[1]常公民,彭瑞云.中子辐射致骨髓损伤及治疗研究进展[J].国际放射医学核医学杂志,2007,31(3):185-188.
　CHANG Gong-min,PENG Rui-yun.Advances on the injury effects and therapy of bone marrow induced by neutron radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(3):185-188.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第3期
页码:
185-188
栏目:
临床放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Advances on the injury effects and therapy of bone marrow induced by neutron radiation
作者:
常公民;  彭瑞云
100850 北京, 军事医学科学院放射与辐射医学研究所实验病理学研究室
Author(s):
CHANG Gong-min;  PENG Rui-yun
Department of Experimental Pathology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
关键词:
中子; 骨髓; 辐射损伤; 综合疗法; 细胞因子类
Keywords:
Neutron; Bone marrow; Radiation injury; Combined modality therapy; Cytokines
分类号:
R818.71;R818.05
摘要:
中子相对生物效应较高,能对机体产生十分严重的损伤.骨髓是中子辐射高度敏感的器官,低剂量中子照射即可对骨髓造成严重的辐射损伤,产生骨髓型急性放射病,出现外周血血象改变、造血细胞和骨髓基质细胞损伤等一系列改变.中子辐射致骨髓损伤治疗的难度大,以综合对症治疗为基础,细胞因子的适时应用及对极重度中子骨髓型放射病则实施造血干细胞移植.
Abstract:
The relative biological effect of neutron is high. Therefore, neutron radiation injures body quite seriously. Bone marrow is the most sensitive organ to neutron radiation. Low-dose neutron can injure bone marrow badly and lead to bone marrow form acute radiation sickness. There are a series of lesions in heraatopoiesis system, such as peripheral blood hemogram change, hematopoietic cell damage and bone marrow stromal cell injury. It is very difficult to cure neutron-induced damage of bone marrow. The primarily curable method is comprehensive symptomatic treatments. Cytokines are used at the right moment. Hematopoietic stem cell transplant is enforced to cure the very serious bone marrow form acute radiation sickness.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-02-05。
基金项目:全军"十一五"医药卫生专项基金项目(06Z064)
通讯作者:彭瑞云,E-mail:Pengry@nic.brai.ac.cn
更新日期/Last Update: 1900-01-01