[1]牟联超,李先映,石彩虹.131I治疗青少年Graves病58例临床分析[J].国际放射医学核医学杂志,2010,34(5):299-301.[doi:10.3760/cma.j.issn.1673-4114.2010.05.013]
　MU Lian-chao,LI Xian-ying,SHI Cai-hong.Analyze of 131I therapy on 58 youngsters with Graves’ disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(5):299-301.[doi:10.3760/cma.j.issn.1673-4114.2010.05.013]
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131I治疗青少年Graves病58例临床分析(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第5期
页码:
299-301
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Analyze of 131I therapy on 58 youngsters with Graves’ disease
作者:
牟联超1;  李先映1;  石彩虹2
1. 431700, 湖北省天门市第三人民医院核医学科;
2. 431700, 湖北省天门市第三人民医院超声科
Author(s):
MU Lian-chao1;  LI Xian-ying1;  SHI Cai-hong2
Department of Nuclear Medicine, The Third People’s Hospital ofTianmen, Hubei Tianmen 431700, China
关键词:
格雷夫斯病; 碘放射性同位素; 近距离放射疗法; 青少年
Keywords:
Graves disease; Iodine radioisotopes; Brachytherapy; Adolescent
DOI:
10.3760/cma.j.issn.1673-4114.2010.05.013
摘要:
目的 研究131I治疗青少年Graves病的可行性和安全性。方法 回顾性分析58例经131I治疗的青少年Graves病患者,分别于131I(剂量:148~240.5MBq)治疗前和治疗6个月后,用化学发光免疫法检测血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平及用彩色多普勒超声测量甲状腺大小;随访2~7年,评价疗效。结果 治疗6个月后,血清FT3和FT4水平明显降低(t=12.43,t=21.21,P均<0.01),TSH水平明显升高(t=10.34,P<0.01),甲状腺体积明显缩小。58例患者中,治愈31例(53.45%),好转16例(27.59%),无效7例(12.07%),甲减3例(5.17%),复发1例(1.72%)。结论 131I治疗青少年Graves病安全有效。
Abstract:
Objective To study the feasibility and curative effect of 131I therapy for youngsters with Graves’ disease. Methods Retrospective analyzed 58 youngsters with Graves’ disease, to compare the serum free triiodthyroine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone(TSH) levels with chemiluminescent immunoassay and to measure the thyroid gland size with color Doppler diagnostic apparatus before and after six months of 131I (148-240.5 MBq) therapy, then followed up for 2-7 years, and clinical efficacy was evaluated according to the results. Results After 6 months of therapy, the levels of FT3 and FT4 were significantly decreased(t=12.43, t=21.21, P<0.01), the level of TSH was significantly increased (t=10.34, P<0.01), and thyroid volume was decreased obviously. Of the 58 patients, 31 (53.45%)patients were cured, 16 (27.59%) were much better than before, and 7 (12.1%) were invalid, 3 (5.17%) were temporary hypothyroid, 1 (1.72%) recrudesced. Conclusion 131I is an effective therapy which is safe and economical to youngsters with Graves’ disease.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2010-06-01。
通讯作者:牟联超,E-mail:hbtmmlc@163.com
更新日期/Last Update: 1900-01-01