[1]张颖,林军.125I粒子治疗对肝癌细胞凋亡及细胞周期的影响[J].国际放射医学核医学杂志,2009,33(4):193-195.[doi:10.3760/cma.j.issn.1673-4114.2009.04.001]
 ZHANG Ying,LIN Jun.Effects of 125I seed brachytherapy on apoptosis and cell cycle distribution in hepatoma carcinoma cells[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):193-195.[doi:10.3760/cma.j.issn.1673-4114.2009.04.001]
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125I粒子治疗对肝癌细胞凋亡及细胞周期的影响(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第4期
页码:
193-195
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Effects of 125I seed brachytherapy on apoptosis and cell cycle distribution in hepatoma carcinoma cells
作者:
张颖 林军
福建医科大学附属第一医院核医学科, 福州, 350005
Author(s):
ZHANG Ying LIN Jun
Department of Nuclear Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
关键词:
肝肿瘤碘放射性同位素近距离放射疗法细胞凋亡细胞周期
Keywords:
Liver neoplasmsIodine radioisotopeBrachytherapyApoptosisCell cycle
DOI:
10.3760/cma.j.issn.1673-4114.2009.04.001
摘要:
125I粒子低剂量率连续照射肝癌细胞,能明显上调细胞Bax表达,降低Bcl-2表达,同时明显诱导细胞凋亡的发生,且细胞周期发生再分布,照射后细胞被阻滞在对辐射相对敏感的G2-M和S期。研究结果表明,125I粒子连续照射能够通过诱导凋亡的途径,明显杀伤肿瘤细胞。
Abstract:
Continuous irradiation of low dose rate 125I seed resulted in an increase in the apoptosis and an increased expression of Bax and a decreased expression of Bcl-2. The cell-cycle arrest of hepatoma carcinoma cells was induced remarkably. The results demonstrated that low dose rate of continuous 125I seed irradiation is effective on inducing the damage-of the tumor cells.

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备注/Memo

备注/Memo:
收稿日期:2009-04-16。
基金项目:福建省教育厅资助项目(项目编号:JB:06255)
通讯作者:林军,E-mail:linjun480311@163.com
更新日期/Last Update: 1900-01-01