[1]黄晓菲,曹建平.聚腺苷二磷酸核糖聚合酶抑制剂的作用机制和应用前景[J].国际放射医学核医学杂志,2008,32(2):105-108.
 HUANG Xiao-fei,CAO Jian-ping.The mechanism of action of poly (ADP-ribose) polymerases inhibitors and its application perspective[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(2):105-108.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第2期
页码:
105-108
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The mechanism of action of poly (ADP-ribose) polymerases inhibitors and its application perspective
作者:
黄晓菲 曹建平
215123 苏州, 苏州大学放射医学与公共卫生学院放射生物教研室
Author(s):
HUANG Xiao-fei CAO Jian-ping
Department of Radiation Biology, School of Radiation Medicine and Public Health, Soochow University, Suzhou 215123, China
关键词:
辐射耐受性药物耐受性聚腺苷二磷酸核糖聚合酶抑制剂
Keywords:
RaditoleranceDrug tolerancePoly(ADP-ribose)polymerase inhibitor
摘要:
聚腺苷二磷酸核糖聚合酶家族由众多调控细胞进程的酶组成,其参与人体内多种生理及病理生理过程。近些年,人们对此酶及其抑制剂进行了广泛的研究,其中侧重于聚腺苷二磷酸核糖聚合酶抑制剂在辐射增敏、化学药物增敏、神经保护等方面所发挥的作用。现已有聚腺苷二磷酸核糖聚合酶抑制剂进入临床药物试验,预示其具有良好的应用前景。
Abstract:
Poly (ADP-ribose) polymerases (PARP) constitute a family of enzymes involved in the regulation of many cellular processes. It plays a vital role in many physical and physiopathological processes. In the past ten years scientists have conducted extensive research on PARP and its inhibitors, among which the role of PARP inhibitors in radiosensitization, chemopotentiation and neuroprotection have been placed close attention. There have been several PARP inhibitors entering the clinical trials, which predicts its sound application perspectives.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-07-09。
通讯作者:曹建平(E-mail:jpcao@suda.edu.cn)
更新日期/Last Update: 1900-01-01