[1]高玉婷,王自正.生长抑素类似物介导靶向显像及治疗的研究现状和进展[J].国际放射医学核医学杂志,2009,33(6):330-334.[doi:10.3760/cma.j.issn.1673-4114.2009.06.003]
 GAO Yu-ting,WANG Zi-zheng.The development of somatostatin analogues mediated tumor targeting and therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(6):330-334.[doi:10.3760/cma.j.issn.1673-4114.2009.06.003]
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生长抑素类似物介导靶向显像及治疗的研究现状和进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第6期
页码:
330-334
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The development of somatostatin analogues mediated tumor targeting and therapy
作者:
高玉婷 王自正
南京医科大学附属南京第一医院核医学科, 南京 210006
Author(s):
GAO Yu-ting WANG Zi-zheng
Department of Nuclear Medicine, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China
关键词:
生长抑素受体肿瘤放射性核素显像放射疗法
Keywords:
SomatostatinreceptorTumorRadionuclide imagingRadiotherapy
DOI:
10.3760/cma.j.issn.1673-4114.2009.06.003
摘要:
放射性核素标记生长抑素类似物对神经内分泌肿瘤进行靶向诊断和靶向治疗已得到临床广泛认可。大多数生长抑素类似物仅对生长抑素受体2具有较高的亲和力,限制了其在临床中的应用。新一代生长抑素类似物如:1,4,7,10-四氮杂环十二烷-N,N’,N",N’"-四乙酸-1-萘丙氨酸-奥曲肽(DOTA-NOC)等,可与更多亚型的生长抑素受体结合且具有更高的亲和力,可由发射不同射线的多种核素标记,已引起广泛重视。该文在介绍常规生长抑素类似物的基础上,着重讨论新的生长抑素类似物、新的螯合剂、新的标记核素及其新的组合,展望生长抑素受体介导肿瘤显像及治疗的前景。
Abstract:
Radionuclide labelled somatostatin analogues have been widely used in the detection of neuro-endocrine tumors. Till now, most of somatostatin analogues only have high affinity to somatostatin receptor 2(SSTR2), further clinical applications was limitted. A new generation of somatostatin analogues such as 1,4,7,10-tetraazacyclodocecane-N,N’,N",N’"-tetaraacetic acid-Nal3-octertide(DOTA-NOC) etc,binding to somatostatin receptors not only SSTR2 but other subtypes has been used mainly in preclinical study. In this review, we discussed these new somatostatin analogues, chelating agent, and their new labelled compounds, these new radionuclide labelled somatostatin analogues may hold great promise for the receptor-mediated tumor imaging and treatments.

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备注/Memo

备注/Memo:
收稿日期:2009-06-02。
基金项目:国家自然科学基金(30700186)
通讯作者:王自正(E-mail:zzwangl36@yahoo.com.cn)
更新日期/Last Update: 1900-01-01