[1]郭睿,李彪.早期生长反应基因1启动子介导肿瘤基因-放疗的研究进展[J].国际放射医学核医学杂志,2010,34(4):206-208,219.[doi:10.3760/cma.j.issn.1673-4114.2010.04.004]
 GUO Rui,LI Biao.The progress of tumor gene-radiotherapy induced by Egr-1 promoter[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(4):206-208,219.[doi:10.3760/cma.j.issn.1673-4114.2010.04.004]
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早期生长反应基因1启动子介导肿瘤基因-放疗的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第4期
页码:
206-208,219
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The progress of tumor gene-radiotherapy induced by Egr-1 promoter
作者:
郭睿 李彪
200025, 上海交通大学医学院附属瑞金医院核医学科
Author(s):
GUO Rui LI Biao
Department of Nuclear Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai 200025, China
关键词:
基因表达调控放射疗法肿瘤早期生长反应基因1启动区(遗传学)
Keywords:
Gene expression regulationRadiotherapyNaoplasmsEarly growth response gene-1Promoter regions(genetics)
DOI:
10.3760/cma.j.issn.1673-4114.2010.04.004
摘要:
早期生长反应基因1(Egr-1)启动子为Egr-1上游的顺式作用元件,其活性受电离辐射、自由基等诱导剂的调控。Egr-1与治疗基因结合(如肿瘤坏死因子α基因、自杀基因等)构成基因-放射治疗体系,利用辐射在肿瘤局部从时间、空间调控治疗基因的表达,使表达产物局限于肿瘤局部发挥肿瘤杀伤效应,并降低了不良反应。放射治疗与基因治疗的结合为肿瘤治疗提供了新方法。
Abstract:
The promoter of early growth response gene-1 (Egr-1) is a cis-acting element of Egr-1, and its activity is regulated by inducers such as ionizing radiation, free radical. In designated gene-radiotherapy system, radiation combined with therapeutic gene (such as tumor necrosis factor-α gene, suicide gene) can spatially and temporally regulate therapeutic gene expression in the irradiated field, produced a marked effect,while little systemic toxicities were observed. The combination of radiotherapy and gene therapy is promising in tumor therapy.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2010-02-22。
基金项目:国家自然科学基金(81071181);上海市科委生物医药重点科技攻关项目(09431900900);上海市教委重点学科建设基金(S30203)
通讯作者:李彪,E-mail:1610363@rjh.com.cn
更新日期/Last Update: 1900-01-01