[1]白佳利,于程程,王德芝,等.对甲基桂皮丹酚酯抗辐射活性的研究[J].国际放射医学核医学杂志,2013,37(3):139-142.[doi:10.3760/cma.j.issn.1673-4114.2013.03.003]
　BAI Jia-li,YU Cheng-cheng,WANG De-zhi,et al.Protective effect of P-methyl cinnamic paeonol esters against radiation damage[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(3):139-142.[doi:10.3760/cma.j.issn.1673-4114.2013.03.003]
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对甲基桂皮丹酚酯抗辐射活性的研究(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第3期
页码:
139-142
栏目:
论著
出版日期:
2013-05-25

文章信息/Info

Title:
Protective effect of P-methyl cinnamic paeonol esters against radiation damage
作者:
白佳利;  于程程;  王德芝;  沈秀;  郝建秀;  王浩;  龙伟;  周则卫
300192 天津, 北京协和医学院中国医学科学院放射医学研究所, 天津市分子核医学重点实验室
Author(s):
BAI Jia-li;  YU Cheng-cheng;  WANG De-zhi;  SHEN Xiu;  HAO Jian-xiu;  WANG Hao;  LONG Wei;  ZHOU Ze-wei
Tianjin Key Laboratory of Molecular Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China
关键词:
辐射耐受性; 铯放射性同位素; 对甲基桂皮丹酚酯
Keywords:
Radiation tolerance; Cesium radioisotopes; P-methyl cinnamic paeonol esters
DOI:
10.3760/cma.j.issn.1673-4114.2013.03.003
摘要:
目的 研究对甲基桂皮丹酚酯的抗辐射活性。方法 以6~8周龄的ICR小鼠作为研究对象,经137Cs γ射线一次性全身照射后,以30 d存活率、血液生化指标、脏器指数及肺和肝的超氧化物歧化酶(SOD)、丙二醛为指标,考察低、中、高3个剂量组的对甲基桂皮丹酚酯的抗辐射损伤效应。结果 对甲基桂皮丹酚酯可以提高经8.5 Gy 137Cs γ射线一次性全身照射损伤ICR小鼠的30 d存活率,对小鼠经6.5 Gy 137Cs γ射线一次性全身照射损伤生理指标影响的检测结果显示,对甲基桂皮丹酚酯在不同程度上提高了血小板和DNA含量、胸腺指数和脾脏指数;且SOD水平随着对甲基桂皮丹酚酯剂量的增加而增加,而丙二醛水平则有所降低,尤其是高剂量组的效果较显著。结论 对甲基桂皮丹酚酯可能具有抗辐射损伤作用。
Abstract:
Objective To study the radiaition protective effect of P-methyl cinnamic paeonol esters on irradiated mice.Methods ICR mice of age 6-8 weeks were selected as investigated subjects,then the mice whole body were irradiated with 6.5 Gy or 8.5 Gy137Cs γ-ray.The 30-day survival rates,organ indexes,superoxide dismutase (SOD)and malondialdehyde levels in lung and liver were observed to evaluate the radiation protective effect of P-methyl cinnamic paeonol esters in high,medium,low dose groups.Results P-methyl cinnamic paeonol esters increased the 30-day survival rates of 8.5 Gy whole body irradiated mice.And after 6.5 Gy whole body irradiation,P-methyl cinnamic paeonol esters could enhance the platelet counts,DNA levels and thymus,spleen index.Meanwhile,SOD levels were increased with the increasing dose of P-methyl cinnamic paeonol esters,while malondialdehyde levels were decreased,especially in the high dose group.Conclusion Pmethyl cinnamic paeonol esters may play an important role in radiation resistance.

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备注/Memo

备注/Memo:
收稿日期:2012-09-28。
基金项目:国家自然科学基金(81202153);北京协和医学院青年基金(2012D03);中国医学科学院放射医学研究所学科发展基金(SF1227);教育部博士点新教师基金(20121106120042)
通讯作者:周则卫,Email:zhouzewei666@yahoo.com.cn
更新日期/Last Update: 1900-01-01