[1]刘晓飞,张锦明,王洁磊,等.放射性核素标记RGD序列多肽与整合素αvβ3受体显像的研究进展[J].国际放射医学核医学杂志,2008,32(1):12-15.
 LIU Xiao-fei,ZHANG Jin-min,WANG Jie-lei,et al.Study progress of malignant tumor imaging of integrin αvβ3 expression with radioisotope labelled RGD peptides[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(1):12-15.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第1期
页码:
12-15
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Study progress of malignant tumor imaging of integrin αvβ3 expression with radioisotope labelled RGD peptides
作者:
刘晓飞1 张锦明1 王洁磊2 田嘉禾1
1. 100853 北京, 解放军总医院核医学科;
2. 325000 浙江温州, 武警浙江总队温州支队卫生队
Author(s):
LIU Xiao-fei1 ZHANG Jin-min1 WANG Jie-lei2 TIAN Jia-he1
1. Department of Nuclear Medicine, The General Hospital of PLA, Beijing 100853, China;
2. Wenzhou Detachment Medical Team of Chinese People’s Armed Police Forces, Zhejiang Wenzhou 325000, China
关键词:
肽类受体玻连蛋白放射性核素显像精氨酸-甘氨酸-天冬氨酸肽
Keywords:
PeptidesReceptorsvitronectinRadionuclide imagingArginine-glyeine-aspartie acid
分类号:
Q516
摘要:
整合素主要介导细胞与细胞、细胞与细胞外基质(ECM)之间的相互黏附,对细胞的黏附、增殖、分化、转移、凋亡起到重要的调控作用,在肿瘤的侵袭转移中发挥重要作用。成熟血管内皮细胞和绝大多数正常器官系统中,整合素αvβ3受体表达缺乏或几乎不能被探及,但其在新生血管内皮细胞中有强烈表达,精氨酸-甘氨酸-天冬氨酸(RGD)肽是整合素αvβ3受体的特异性识别位点,因此,将放射性核素标记到含有RGD序列的肽类化合物上,用于整合素αvβ3受体显像,对于肿瘤早期和高特异性定位、定量诊断及治疗都具有重要意义。近年来国内外对RGD肽的标记方法和αvβ3受体显像进行了研究。
Abstract:
The malignant tumors must establish a neovasculature to grow, to invade, and to metastasize, in which αvβ3 integrin plays an important role. It is reported that the αvβ3 integrin made their effection mainly by binding triplet peptides RGD sequence in the proteins of the extracellular matrix. Because is reported to there is no or rare αvβ3 integrin in normal cells but more in activated endothelial cells, RGD is the special target point for αvβ3 Integrin. RGD antagonistic peptides radiolabelled by direct or indirect way could be used to display tumor αvβ3 Integrin by nuclear medicine image. It is of significance to locate and quantitate tumor Integrin high special in early diagnosis and therapy. This article reviews the marking method of RGD peptide and study about the image of αvβ3 receptor.

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备注/Memo

备注/Memo:
收稿日期:2007-06-13。
通讯作者:张锦明,E-mail:zhangjm301@yahoo.com.cn
更新日期/Last Update: 1900-01-01