[1]杜雪梅,张延军.核素乏氧显像在肿瘤放射治疗中的应用[J].国际放射医学核医学杂志,2008,32(2):96-98.
　DU Xue-mei,ZHANG Yan-jun.Clinical application of nuclear hypoxia imaging on oncology radiation therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(2):96-98.
点击复制

核素乏氧显像在肿瘤放射治疗中的应用(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第2期
页码:
96-98
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Clinical application of nuclear hypoxia imaging on oncology radiation therapy
作者:
杜雪梅;  张延军
116011 大连, 大连医科大学附属第一医院核医学科
Author(s):
DU Xue-mei;  ZHANG Yan-jun
Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
关键词:
细胞低氧; 放射肿瘤学; 乏氧显像
Keywords:
Cell hypoxia; Radiation oncology; Hypoxia imaging
摘要:
核素乏氧显像是一种可以为肿瘤乏氧程度提供定性及定量信息的显像,方法简便、安全、无创伤性。常用的乏氧组织显像剂有硝基咪唑类和非硝基咪唑类,前者进入细胞后,被还原的有效基团(-NO2)在乏氧细胞中不能再氧化而滞留于肿瘤细胞中,后者在乏氧组织中的滞留机制因显像剂的不同而不同。运用核素乏氧显像了解肿瘤组织的乏氧状态,对临床制定合理的放疗方案、评估放疗疗效有重要意义。
Abstract:
Nuclear hypoxia imaging is a convenient and safe method which can provide qualitative and quantitative information of oncology hypoxic degree. The commonly used imaging agent have two categories. Nitroimidazole agent, which effective group (-NO2) reducted in the hypoxia cell can not be reoxidized and be detained in it. Nonitroimidazole agent, which imaging mechanisms are different according to different agents. This technology is useful to formulate reasonable radiotherapy plan and evaluate radiotherapy effect.

参考文献/References:

[1] Lehtiö K, Oikonen V, Nyman S, et al. Quantifying tumor hypoxia with fluorine-18 fluoroerythronitroimidazole([18F]FETNIM)and PET using the turnout to plasma ratio[J]. Eur J Nuel Med Mol Imaging, 2003, 30(1):101-108.
[2] Wiebe LI, Mcewan AJB. Scintigraphic imaging of focal hypoxic tissue:development and clinical applications of 123HAZA[J]. Braz Arch Biol Technol, 2002, 45:69-81.
[3] Melo T, Ballinger JR, Rauth AM. Role of NADPH:cytochrome P450 reductase in the hypoxic accumulation and metabolism of BRU59-21, a technetium-99m-nitroimidazole for imaging tumor hypoxia[J]. Biochem Pharmacol, 2000, 60(5):625-634.
[4] Cook GJ, Houston S, Barrington SF, et al. Technetium-99m-labeled HL91 to identify tumor hypoxia:correlation with fluorine-18-FDG[J]. J Nucl Med, 1998, 39(1):99-103.
[5] Takahashi N, Fujibayashi Y, Yonekura Y, et al. Evaluation of 62Cu labeled diacetyl-bis (N4-methylthiosemicarbazone)as a hypoxic tissue tracer in patients with lung cancer[J]. Ann Nucl Med, 2000, 14(5):323-328.
[6] 徐瑾,张自成.肿瘤乏氧显像与放疗研究进展[J].国外医学:肿瘤学分册,2004,31(5):355-358.
[7] Van de Wiele C, Lahorte C, Oyen W, et al. Nuclear medicine imaging to predict response to radiotherapy:a review[J]. Int J Radiat Oncol Biol Phys, 2003, 55(1):5-15.
[8] Chao KS, Bosch WR, Mutic S, et al, A novel approach to overcome hypoxic tumor resistance:Cu-ATSM-guided intensity-modulated radiation therapy[J]. Int J Radiat Oncol Biol Phys, 2001, 49(4):1171-1182.
[9] 刘保平,闫瑾.用99Tcm-HL91显像预测脑肿瘤放疗敏感性[J].中华核医学杂志,2005,25(5):284-285.
[10] Dehdashti F, Grigsby PW, Mintun MA, et al. Assessing tumor hypoxia in cervical by positron emission tomography with 60Cu-ATSM:ralationship to therapeutic response-a preliminary report[J]. Int J Radiat Oncol Biol Phys, 2003, 55(5):1233-1238.
[11] Suzuki T, Nakamura K, Kawase T, et al. Monitoring of response to radiation therapy for human tumor xenografts using 99mTc-HL91(4,9-diaza-3,3,10,10-tetramethyldodecan-2, 11-dione dioxime)[J]. Ann Nucl Med, 2003, 17(2):131-138.
[12] Kinuya S, Yokoyama K, Konishi, et al. Increased uptake of 99mTc-HL91 in tumor cells exposed to X-ray radiation[J]. Ann Nucl Med, 2000, 14(2):139-141.
[13] 胡旭东,杨国仁,张鹏,等.99mTc-HL-91乏氧显像监测放疗前后肿瘤乏氧状态的动物实验研究[J].现代肿瘤医学,2005,13(3):351-353.

相似文献/References:

[1]司宏伟,徐慧琴,岳峤,等.肿瘤组织乏氧与葡萄糖代谢[J].国际放射医学核医学杂志,2009,33(4):200.[doi:10.3760/cma.j.issn.1673-4114.2009.04.003]
　SI Hong-wei,XU Hui-qin,YUE Qiao,et al.Hypoxia and glycometabolism in cancer tissue[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(2):200.[doi:10.3760/cma.j.issn.1673-4114.2009.04.003]
[2]林伟,邬恒夫,武兆忠,等.99mTc-HL91显像在缺血陛脑血管病中脑乏氧组织的应用研究[J].国际放射医学核医学杂志,2008,32(3):165.
　LIN Wei,WU Heng-fu,WU Zhao-zhong,et al.Preliminary study on detection of brain hypoxic tissue in the patients with ischemic cerebrovascular of brain using 99mTc-HLgl imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(2):165.
[3]郭阳.红细胞生成素及其受体与肿瘤组织乏氧的关系及对治疗的影响[J].国际放射医学核医学杂志,2007,31(5):306.
　GUO Yang.Erythropoietin and erythropoietin receptor: relationship to tumor hypoxia and treatment[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):306.
[4]薛咏,刘生,张弘,等.鼻咽癌乏氧程度与放疗中期肿瘤退缩关系的初步研究[J].国际放射医学核医学杂志,2007,31(4):232.
　XUE Yong,LIU Sheng,ZHANG Hong,et al.The relationship between tumor regression degree and its hypoxia degree in patients with nasopharyngeal carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(2):232.
[5]王亚飞,孟庆勇.放射性核素反义技术在肿瘤治疗中的研究[J].国际放射医学核医学杂志,2006,30(3):142.
　WANG Ya-fei,MENG Qing-yong.Application of the radionuclide antisense technique in the treatment of tumors[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):142.
[6]李小东,张遵城,董华,等.核医学技术在肿瘤治疗中的应用与进展[J].国际放射医学核医学杂志,2006,30(3):163.
　LI Xiao-dong,ZHANG Zun-cheng,DONG Hua,et al.Development and clinical applications of nuclear medicine on oncology therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):163.
[7]刘军叶,郭鹞,郭国祯.乏氧靶向性自杀基因治疗系统增强胰腺癌放疗效果的实验研究[J].国际放射医学核医学杂志,2006,30(3):168.
　LIU Jun-ye,GUO Yao,GUO Guo-zhen.Hypoxia-targeted suicidal gene therapy system enhances antitumor effects of radiotherapy on pancreatic cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):168.
[8]苏新辉,吴华.99mTc-HL91乏氧显像探测肿瘤乏氧状态的研究进展[J].国际放射医学核医学杂志,2006,30(4):220.
　SU Xin-hui,WU Hua.Advances in identifying the hypoxic status of malignant tumors with 99mTc-HL91 scintigraphy[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):220.
[9]顾菲,刘晓秋.肿瘤辐射增敏的分子机制[J].国际放射医学核医学杂志,2006,30(5):298.
　GU Fei,LIU Xiao-qiu.The molecular mechanism of tumor radiosensitizer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):298.
[10]杨天恩.放射肿瘤学发展史概要[J].国际放射医学核医学杂志,1995,19(5):199.

备注/Memo

备注/Memo:
收稿日期:2007-06-15。
通讯作者:杜雪梅(E-mail:dxm57@sina.com)
更新日期/Last Update: 1900-01-01