[1]郑薇,谭建.甲状腺癌的基因治疗[J].国际放射医学核医学杂志,2007,31(4):197-201.
 ZHENG Wei,TAN Jian.Gene therapy of thyroid carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(4):197-201.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第4期
页码:
197-201
栏目:
实验核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Gene therapy of thyroid carcinoma
作者:
郑薇 谭建
300052 天津, 天津医科大学总医院核医学科
Author(s):
ZHENG Wei TAN Jian
Department of Nuclear Medicine, Generd Hospital of Timjin Medical University, Tianjin 300652, China
关键词:
甲状腺肿瘤基因疗法碘放射性同位素
Keywords:
Thyroid neoplasmGene therapyIodine radioisotopes
分类号:
R730.54
摘要:
分化型甲状腺癌通常预后良好,但是对于约30%的低分化甲状腺癌,常规的治疗方法如"手术+131I治疗+甲状腺激素"的效果并不理想。国内外学者都在探索一种新的治疗策略——基因治疗。目前甲状腺癌的基因治疗策略主要有如下方面:(1)导入钠/碘同向转运体(NIS)基因,使本来不吸131I的癌细胞能够吸131I,从而采用放射性131I治疗;(2)增强机体抗肿瘤的免疫反应;(3)导入肿瘤细胞"自杀"基因;(4)抑制肿瘤细胞的生成;(5)抗血管生成基因治疗等。
Abstract:
Normally, differentiated thyroid carcinoma(DTC) is a disease of good prognosis, but about 30% of the tumors are dedifferentiate, which are inaccessible to standard therapeutic procedures such as "operation 131I therapy mid thyroid hormone". Both internal and abroad experts are researching a new therapy of dedifferentiated thyroid carcinoma——gene therapy. Many of them utilize methods of it, but follow different strategies:(1) transduction of the thyroid sodium/iodide transporter gene to make tissues that do not accumulate iodide treatable by 131I therapy;(2) strengthening of the anti-tumor immune response;(3) suicide gene therapy;(4) depression the generation of tumor cells;(5) gene therapy of anti-vascularization.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-03-07。
通讯作者:谭建(E-mail:tanpost@163.com)
更新日期/Last Update: 1900-01-01