide:a randomized, double-blind, placebo controlled trial in prostate cancer patients[J].Int J Radiat Oncol Biol Phys, 2005, 63(5):1483-1487.DOI:10.1016/j.ijrobp.2005.04.032.
[23] 王锦, 高青.二丙酸倍氯米松和传统糖皮质激素灌肠治疗溃疡性结肠炎:Meta分析[J].胃肠病学和肝病学杂志, 2014, 23(7):774-778.DOI:10.3969/j.issn.1006-5709.2014.07.015.Wang J, Gao Q.Beclomethasone dipropionate versus traditional glucocorticosteroids enema in the treatment of ulcerative colitis:a Meta-analysis[J].Chin J Gastroenterol Hepatol, 2014, 23(7):774-778.
[24] Fuccio L, Guido A, Laterza L, et al.Randomised clinical trial:preventive treatment with topical rectal beclomethasone dipropionate reduces post-radiation risk of bleeding in patients irradiated for prostate cancer[J].Aliment Pharmacol Ther, 2011, 34(6):628-637.DOI:10.1111/j.1365-2036.2011.04780.x.
[25] Khan AM, Birk JW, Anderson JC, et al.A prospective randomized placebo-controlled double-blinded pilot study of misoprostol rectal suppositories in the prevention of acute and chronic radiation proctitis symptoms in prostate cancer patients[J].Am J Gastroenterol, 2000, 95(8):1961-1966.DOI:10.1111/j.1572-0241.2000.02260.x.
[26] Hille A, Schmidberger H, Hermann RM, et al.A phase III randomized, placebo-controlled, double-blind study of misoprostol rectal suppositories to prevent acute radiation proctitis in patients with prostate cancer[J].Int J Radiat Oncol Biol Phys, 2005, 63(5):1488-1493.DOI:10.1016/j.ijrobp.2005.05.063.
[27] O’brien PC, Franklin CI, Dear KB, et al.A phase III double-blind randomised study of rectal sucralfate suspension in the prevention of acute radiation proctitis[J].Radiother Oncol, 1997, 45(2):117-123.DOI:10.1016/S0167-8140(97)00146-1.
[28] Hovdenak N, Sørbye H, Dahl O.Sucralfate does not ameliorate acute radiation proctitis:randomised study and meta-analysis[J].Clin Oncol(R Coll Radiol), 2005, 17(6):485-491.DOI:10.1016/j.clon.2005.04.011.
[29] Kneebone A, Mameghan H, Bolin T, et al.Effect of oral sucralfate on late rectal injury associated with radiotherapy for prostate cancer:A double-blind, randomized trial[J].Int J Radiat Oncol Biol Phys, 2004, 60(4):1088-1097.DOI:10.1016/j.ijrobp.2004.04.033.
[30] Reiff C, Kelly D.Inflammatory bowel disease, gut bacteria and probiotic therapy[J].Int J Med Microbiol, 2010, 300(1):25-33.DOI:10.1016/j.ijmm.2009.08.004.
[31] Fuccio L, Guido A, Eusebi LH, et al.Effects of probiotics for the prevention and treatment of radiation-induced diarrhea[J].J Clin Gastroenterol, 2009, 43(6):506-513.DOI:10.1097/MCG.0b013e3181a1f59c.
[32] Fuccio L, Guido A, Andreyev HJ.Management of intestinal complications in patients with pelvic radiation disease[J/OL].Clin Gastroenterol Hepatol, 2012, 10(12):1326-1334.e4[2016-10-20].https://www.ncbi.nlm.nih.gov/pubmed/22858731.DOI:10.1016/j.cgh.2012.07.017.

相似文献/References:

[1]李景涛,邓垒,张文珏,等.广泛期小细胞肺癌胸部IMRT后发生放射性肺炎的危险因素分析[J].国际放射医学核医学杂志,2016,40(2):100.[doi:10.3760/cma.j.issn.1673-4114.2016.02.003]
 Li Jingtao,Deng Lei,Zhang Wenjue,et al.Risk factor analysis for predicting radiation pneumonitis in extensive stage small cell lung cancer patients receiving IMRT thoracic radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):100.[doi:10.3760/cma.j.issn.1673-4114.2016.02.003]
[2]刘佳,高刚,朴春南,等.调节肿瘤放射敏感性的miRNAs研究进展[J].国际放射医学核医学杂志,2016,40(2):159.[doi:10.3760/cma.j.issn.1673-4114.2016.02.015]
 Liu Jia,Gao Gang,Piao Chunnan,et al.Progress of microRNAs in regulating tumor radiation sensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):159.[doi:10.3760/cma.j.issn.1673-4114.2016.02.015]
[3]陈晓艳,张江虹,邵春林.STAT3与辐射敏感相关性的研究进展[J].国际放射医学核医学杂志,2016,40(3):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
 Chen Xiaoyan,Jianghong,Shao Chunlin.Research progresses of correlation between STAT3 and radiosensitivity[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):191.[doi:10.3760/cma.j.issn.1673-4114.2016.03.007]
[4]赵德云,李百龙.植物提取物防治放射性肺损伤的现状与展望[J].国际放射医学核医学杂志,2016,40(3):208.[doi:10.3760/cma.j.issn.1673-4114.2016.03.010]
 Zhao Deyun,Li Bailong.Protective and therapeutic effects of plant extracts on radiation-induced lung injury:present status and future prospects[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):208.[doi:10.3760/cma.j.issn.1673-4114.2016.03.010]
[5]田琦,蒋宁一,郑丽.265例精细个体化131I治疗Graves甲亢的疗效观察[J].国际放射医学核医学杂志,2016,40(4):259.[doi:10.3760/cma.j.issn.1673-4114.2016.04.004]
 Tian Qi,Jiang Ningyi,Zheng Li.Therapeutic effect of fine individual 131I treatment on Graves disease hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):259.[doi:10.3760/cma.j.issn.1673-4114.2016.04.004]
[6]邓大平,卢峰,孙洪强,等.颅脑肿瘤放射治疗时射野外器官吸收剂量体模法测量与分析[J].国际放射医学核医学杂志,2016,40(4):272.[doi:10.3760/cma.j.issn.1673-4114.2016.04.007]
 Deng Daping,Lu Feng,Sun Hongqiang,et al.Test and analysis of out-of-field organ dose in intracranial tumor radiotherapy using phantom[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):272.[doi:10.3760/cma.j.issn.1673-4114.2016.04.007]
[7]赵舒怡,储小飞,樊赛军.血清肿瘤标志物与肿瘤放疗疗效评估的研究进展[J].国际放射医学核医学杂志,2015,39(5):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
 zhao shuyi,chu xiaofei,fan saijun..progression of study on serum tumor markers in evaluation of tumor radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):427.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 018]
[8]赵徵鑫,翟贺争,张文艺,等.质子重离子治疗肿瘤的进展[J].国际放射医学核医学杂志,2016,40(5):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
 Zhao Zhixin,Zhai Hezheng,Zhang Wenyi,et al.Development of proton heavy ion in tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):384.[doi:10.3760/cma.j.issn.1673-4114.2016.05.010]
[9]段永璇,邹晓艳,段秀梅,等.数据解析在肿瘤放射治疗中的应用[J].国际放射医学核医学杂志,2015,39(6):505.[doi:10.3760/cma.j.issn.1673-4114.2015.06.015]
 Duan Yongxuan,Zou Xiaoyan,Duan Xiumei,et al.Data analysis in the field of tumor radiation therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):505.[doi:10.3760/cma.j.issn.1673-4114.2015.06.015]
[10]贾立立,孟粹达,刘晓冬,等.头颈部肿瘤放疗中转化医学相关机制的研究进展[J].国际放射医学核医学杂志,2015,39(3):247.[doi:10.3760/cma.j.issn.1673-4114.2015.03.013]
 Jia Lili,Meng Cuida,Liu Xiaodong,et al.Development in translational medicine-related mechanisms of radiotherapy for head and neck cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):247.[doi:10.3760/cma.j.issn.1673-4114.2015.03.013]

备注/Memo

备注/Memo:
收稿日期:2016-10-29。
通讯作者:李险峰,Email:lixianfeng-lxf@263.net
更新日期/Last Update: 1900-01-01