[1]张胤,陈跃.18F-氟化钠PET/CT诊断肿瘤骨转移应用进展[J].国际放射医学核医学杂志,2015,39(1):96-102.[doi:10.3760/cma.j.issn.1673-4114.2015.01.020]
 Zhang Yin,Chen Yue.Application progress of 18F-NaF PET/CT in the diagnosis of neoplasm metastases[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):96-102.[doi:10.3760/cma.j.issn.1673-4114.2015.01.020]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第1期
页码:
96-102
栏目:
出版日期:
2015-01-25

文章信息/Info

Title:
Application progress of 18F-NaF PET/CT in the diagnosis of neoplasm metastases
作者:
张胤 陈跃
四川泸州医学院附属医院核医学科, 四川, 646000
Author(s):
Zhang Yin Chen Yue
Department of Nuclear Meaicine, Affiliated Hospital, Luzhou Medical College, Luzhou 646000, China
关键词:
氟化钠肿瘤转移正电子发射断层显像术体层摄影术X线计算机氟放射性同位素
Keywords:
SodiumBoneNeoplasm metastasesPositron-emission tomographyTomographyX-rayFluorine radioisotopes
DOI:
10.3760/cma.j.issn.1673-4114.2015.01.020
摘要:
18F-氟化钠(18F-NaF)作为骨扫描示踪剂已有50多年的历史,期间由于正电子探测器的缺乏等因素被99Tcm-MDP替代。随着PET/CT的发展,将18F-NaF作为PET/CT示踪剂的研究逐渐增多。18F-NaF本身的药物特性以及PET/CT相对于SPECT/CT的优势,使得18F-NaF PET/CT诊断恶性肿瘤骨转移的灵敏度、特异度优于99Tcm-MDP骨扫描。与99Tcm-MDP骨显像、18F-FDG PET/CT和MRI相比,18F-NaF PET/CT在诊断恶性肿瘤骨转移时具有更高的灵敏度,并且对于不同肿瘤的骨转移有不同的诊断价值。18F-NaF联合18F-FDG PET/CT扫描被证明具有一定的应用价值。18F-NaF PET/CT是诊断恶性肿瘤骨转移的安全、有效、简便、无创的方法。
Abstract:
18F-NaF has been used for the tracer of bone scans more than 50 years. After a period of decline for the shortage of positron detector, scholars using 18F-NaF as radioactive tracer is increasing with the development of PET/CT. The natural medicinal property of 18F-NaF and the advantage of PET make the 18F-NaF PET/CT a better way to assess malignant osseous metastases than 99Tcm-MDP bone scan in sensitivity and specificity. When compared with 99Tcm-MDP bone scan, 18F-FDg PET/CT and magnetic resonance imaging, 18F-NaF PET/CT has higher sensitivity in detecting osseous metastases of malignancies. 18F-NaF PET/CT also has different diagnostic values in management of patients with malignancies. Combine18F-NaF and 18F-FDg in one PET/CT examination is proven to have potential in clinical management. 18F-NaF PET/CT is a safe, effective, simple and noninvasive method in diagnosis of bone metastases in malignant tumor.

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备注/Memo

备注/Memo:
收稿日期:2014-12-01。
通讯作者:陈跃,Email:chenvue5523@126.com
更新日期/Last Update: 1900-01-01