[1]李峰生,陈肖华.RNA干涉治疗脑胶质瘤的研究进展[J].国际放射医学核医学杂志,2007,31(5):300-302.
 LI Feng-sheng,CHEN Xiao-hua.Research progress on treatment of glioma with RNA interference[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(5):300-302.
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RNA干涉治疗脑胶质瘤的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第5期
页码:
300-302
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
Research progress on treatment of glioma with RNA interference
作者:
李峰生 陈肖华
100850 北京, 军事医学科学院放射与辐射医学研究所急性放射病损伤治疗研究室
Author(s):
LI Feng-sheng CHEN Xiao-hua
Department of Acute Radiation Sickness, Beijing Institute of Radiation Medicine, Beijing 100850, China
关键词:
脑胶质瘤细胞增殖细胞凋亡细胞周期辐射耐受性RNA干涉
Keywords:
GliomaCell proliferationCell apoptosisCell cycleRadiosensitvityRNA interference
分类号:
Q506;R730.5
摘要:
RNA干涉(RNAi)是由双链RNA引发序列特异性的转录后基因沉默.RNA干涉(RNAi)技术的出现为胶质瘤基因治疗的研究提供了新的策略.在研究过程中,不断有新的可能用于RNAi治疗脑胶质瘤的靶标基因被发现,其治疗脑胶质瘤作用主要通过抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、导致肿瘤细胞周期阻滞或增加肿瘤细胞化疗敏感性的机制来实现.
Abstract:
RNA interference (RNAi) is a post-transcriptional gene silencing induced by introduction of double-stranded RNA (dsRNA). The emerging of RNAi provided a new method for glioma gene therapy. During the research, many new potential genes are continually finding out. And the glioma-treating mechanism include inhibiting cell proliferation, inducing cell apoptosis, blocking cell eyele and enhancing cell sensitivity of chemical.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-03-16。
基金项目:国家自然科学基金资助项目(30770640)
通讯作者:陈肖华(E-mail:chenxh@nic.bmi.ac.cn)
更新日期/Last Update: 1900-01-01