[1]刘道佳,唐明灯,林端瑜,等.99Tcm-MDP全身骨显像、99Tcm-MDP SPECT-CT和18F-FDG SPECT-CT探测脊柱转移瘤的比较[J].国际放射医学核医学杂志,2011,35(2):89-92.[doi:10.3760/cma.j.issn.1673-4114.2011.02.006]
　LIU Dao-jia,TANG Ming-deng,LIN Duan-yu,et al.Comparision of the value of 99Tcm-MDP bone scintigraphy, 99Tcm-MDP SPECT-CT and 18F-FDG SPECT-CT in detecting bone metastases of spine[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(2):89-92.[doi:10.3760/cma.j.issn.1673-4114.2011.02.006]
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99Tcm-MDP全身骨显像、99Tcm-MDP SPECT-CT和18F-FDG SPECT-CT探测脊柱转移瘤的比较(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
35
期数:
2011年第2期
页码:
89-92
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Comparision of the value of 99Tcm-MDP bone scintigraphy, 99Tcm-MDP SPECT-CT and 18F-FDG SPECT-CT in detecting bone metastases of spine
作者:
刘道佳;  唐明灯;  林端瑜;  倪雷春;  林小敏
350014 福州, 福建省肿瘤医院核医学科
Author(s):
LIU Dao-jia;  TANG Ming-deng;  LIN Duan-yu;  NI Lei-chun;  LIN Xiao-min
Department of Nuclear Medicine, Fujian Tumor Hospital, Fuzhou 350014, China
关键词:
脊柱; 肿瘤转移; 体层摄影术; 发射型计算机; 单光子; 体层摄影术; X线计算机; 氟脱氧葡萄糖F18; 99m锝美罗酸盐
Keywords:
Spine; Neoplasm metastasis; Tomography; emission-computed; single-photon; Tomography; X-ray computed; Fluorodeoxyglucose F18; Technetium Tc 99m medronate
DOI:
10.3760/cma.j.issn.1673-4114.2011.02.006
摘要:
目的 比较99Tcm-亚甲基二膦酸盐(99Tcm-MDP)全身骨显像、99Tcm-MDPSPECT-CT与18F-FDG SPECT-CT诊断脊柱转移瘤的临床价值。方法 对行常规99Tcm-MDP全身骨显像的88例肿瘤患者同时行99Tcm-MDP SPECT-CT,同期(2周内)行18F-FDG SPECT-CT。回顾性分析患者临床资料,以病理结果或两种以上影像技术(MRI、CT等)结果或随访2年以上结果为最终结果,比较99Tcm-MDP全身骨显像、99Tcm-MDP SPECT-CT与18F-FDG SPECT-CT的诊断结果。结果 经临床随访或病理证实,88例肿瘤患者诊断脊柱转移瘤48例、良性病变19例、未转移2l例。99Tcm-MDP全身骨显像诊断脊柱转移瘤的灵敏度、特异度、阳性预测值、阴性预测值及准确率分别为89.6%(43/48)、62.5%(25/40)、74.1%(43/58)、83.3%(25/30)及63.4%(68/88),99Tcm-MDP SPECT-CT分别为93.8%(45/48)、92.5%(35/40)、90.0%(45/50)、92.1%(35/38)及81.6%(80/88);18F-FDG SPECT-CT分别为97.9%(47/48)、97.5%(39/40)、97.9%(48/49)、97.5%(39/40)及87.8%(86/88)。SPECT-CT解决了99Tcm-MDP全身骨显像对阳性病灶精确解剖定位难的问题,明显提高了对骨良性病灶的诊断能力,降低了诊断脊柱转移瘤的假阳性率。18F-FDG SPECT-CT较99Tcm-MDP全身骨显像更具肿瘤特异性,对骨骼良恶性病灶的鉴别具有更强的能力,提高了脊柱转移瘤诊断的特异度(χ2=15.313,P<0.001)和准确率(χ2=16.831,P<0.001)。结论 99Tcm-MDP SPECT-CT和18F-FDG SPECT-CT对脊柱转移瘤的诊断效能高于99Tcm-MDP全身骨显像,具有较高的临床价值。
Abstract:
Objective To co mpare the value of 99Tcm-methylene diphosphonate (99Tcm-MDP)bone scintigraphy, 99Tcm-MDP SPECT-CT and 18F-FDG in detecting bone metastases of spine. Methods Retro-spective analysis of 88 tumor patients who underwent 99Tcm-MDP planar bone scintigraphy, then performed 99Tcm-MDP SPECT-CT immediately, and then underwent 18F-FDG SPECT-CT within 2 weeks apart. The diagnostic results were confirmed by biopsy, MRI/CT and clinical follow-up. Results Fouty-eight of 88 patients were comfirmed to be spine bone metastases, 19 to be spine benigns, 21 to be non-metastases. The sensitivity, specificity, positivity predicitive value, negative predictive value, and accuracy of 99Tcm-MDP bone scintigraphy were 89.6%(43/48), 62.5%(25/40), 74.1% (43/58), 83.3% (25/30)and 63.4%(68/88). Those of 99Tcm-MDP SPECTCT were 93.8% (45/48), 92.5%(35/40), 90.0% (45/50), 92.1% (35/38)and 81.6%(80/88). Those of 18F-FDG SPECT-CT were 97.9% (47/48), 97.5% (39/40), 97.9% (48/49), 97.5% (39/40)and 87.8% (86/88). SPECT-CT is resolving the problem in conventional bone scintigraphy on anatomical localization of the positive lesions on bone, and reducing the false positive rate. 18F-FDG SPECT-CT is more specific than 99Tcm-MDP bone scintigraphy to the bone metastases of spine, and increasing the ability to identify bone lesion malignant or benign, and increasing the specificity(χ2=15.313, P<0.001) and accuracy(χ2=16.831, P<0.001). Conclusion The diagnostic accuracy of 99Tcm-MDP SPECT-CTand 18F-FDG SPECT-CTin detecting bone metastases of spine are both better than 99Tcm-MDP BS.They are valuable for detecting bone metastases of spine.

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备注/Memo

备注/Memo:
收稿日期:2011-08-23。
通讯作者:唐明灯,Email:tmd0603@126.com
更新日期/Last Update: 1900-01-01