[1]刘键,张现忠,张仕坚,等.99Tcm标记双膦酸盐骨显像剂的研究进展[J].国际放射医学核医学杂志,2009,33(5):296-299.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.013]
　LIU Jian,ZHA NG Xian-zhong,ZHA NG Shi-jian,et al.The new advanced of 99Tcm-labeled bisphosphonates as bone scintigraphy agent[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):296-299.[doi:10.3760/cnla.j.issn.1673-4114.2009.05.013]
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99Tcm标记双膦酸盐骨显像剂的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第5期
页码:
296-299
栏目:
核医学技术和方法
出版日期:
1900-01-01

文章信息/Info

Title:
The new advanced of 99Tcm-labeled bisphosphonates as bone scintigraphy agent
作者:
刘键;  张现忠;  张仕坚;  王学斌
北京师范大学化学系教育部放射性药物重点实验室, 北京 100875
Author(s):
LIU Jian;  ZHA NG Xian-zhong;  ZHA NG Shi-jian;  WANG Xue-bin
Key Laboratory of Radiopharmaceuticals, Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing 100875, China
关键词:
二膦酸盐类; 锝; 同位素标记; 骨显像剂
Keywords:
Disphosphonates; Technetium; Isotope labeling; Bone scintigraphy agent
DOI:
10.3760/cnla.j.issn.1673-4114.2009.05.013
摘要:
双膦酸盐是一类具有很强亲骨性的药物,99Tcm标记的双膦酸盐如99Tcm-亚甲基二膦酸盐(99Tcm-MDP)等被广泛应用于骨显像。近些年来,为了克服99Tcm-MDP的缺点,许多新型的双膦酸配体被设计与合成,以期望获得性能更加优异的骨显像剂。该文对近10年来发展的99Tcm标记双膦酸盐类骨显像剂的结构与性能进行了综述。
Abstract:
Bisphosphonates have a strong affinity for bone tissue and hydroxyapatite.Some of them have been labelled with 99Tcm for bone scintigraphy agent.This article is intended to summarize research and development in some new 99Tcm labeled bisphosphonates as bone scintigraphy agent in recent years.

参考文献/References:

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　BAI Xu-dong,TANG Zhi-gang,WANG Xue-bin.The development of 99Tcm labeled isonitrile complexes[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(5):19.

备注/Memo

备注/Memo:
收稿日期:2009-06-05。
通讯作者:王学斌(E-mail:xbwang@bnu.edu.cn)
更新日期/Last Update: 1900-01-01