[1]钟兴祥,郑吉祥,蓝冠章,等.Graves甲亢131I治疗前后血清TRAb动态变化及临床价值[J].国际放射医学核医学杂志,2011,35(2):110-113.[doi:10.3760/cma.j.issn.1673-4114.2011.02.011]
　ZHONG Xing-xiang,ZHENG Ji-xiang,LAN Guan-zhang,et al.Changes of serum TRAb after 131I radiotherapy in patients of Graves hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(2):110-113.[doi:10.3760/cma.j.issn.1673-4114.2011.02.011]
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Graves甲亢131I治疗前后血清TRAb动态变化及临床价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第2期
页码:
110-113
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Changes of serum TRAb after 131I radiotherapy in patients of Graves hyperthyroidism
作者:
钟兴祥;  郑吉祥;  蓝冠章;  楼云龙
514031 广东梅州, 广东省梅州市人民医院核医学科
Author(s):
ZHONG Xing-xiang;  ZHENG Ji-xiang;  LAN Guan-zhang;  LOU Yun-long
Department of Nuclear Medicine, The People’s Hospital of Meizhou, Guang dong Meizhou 514031, China
关键词:
格雷夫斯病; 碘放射性同位素; 受体; 促甲状腺素; 抗体; 动态变化
Keywords:
Graves disease; Iodine radioisotopes; Receptors; thyrotropin; Antibodies; Devlopmental changes
DOI:
10.3760/cma.j.issn.1673-4114.2011.02.011
摘要:
目的 通过测定Graves甲亢患者131I治疗前后血清促甲状腺激素受体抗体(TRAb)水平的动态变化,探讨TRAb在131I治疗Graves甲亢中的临床价值。方法 回顾性分析我院2008年至2010年12月收治的经131I治疗的Graves甲亢患者,其中有3~18个月完整随访资料者128例,与45名健康对照者分别于131I治疗前及治疗3、6、12和18个月后采用放射受体分析法动态测定其血清TRAb水平的变化,并进行统计学分析。结果 45名健康对照者血清TRAb水平为(2.95±1.48)U/L,128例Graves甲亢患者在131I治疗前血清TRAb水平为(81.52±36.15)U/L,高于健康对照者(t=8.17,P<0.01);131I治疗3个月后患者血清TRAb水平[(127.13±49.05)U/L)]明显高于治疗前(t=4.92,P<0.01);治疗6个月后患者血清TRAb水平[(59.82±28.51)U/L)]开始降低,与健康对照者比较差异有统计学意义(t=6.89,P<0.01);治疗12个月后患者血清TRAb水平[(12.53±9.26)U/L)]明显降低,与健康对照者比较差异有统计学意义(t=2.29,P<0.01);治疗18个月后患者血清TRAb水平[(4.29±2.56)U/L)]与健康对照者比较差异无统计学意义(t=1.53,P>0.05)。结论 动态观察Graves甲亢患者131I治疗前后TRAb水平的变化具有指导治疗、判断疗效、预测复发、鉴别甲状腺功能减退症等重要的临床价值。
Abstract:
Objective To study the changes of serum thyrotrophin receptor antibody (TRAb) in patients of Graves’ hyperthyroidism after 131I radiotherapy and explore its clinical significances. Methods A total of 128 patients and 45 nomal controls were included in the study. Serum concentration of TRAb was measured by radioreceptor assay before and at 3, 6, 12 and 18 months after 131I radiotherapy. Results The TRAb level of 45 nomal controls was (2.95+1.48) U/L. Abnormally higher TRAb level [(81.52+36. 1 5) U/L)]was noted in patients before 131J treatment(t=8.17, P<0.01). The TRAb titer increased further to(127.13±49.05)U/L at 3 months after therapy(t=4.92,P<0.01),before it dropped to (59.82±28.51)U/L and (12.53±9.26)U/L at 6 and 12 months respectively (t=6.89 and t=2.29,P<0.01). At 18 months after 131I radiotherapy, the level of TRAb [(4.29+2.56)U/L)]was back to normal with no difference to that of controls(t=1.53,P>0.05).Conclusion It is of great significance to measure serum concentrations of TRAb after 131I radiotherapy,which is of important clinical value for therapy guidance, efficacy assessment, recurrence prediction and hypothyroidism identification.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2011-01-21。
通讯作者:钟兴祥,Email:zhxx.htyy@163.com
更新日期/Last Update: 1900-01-01