[1]李楠,李培勇.放射性碘间接标记抗体方法的研究进展[J].国际放射医学核医学杂志,2008,32(5):260-263.
 LI Nan,LI Pei-yong.The recent development of the strategy for indirect antibody radiolabel with iodine[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(5):260-263.
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放射性碘间接标记抗体方法的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第5期
页码:
260-263
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The recent development of the strategy for indirect antibody radiolabel with iodine
作者:
李楠 李培勇
200025 上海, 上海交通大学瑞金医院核医学科
Author(s):
LI Nan LI Pei-yong
Department of Nuclear Medicine, Shanghai Ruijing Hospital Affiliated Shanghai Jiaotong University, Shanghai 200025, China
关键词:
同位素标记碘放射性同位素抗体单克隆
Keywords:
Isotope labelIodine radioisotopesAntibodies momeclonal
摘要:
放射性碘标记单克隆抗体已广泛应用于临床疾病的诊治。内化型抗体的应用越来越受到重视,常规运用的碘直接标记法包括Iodogen标记法、氯胺-T标记法等,制备的碘标记单克隆抗体在体内容易脱碘和损伤抗体免疫活性的特性而阻碍了其在体内应用。如何对抗体进行有效的碘标记来减少体内脱碘和抗体免疫活性损伤,对运用碘标记抗体进行肿瘤治疗是十分重要的,研究表明,间接标记法是一种较为恰当的方案。
Abstract:
Radioiodine labeled monoclonal antibodies have been widely used in the diagnosis and treatment of diseases.With the more and more attention which is attached to the application of the internalized McAb.The usual direct labeling methods, including Iodogen and chloramine-T, lead to obvious deiodination and decline of the McAb’s immunological activity which impede their utilization in vivo.There is great importance for the tumor treatment with the radioiodine labeled antibodies to invent a new method in order to avoid the disadvantage described above.It is showed that indirect labeling way is a suitable strategy.In this review, we are introducing the recent advance of this method.

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备注/Memo

备注/Memo:
收稿日期:2008-06-08。
通讯作者:李培勇(E-mail:Peiyili@vip.sina.com)
更新日期/Last Update: 1900-01-01