[1]王洗,刘强.替莫唑胺联合适形放疗治疗恶性脑胶质瘤的临床观察[J].国际放射医学核医学杂志,2009,33(2):128-128.[doi:10.3760/cma.j.issn.1673-4114.2009.02.020]
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替莫唑胺联合适形放疗治疗恶性脑胶质瘤的临床观察(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第2期
页码:
128-128
栏目:
临床放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
The clinical observation of the treatment for malignant gliomas with temozolomide combined with conformal radiotherapy
作者:
王洗1 刘强2
1. 天津港口医院神经内科, 天津 300456;
2. 中国医学科学院放射医学研究所临床室, 天津 300192
关键词:
脑胶质瘤放射疗法适形替莫唑胺
DOI:
10.3760/cma.j.issn.1673-4114.2009.02.020
摘要:
恶性脑胶质瘤是成年人中常见的原发性脑瘤,占复发脑瘤的35%~45%[1],其标准治疗方案是手术后辅助放疗.三维适形放疗技术较常规放疗有可减少脑组织损伤、提高肿瘤辐射剂量的优势,但总体疗效仍不令人满意,既往放疗中加入治疗脑胶质瘤化疗药物包括卡氮芥、甲基苄肼等,但与单纯放疗相比无显著的生存益处[2].

参考文献/References:

[1] 谷铣之,殷蔚伯,等.肿瘤放射治疗学.北京:北京医科大学中国协和医科大学联合出版社,1997:737-738.
[2] 罗素霞,马保根,陈小兵,等.血清肿瘤标志物联合检测在肺癌诊断中的价值.中华检验医学杂志,2005,28(12):1266.
[3] Brandes AA, Ermani M, Basso U, et al. Temozolomide as a secondline systemic regimen in recurrent high-grade glioma:a phase II study. Ann Oncol, 2001, 12(2):255-257.
[4] Shaw EG, Bourland D, Marshall MG. Cancer of the central nervous system//Khan FM, Potish RA. Treatment planning in radiation oncology. Pennsylvania:Lippincott Williams and Wilkins, 1998:491-544.
[5] van Rijn J, Heimans JJ, van den Berg J, et al. Survival of human glionm cells treated with various combination of temozolomide and X-rays. Int J Radiat Oncol Biol Phys, 2000, 47(3):779-784.
[6] Corsa P, Parisi S, Raguso A, et al. Temozolomide and radiotherapy as first-line treatment of high-grade gliomas. Tumori, 2006, 92(4):299-305.
[7] Stupp R, Mason WP, van den Bent M J, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med, 2005, 352(10):987-996.

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备注/Memo

备注/Memo:
收稿日期:2008-11-12。
通讯作者:刘强(E-mail:lq6688@yahoo.com.cn)
更新日期/Last Update: 1900-01-01