[1]蔡秋琼,杜明华.131Ⅰ-rituximab治疗B细胞非霍奇金淋巴瘤[J].国际放射医学核医学杂志,2008,32(2):72-74.
 CAI Qiu-qiong,DU Ming-hua.131Ⅰ-rituximab therapy of B cell non-Hodgkin lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(2):72-74.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第2期
页码:
72-74
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
131Ⅰ-rituximab therapy of B cell non-Hodgkin lymphoma
作者:
蔡秋琼 杜明华
210009 南京, 东南大学临床医学院附属中大医院
Author(s):
CAI Qiu-qiong DU Ming-hua
Department of Nulear Medicine, Zhongda Hospital Affiliated to Clinical College of Southeast University, Nanjing 210009, China
关键词:
抗原CD20抗体抗独特性放射免疫疗法淋巴瘤非霍奇金
Keywords:
Antigens CD20Antibodies anticardiolipinRadioimmunotherapyLymphomanon-Hodgkin
摘要:
放射免疫治疗是将单克隆抗体(单抗)耦联放射性核素,在肿瘤局部产生足够的电离辐射生物学效应,达到高效、低毒的治疗效果。非霍奇金淋巴瘤(NHL)是最常见的淋巴系统恶性肿瘤之一,其绝大多数是B细胞来源,细胞分化抗原CD20是放射免疫治疗B细胞NHL的最佳靶点,用131Ⅰ标记rituximab (一种抗CD20单抗)在治疗B细胞NHL的临床研究中显示出良好的效果,但仍存在许多问题,人们正在进一步研究解决此类问题,以取得更好的治疗效果。
Abstract:
Radioimmunotherapy, a kind of internal radiation therapy, can achieve high performance and low toxicity by fewer monoclonal antibodies couple radioactive nuclides, created sufficient ionization biologic effect on tumor. Non-Hodgkin lymphoma (NHL) is the most common hematological malignancy. Most of them are B cell lymphomas. CD20 is the best target of radioimmunotherapy on B cell-NHL. Clinical trials indicate 131Ⅰ-rituximab is effective on B cell-NHL, while many problems are existed. Approaches are under investigation to improve outcomes in patients with B cell-NHL.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-06-28。
基金项目:江苏省重点技术创新项目(7625003030)
通讯作者:杜明华(E-mail:njdmh@yahoo.com.cn)
更新日期/Last Update: 1900-01-01