[1]何建华,喻文才,张顺琼,等.131I不同剂量法治疗甲亢疗效对比[J].国际放射医学核医学杂志,2009,33(6):351-353.[doi:10.3760/cma.j.issn.1673-4114.2009.06.010]
　HE Jian-hua,YU Wen-cai,ZHANG Shun-qiong,et al.A randomized study of different radioiodine doses treatment hyperthyroidism[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(6):351-353.[doi:10.3760/cma.j.issn.1673-4114.2009.06.010]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第6期
页码:
351-353
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
A randomized study of different radioiodine doses treatment hyperthyroidism
作者:
何建华;  喻文才;  张顺琼;  曾钦文
重庆医科大学附属永川医院核医学科, 重庆 402160
Author(s):
HE Jian-hua;  YU Wen-cai;  ZHANG Shun-qiong;  ZENG Qin-wen
Department of Nuclear Medicine, Yong churn Hospital of Chongqing Universityf Chongqing 402160, China
关键词:
甲状腺功能亢进症; 碘放射性同位素; 近距离放射疗法
Keywords:
Hyperthyroidism; Radioiodine; Brachytherapy
DOI:
10.3760/cma.j.issn.1673-4114.2009.06.010
摘要:
目的 比较131I固定剂量法和计算剂量法治疗甲亢的近期疗效。方法 148例甲亢患者随机分配为固定剂量组和计算剂量组,131I治疗后6个月随访,检测患者血清促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)和游离甲状腺素(FT4)水平,评价131I治疗效果。结果 131I治疗后6个月固定剂量组、计算剂量组甲减发生率分别为31.1%、28.4%,统计学差异无意义(χ2=0.742,P=0.528),总治愈率分别为93.3%、85.2%,统计学差异无意义(χ2=0.958,P=0.403)。不同治疗结果(甲亢、甲状腺功能正常和甲减)之间甲状腺质量的统计学差异有意义(F=13.639,P=0.000),患者年龄、24h甲状腺吸碘率(RAIU)统计学差异无意义(F=1.374,P=0.241;F=2.534,P=0.137)。结论 131I固定剂量法简化治疗步骤,节约治疗费用,是值得提倡的治疗方法。
Abstract:
Objective To compare clinical efficacy of 131I treatment for hyperthyroidism between fixed dose and calculated dose methods. Methods One hundred and forty eight patients with hyperthyroidism were randomly allocated fixed dose and calculated dose groups. Follow up was done 6 months post therapy, serum free triiodothyronine(FT3), free thyroxin(FT4) and thyroid stimulating hormone(TSH) were measured and following clinical outcome was monitored. Results The occurrence of hypothyroidism 6 months after 131I treatment in fixed dose and calculated dose groups was 31.1% and 28.4% respectively. There was no distinct difference between them(χ2=0-742, P=0.528). The cure rate was 93.3% and 85.2% respectively. There was no distinct difference between them(χ2=0.958, P=0.403). A good correlation was between clinical efficacy and thyroid mass(F=13.639, P=0.000). There was no distinct diflerence between the two groups of ages and 24 h radioactive iodine uptake(F=l.374, P=0.241; F:2.534,P=0.137). Conclusion The use of a fixed dose method simplifies the approach to treatment with potential cost savings.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2009-05-27。
通讯作者:曾钦文(E-mail:zqwen72@163.com)
更新日期/Last Update: 1900-01-01